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Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m

Barnreumatologiskt forskningscentrum

Att insjukna i en reumatisk ledsjukdom innebär betydande förändringar i livet, särskilt när det sker under barndomen eller ungdomen. Vår forskning omfattar flera reumatiska och inflammatoriska tillstånd, med särskilt fokus på juvenil idiopatisk artrit (JIA), men även andra sjukdomar som Kawasakis sjukdom och MIS-C (hyperinflammation efter COVID-19-infektion). Vi bedriver både klinisk- och laboratoBeing diagnosed with a rheumatic disease entails significant life changes, especially when it occurs during childhood or adolescence. Our research encompasses several rheumatic and inflammatory conditions, with a particular focus on juvenile idiopathic arthritis (JIA), but also other diseases such as Kawasaki's disease and MIS-C (hyperinflammation following COVID-19 infection). We conduct both cli

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Background The business environment is constantly changing, and the way companies do business is continuously changing, which is highly apparent in the automotive industry. Adaption is a fact for firms who want to stay in the game, but what will give a company a competitive advantage in this mess of constant changes? The above-mentioned are pointing towards a new era; the age of the customer. In t

Infektionsmedicin

Flera forskningsprojekt vid vår avdelning är inriktade på att bättre förstå mekanismer som ligger bakom utvecklingen av svåra infektionssjukdomar, fr.a. orsakade av bakterier men också av virus och svampar. Utgångspunkten för arbetet har ofta varit upptäckten av bakteriella ytproteiner och enzymer som på olika sätt interagerar med människans försvarssystem (medfödd och förvärvad immunitet och blodSeveral research projects at our Division are focused on molecular and cellular mechanisms that contribute to the development of severe infections caused preferentially by bacteria, but also by viruses and fungi. The starting point for this work has often been the discovery of bacterial surface proteins and enzymes that interact with human defenses (innate and acquired immunity and blood coagulati