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The aim of this book is to improve our understanding of creative knowledge environments. The various chapters analyse creative and innovate activities as carried out by individuals, groups and organisations. The book’s focus is on identifying and understanding the factors relating to the working environment that are conducive to human creativity and innovation. The editing of the book has been a c
Nutritional epidemiology is an inherently complex and multifaceted research area. Dietary intake is a complex exposure and is challenging to describe and assess, and links between diet, health, and disease are difficult to ascertain. Consequently, adequate reporting is necessary to facilitate comprehension, interpretation, and generalizability of results and conclusions. The STrengthening the Repo
Inflammation is a vital response and necessary for maintaining homeostasis. Inflammation protects against tissue damage and pathogens-but is also one of the main driving forces of the atherosclerotic plaque progression. How and why the inflammatory response is initiated in the atherosclerotic disease is not fully known, but evidence suggests modified lipids as potential antigens activating the imm
BACKGROUND AND AIMS: The severity of the atherosclerotic burden is hardly quantifiable in subjects at high cardiovascular (CV) risk under intensive pharmacological therapy. Several molecules have been proposed as circulating biomarkers of atherosclerosis, but none has emerged as clinically meaningful.METHODS: Circulating proteins involved in inflammation, plaque remodeling, smooth muscle cell migr
Task 3.1 in Work Package (WP) 3 of the CULTIVATE project aims to investigate costs, investments, challenges, drivers, and success factors to establish and maintain urban and peri-urban food sharing initiatives (FSIs). This investigation builds on the conceptual framework, which has been developed from a systematic literature review on the topic of food sharing and enriched with topics from several
Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual
Since 2009, the Swedish government has allo-cated a part of its direct funding to the Swed-ish universities based on a bibliometric indica-tor, which stems from the number of publica-tions and citations found in the Web of Science bibliographic database. This paper discusses the creation and detailed structure of the new indicator, which has met criticism from both researchers and the Swedish Rese
Looking ahead, the quest for environmental sustainability may turn out to be the most important political challenge of the twenty-first century. Though consensus is growing about some of the policy objectives like climate stability, political attitudes to these issues remain highly contested. Political parties seem to differ on both ontological assessments (how severe are the problems) and remedia
Aims Alternative transcription and splicing of the allograft inflammatory factor-1 (AIF-1) gene results in the expression of two different proteins: AIF-1 and interferon responsive transcript-1 (IRT-1). Here we explore the impact of AIF-1 and IRT-1 on vascular smooth muscle cell (VSMC) activation and neointima formation, the mechanisms underlying their alternative splicing, and associations of AIF
A wide range of methods has been proposed for ensuring central fixation in divided visual field studies of cerebral asymmetry. We present some of the problems associated with ensuring central fixation and argue that objectively monitoring fixation location with an eye-tracking device can provide the only accurate and, therefore, acceptable technique. However, the mere use of this equipment does no
We present a method for human brain fixation based on simultaneous perfusion of 4% paraformaldehyde through carotids after a flush with saline. The left carotid cannula is used to perfuse the body with 10% formalin, to allow further use of the body for anatomical research or teaching. The aim of our method is to develop a vascular fixation protocol for the human brain, by adapting protocols that a
Digital phantoms are virtual representations of the human body used in medical research to test equipment, train medical professionals and develop or validate algorithms. These models can be created from ‘real-world’ clinical data or from ‘synthetic data’. Phantoms derived from clinical data often serves as ‘ground truth’ reference values anchored in empirical observations. However, there is growi
Purpose: Young people transitioning from out-of-home care are a vulnerable group. This article reports two studies aiming to increase understanding of how to develop interventions for this group and focuses on preliminary intervention fit from the youth and social worker perspective. Methods: We conducted two small-scale studies. Social workers (Study I, n = 2; Study II, n = 9), and youth (Study I
Al-Hoorie, Hiver, and In'nami (2024) offer compelling arguments for why L2 motivational self-system research is currently in a state of validation crisis. Seeking a constructive resolution to the crisis, in this response we argue that two fundamental conditions are needed for the field to emerge stronger: psychological readiness and methodological maturity. For psychological readiness, we call for
In the study of motor systems it is often necessary to track the movements of an experimental animal in great detail to allow for interpretation of recorded brain signals corresponding to different control signals. This task becomes increasingly difficult when analyzing complex compound movements in freely moving animals. One example of a complex motor behavior that can be studied in rodents is th
Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-c
A general question for linkage disequilibrium-based association studies is how power to detect an association is compromised when tag SNPs are chosen from data in one population sample and then deployed in another sample. Specifically, it is important to know how well tags picked from the HapMap DNA samples capture the variation in other samples. To address this, we collected dense data uniformly
