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Din sökning på "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" gav 194545 sökträffar

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By using an integrated dynamic model we are able to reconstruct the supply and gold price of the past (1920-2010) and this is used to predict the future supply of gold to the market and to make a forecast of the goldprice 2010-2100. The model was validated against field data for the period 1920-2010 and it performs well. The model GOLD is implemented in the STELLA® software and the model described

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This thesis is concerned with theoretical studies of aqueous solutions and biomolecular systems. Part of the present work is to understand equilibrium solvent and solute properties, while the other part is to study processes that occur in these solutions. Three points were focused: (a) the study of structure and dynamics of 1M aqueous NaCl electrolyte solution at a molecular level, which revealed

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An in-house written software package was used to generate templates of QRS complexes and T waves using self-similarity techniques, and leave a residual signal representing only atrial activity. The templating performance differences between individual ECG leads were tested. The mean number of templates in each of the 3 ECG leads was 8±4, 2±1, 7±5 for the QRS complexes, and 11±5, 11±8, 10±5 for the

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A polymorphism consisting of a deletion near the 5' splice site of exon 18 on the alpha2-macroglobulin (A2M) gene (A2M-2) has been suggested to be associated with Alzheimer's disease (AD) in family-based studies. We studied the A2M-2 allele together with the ApoE alleles in a large series on patients with AD (n = 449) and age-matched controls (n = 349). Neuropathologically confirmed diagnoses were

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BACKGROUND AND OBJECTIVES: During the past 10 years several DNA-typing methods have been developed to complement routine serological typing for determination of polymorphisms in the ABO, RH, KEL, JK and FY blood group genes. However, the molecular basis of blood groups can differ widely between ethnic groups. The purpose of this study was to evaluate selected DNA-based methods for phenotype predic

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BACKGROUND AND OBJECTIVES: The treatment of acquired aplastic anemia (AA) is based on allogeneic bone marrow transplantation (BMT) and immunosuppressive therapy. The aim of this study was to assess the outcome of children and adults with AA treated in the last decade, and to determine whether results have improved in two sequential time periods,1991-1996 and 1997-2002. DESIGN AND METHODS: Two-thou

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In order to model the individual electron transfer steps from the manganese cluster to the photooxidized sensitizer P680+ in Photosystem II (PS II) in green plants, the supramolecular complex 4 has been synthesized. In this complex, a ruthenium(II) tris-bipyridine type photosensitizer has been linked to a manganese(II) dimer via a substituted l-tyrosine, which bridges the manganese ions. The trinu

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In soft tissue sarcoma, the prognostic importance of DNA ploidy status is limited. One possible explanation may be technical; small nondiploid stemlines will he diluted in relation to the presence of normal diploid cells and may not be detected by flow cytometry (FCM). We assessed DNA ploidy status in 93 tumors with both FCM and image cytometry (ICM). ICM may permit the exclusion of nonrelevant ce

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In this article I examine the development of the idea of marriage as a personal union whose foundation is the relation between the spouses. The theories which developed within the Church from the eleventh century and onwards put the emphasis on the personal side of marriage; the sacrament of marriage was founded on the union between the spouses and not on family interest. From the middle of the tw

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Popular Abstract in Swedish Denna avhandling utgöres av två separata rapporter, där studieobjektet för den första är en vektorvärd Sturm-Liouville ekvation på formen -(PU')'+QU=zU, xin[0,b), med P^{-1},W,Q hermiteska med lokalt integrerbara matriselement; och under vissa ytterligare villkor på P^{-1} och W. Under dessa förutsättningar härleds några huvudresultat beträf- fande asymptotiken, då z igThis discourse is constituted by two separate reprots, where the first one offers an elementary deduction of the leading order term asymptotics for the Titchmarsh-Weyl M-function corresponding to a vector-valued Sturm-Liouville equation of the form -(PU')'+QU=zu, xin[0,b), with P^{-1},W,Q being hermitean with locally integrable entries; and under some additional conditions on P^{-1} and W. In the

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A study of the ambitions of the managers at AB Robertsfors Bruk and their impact on courses of action in the development of wage policy and social arrangements in the community of Robertsfors during the period 1925-35.This study deals with employer actions during a period of both internal and external change to the organization. The main focus is in the areas of wage policy and social arrangements

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Antibody-based microarrays is a rapidly evolving technology that has gone from the first proof-of-concept studies to more demanding proteome profiling applications, during the last years. Miniaturized microarrays can be printed with large number of antibodies harbouring predetermined specificities, capable of targeting high- as well as low-abundant analytes in complex, nonfractionated proteomes. C

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Objectives In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of lepti

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BACKGROUND: Genetic variants in KLK2 and KLK3 have been associated with increased serum concentrations of their encoded proteins, human kallikrein-related peptidase 2 (hK2) and prostate-specific antigen (PSA), and with prostate cancer in older men. Low PSA concentrations in seminal plasma (SP) have been associated with low sperm motility. To evaluate whether KLK2 and KLK3 genetic variants affect p