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Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemi
Biomolecular motors have inspired the design and construction of artificial nanoscale motors and machines based on nucleic acids, small molecules, and inorganic nanostructures. However, the high degree of sophistication and efficiency of biomolecular motors, as well as their specific biological function, derives from the complexity afforded by protein building blocks. Here, we discuss a novel bott
The androgen receptor is a key transcription factor contributing to the development of all stages of prostate cancer (PCa). In addition, other transcription factors have been associated with poor prognosis in PCa, amongst which c-Myc (MYC) is a well-established oncogene in many other cancers. We have previously reported that the AR promotes glycolysis and anabolic metabolism; many of these metabol
Studies of circular DNA confined to nanofluidic channels are relevant both from a fundamental polymer-physics perspective and due to the importance of circular DNA molecules in vivo. We here observe the unfolding of confined DNA from the circular to linear configuration as a light-induced double-strand break occurs, characterize the dynamics, and compare the equilibrium conformational statistics o
Från titeln att bedöma -Livets Algoritm - kan man tänka sig att Fernando Flores' bok är en strikt vetenskaplig sådan. Detta första intryck förstärkes ytterligare när man läser underrubriken: "Moderna teorier om biologins metod och väsen." Men trots att boken faktiskt bygger på vetenskapliga grunder, är det huvudsakligen fråga om ett filo-sofiskt verk. Och när vi säger "huvudsakligen", tänker vi på
Popular Abstract in Swedish The Third Gospel for the First Time beskriver en förstagångsupplevelse av Lukasevangeliet, en uppläsning inför adressaten Teofilus vänner, vid ett tillfälle då evangeliet var nyskrivet. Den förutsätter att någon av Teofilus vänner kände till antika biografier och uppfattade Lukasevangeliet som en sådan. Dessutom hade han fått en grundläggande undervisning om den kristnaIf Luke’s first audience understood the Gospel as a biography, what would their experience of the text have been? This book invites the reader to accompany the first readers or hearers of Luke’s Gospel and to experience the narrative about the life of Jesus alongside them. It utilises Wolfgang Iser’s theory about reading and readers and focuses on gaps and vacancies in the text. The most important
In this paper the question “Why software vendors focus on roles when they aim at developing the future enterprise resource planning (ERP) systems?” is discussed. At the moment there is increasing interest in developing ERP systems that support a person's different working roles in the organisation, which could be described as role-based ERPs. It could be asked whether this is a reaction to the wel
Sorption may affect the bioavailability and biodegradation of pesticides in soils. The aim of this study was to test the effect of surface sorption on microbial utilization of the herbicide glyphosate as a source of phosphorus, nitrogen, or carbon. We added goethite to a humus soil to manipulate the soil's glyphosate sorption capacity. The addition of glyphosate generally either decreased microbia
High-spin states in the proton-rich nucleus V-45 have been identified for the first time. A comprehensive gamma-ray decay scheme has been established following an experiment performed at the Vivitron accelerator at IReS Strasbourg by using the Euroball gamma-ray detector array coupled to the Neutron Wall and Euclides detector arrays. The natural (negative-) parity scheme is identified up to the f(
Using the LiDAR-derived Swedish national height model we have identified previously undescribed shallow streamlined glacial bedforms, small-scale drumlins, on the Närke plain in south-central Sweden. These drumlins could only be detected with high-resolution LiDAR, due to both their subtle size and forest cover. In this area the ice margin receded in a subaqueous environment with a proglacial wate
A large literature emphasizes that elite capture of political institutions hampered the spread of mass schooling in the nineteenth and twentieth century. We collect new data on investments in elementary education and the distribution of voting rights for more than 2,000 local governments in nineteenth‐century Sweden and document that educational expenditure was higher where the distribution of pol
Maternally inherited parasites are known to impose a wide variety of reproductive manipulations upon their host. These often produce strong selection on the host to suppress the parasite, resulting in a reduction in the frequency of the parasite. However, in the butterfly Hypolimnas bolina, infected with a Wolbachia bacterium, field data demonstrate that suppression of the male-killing phenotype d
