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Downstream regulatory element antagonist modulator (DREAM)/potassium channel interacting protein (KChIP3) is a multifunctional protein of the neuronal calcium sensor subfamily of Ca2+-binding proteins with specific roles in different cell compartments. In the nucleus, DREAM acts as a Ca2+-dependent transcriptional repressor, and outside the nucleus DREAM interacts with Kv4 potassium channels, regu
The marine environment harbors a large proportion of the total biodiversity on this planet, including the majority of the earths’ different phyla and classes. Studying the genomes of marine organisms can bring interesting insights into genome evolution. Today, almost all marine organismal groups are understudied with respect to their genomes. One potential reason is that extraction of high-quality
Amyloid fibrils of α-synuclein (α-syn) are a component of Lewy bodies, the characteristic hallmark of Parkinson's disease. Amyloid fibrils arise through primary nucleation from monomers, which in the case of α-syn is often heterogeneous, followed by the growth of the nuclei by monomer addition. Secondary nucleation corresponds to the formation of new fibrils facilitated by pre-existing fibrils. Wh
Hushållen står för cirka 26 % av den årliga energianvändningen i EU. Som följd av EU:s direktiv om energiprestanda i byggnader har det genomförts internationella initiativ i Europa för att hjälpa länder att definiera och inkludera riktlinjer i sina egna byggregler, till exempel för att etablera konceptet nollenergibyggnader. Detta koncept inkluderar passiv-teknik for energibesparande byggande, eneHouseholds are responsible for approximately 26 % of the annual energy use in the EU. Following the EU-directives regarding energy performance in buildings, international initiatives have been taken in Europe to help countries to define and include guidelines in their own building codes, for example, to establish the concept of zero energy buildings, ZEBs. This concept includes passive building en
Meetings are common in contemporary working life, but they are often overlooked in academic studies and sometimes defined as empty or boring by employees. Yet, the meeting society isbeing reproduced again and again. There seem to be hidden ways to incorporate meetings into today’s working life without arousing critique about pointless activities and deviations from what should really be done. One
The aim of this article is to provide an evolutionarily grounded explanation of central aspects of the structure of language. It begins with an account of the evolution of human causal reasoning. A comparison between humans and non-human primates suggests that human causal cognition is based on reasoning about the underlying forces that are involved in events, while other primates hardly understan
Thrombospondin 4 (TSP-4) expression is induced in the heart and vasculature under pathological conditions, including myocardial infarction, myocardial pressure overload, and hypertension. TSP-4 is linked to remodelling processes, where it may affect extracellular matrix protein organization. In previous work, we studied the role of TSP-4 in small arteries during hypertension using Ang II-treated T
Human intrahepatic lymphocytes are enriched in CD1d-unrestricted T cells coexpressing NKR. Although the origin of this population remains controversial, it is possible to speculate that the hepatic microenvironment, namely epithelial cells or the cytokine milieu, may play a role in its shaping. IL-15 is constitutively expressed in the liver and has a key role in activation and survival of innate a
To determine whether the Joint European Societies guidelines on cardiovascular prevention are being followed in everyday clinical practice of secondary prevention and to describe the lifestyle, risk factor and therapeutic management of coronary patients across Europe.
The lifetimes of low-lying excited states below the 8+ seniority isomer were directly measured using fast timing detectors in the neutron-deficient isotopes 98,100Cd. This experiment was conducted with the DEcay SPECtroscopy (DESPEC) setup at GSI, where the ions of interest were produced via a fragmentation reaction and identified using the FRagment Separator (FRS) before being implanted in the AI
Model-based design is an emerging tool for dealing with the uncertain dynamic loads entering wastewater treatment plants (WWTPs). But our understanding about the load-driving population-dynamics is limited. Therefore, we studied if mobility data (mobile telecommunications data) could be used to reduce uncertainties during design. Mobility data from Uppsala, Sweden between 2019–2022 clearly quantif
There has been little, or no, direct testing of theories of gas sorption within particular pores situated amidst a highly inter-connected pore network. The concept of thermodynamically independent pores within networks has also been challenged. In this work, a novel integrated nitrogen sorption and mercury porosimetry technique has been used to deconvolve the condensation and evaporation processes
OBJECTIVES: Early onset ataxia (EOA) concerns a heterogeneous disease group, often presenting with other comorbid phenotypes such as myoclonus and epilepsy. Due to genetic and phenotypic heterogeneity, it can be difficult to identify the underlying gene defect from the clinical symptoms. The pathological mechanisms underlying comorbid EOA phenotypes remain largely unknown. The aim of this study is
It is unclear if the results of randomised controlled trials (RCTs) of behaviour therapy (BT) for Tourette syndrome (TS) and chronic tic disorder (CTD) can be generalised to naturalistic clinical settings and are durable long-term. In this naturalistic study, 74 young people with TS/CTD received BT at a specialist clinic. Data were collected at baseline, post-treatment, and at 3-, 6-, and 12-month
Background: The causes of obsessive-compulsive disorder (OCD) remain unknown. Gene-searching efforts are well underway, but the identification of environmental risk factors is at least as important and should be a priority because some of them may be amenable to prevention or early intervention strategies. Genetically informative studies, particularly those employing the discordant monozygotic (MZ
This release brings together some of Ponce’s finest guitar works, carefully selected and sensitively performed by Bertrand Chavarría-Aldrete. The album opens with a Preludio written not long after Ponce arrived in Paris, characterised by modal and whole tone inflections that lend the piece an impressionistic quality. The release also includes the later set of Seis preludios cortos (‘Six short prel
Urban experiments, living labs and testbeds have emerged as influential approaches to governing cities around the world. Experimental governance allows stakeholders to trial possible futures and to embrace creativity and innovation in the pursuit of sustainability goals. Experiments are often conducted through triple helix partnerships that favour informal and distributed actions. This is a signif
Attosecond transient absorption spectroscopy (ATAS) allows for the study of electron dynamics in atoms and molecules with attosecond time resolution. Previous works reported in the literature have made use of ATAS to image and control such dynamics in the single-channel ionization continuum of helium; in particular, in the vicinity of the doubly excited autoionizing states lying between the N=1and
