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Insulin stimulates fusion, but not tethering, of GLUT4 vesicles in skeletal muscle of HA-GLUT4-GFP transgenic mice. Am J Physiol Endocrinol Metab 302: E950-E960, 2012. First published January 31, 2012; doi:10.1152/ajpendo.00466.2011.-Insulin regulates glucose uptake into fat and muscle by modulating the subcellular distribution of GLUT4 between the cell surface and intracellular compartments. Howe
All species of Hieracium sectt. Hieracium, Vulgata (incl. Bifida) and Oreadea originally described from the Nordic countries, but reported in recent accounts as occuring in the British Isles, have been scrutinised based on specimens and published descriptions. Out of 29 species stated as occurring in Britain and native to Fennoscandia, only four are confirmed (H. caesiomurorum, H. oistophyllum, H.
Background: Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. The transcripti
Background Rye products have been demonstrated to lower the acute insulin demand, induce a low and prolonged blood glucose response (high Glycemic Profile, GP) and reduce subclinical inflammation. These products may therefore contribute to a lowered risk of obesity, type 2 diabetes and cardio vascular disease. The objective of the present paper was to evaluate the mechanism for a reduced postprand
Human activities, especially increased nutrient loads that set in motion a cascading chain of events related to eutrophication, accelerate development of hypoxia (lower oxygen concentration) in many areas of the world's coastal ocean. Climate changes and extreme weather events may modify hypoxia. Organismal and fisheries effects are at the heart of the coastal hypoxia issue, but more subtle regime
Abstract in UndeterminedThis paper analyzes and evaluates the 2007 majority opinion of the German National Ethics Council which seeks to establish new information (as to the inferior quality of legally procurable human embryonic stem cells) as a sufficient reason for a relaxation of the 2002 Stem Cell Law. A micro-level analysis of the opinion’s central section is conducted and evaluated vis à vis
Computer vision applications are very useful to study animal movements, but due to their intrinsic complexity they are challenging to design, implement, and use properly. We here describe a calibration procedure for a laboratory stereo vision system for tracking zooplankton in three dimensions (3D). We demonstrate the crucial importance of using a correct calibration for proper interpretation of a
In the study of insect neuroanatomy, three-dimensional (3D) reconstructions of neurons and neuropils have become a standard technique. As images have to be obtained from whole-mount brain preparations, pigmentation on the brain surface poses a serious challenge to imaging. In insects, this is a major problematic in the first visual neuropil of the optic lobe, the lamina, which is obstructed by the
Recent reports have demonstrated that hypoxia is widespread in the coastal zone of the Baltic Sea. Here we evaluate the long-term trends of dissolved oxygen in bottom waters and of the drivers of coastal hypoxia. Eleven of the 33 sites evaluated had increasing trends of bottom water dissolved oxygen, but only the Stockholm Archipelago presents a consistent positive increasing trend in time. The va
Epigenetics may play a role in the pathophysiology of type 2 diabetes (T2D), and increased DNA methylation of the metabolic master regulator peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) has been reported in muscle and pancreatic islets from T2D patients and in muscle from individuals at risk of T2D. This study aimed to investigate DNA promoter methylation and gen
The objective of this paper is to provide a general account of value relations. But it takes its departure is a special type of value relation, parity. The notion of parity is due to Ruth Chang. According to her, two items may be evaluatively comparable even when neither is better than, worse than, or equally good as the other. There is a fourth kind of comparability: being on a par. Recently, Jos
Lake Vattern, Sweden, is within a graben that formed through rifting along the boundary between two Precambrian terrains. Geophysical mapping and geological coring show that substantial tectonic movements along the Lake Vattern graben occurred at the very onset of the Holocene. This is evident from deformation structures in the soft sediment accumulated on the lake floor. Our interpretation of the
The principle of extended producer responsibility (EPR) has been a policy paradigm behind the development of waste policies in the European Union including the End-of-Life Vehicle (ELV) Directive (2000/53/EC). This study compares and explains the environmental effectiveness of the ELV programmes in the United Kingdom and in Sweden between 1990 and 2005, using a framework that integrates the Dutch
OBJECTIVE- We studied differences between patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes, and classical type 1 diabetes diagnosed after age 35 years. RESEARCH DESIGN AND METHODS- Polymorphisms in HLA-DQB1, INS, PTPN22, and CTLA4 were genotyped in patients with LADA (n = 213), type 1 diabetes diagnosed at >35 years of age (T1D(>35y); n = 257) or <20 years of age (T1D(<20
We quantified the utilization of terrestrial organic matter (OM) in the food web of a humic lake by analyzing the metabolism and the consumers' stable isotopic (C, H, N) composition in benthic and pelagic habitats. Terrestrial OM inputs (3 g C m(-2) d(-1)) to the lake greatly exceeded autochthonous OM production (3 mg C m(-2) d(-1)) in the lake. Heterotrophic bacterial growth (19 mg C m(-2) d(-1))
Background: Soils contain the largest stock of organic carbon (C) in terrestrial ecosystems and changes in soil C stocks may significantly affect atmospheric CO2. A significant part of soil C is present in cultivated soils that occupy about 35 % of the global land surface. Agricultural intensification has led to practices that may decrease soil organic carbon (SOC), and agricultural management has
What determines the seasonal and interannual variation of growth rates in trees in a tropical forest? We explore this question with a novel four-year high-temporal-resolution data set of carbon allocation from two forest plots in the Bolivian Amazon. The forests show strong seasonal variation in tree wood growth rates, which are largely explained by shifts in carbon allocation, and not by shifts i
ABSTRACT Objective: The aim was to explore any change in parents' time use together with their children, changes in their perceived occupational value, and its relationship to children's body mass index (BMI) over the course of a one-year occupation-focused family intervention. Method: The study sample consisted of participants in one arm of a randomized controlled trial, involving mothers and fat
This article analyses current trends in the use of anonymity services among younger Swedes (15-25) and focuses on individuals engaging in illegal file sharing in order to better understand the rationale behind both file sharing as well as online anonymity, especially in relation to enforcement of copyright. By comparing the findings of a survey conducted on three different occasions (early 2009, l
We investigated the efficacy of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes for 4 years in clinical practice.
