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Approximately half of all cancer patients present with cachexia, a condition in which disease-associated metabolic changes lead to a severe loss of skeletal muscle mass. Working toward an integrated and mechanistic view of cancer cachexia, we investigated the hypothesis that cancer promotes mitochondrial uncoupling in skeletal muscle. We subjected mice to in vivo phosphorous-31 nuclear magnetic re
BACKGROUND: In patients with sinus rhythm and normal atrioventricular conduction, pacing only the left ventricle with appropriate atrioventricular delays can result in superior left ventricular and right ventricular function compared with standard biventricular (BiV) pacing.OBJECTIVE: To evaluate a novel adaptive cardiac resynchronization therapy ((aCRT) algorithm for CRT pacing that provides auto
Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic mutations in BRCA1 and/or BRCA2 (BRCA1/BRCA2) also confer selective sensitivity to PARP inhibitors. Thus, assays to detect BRCA1/BRCA2-deficient tumors have been sought. Recently,
This master thesis has shown multiple uses of the Anoto dot pattern and Anoto pen for different applications. One application is the calibration of the robot tool and work object. Another is the use of an Anoto pen and paper as replacement of the ABB Flexpendant to create a lightweight and intuitive control device to control an industrial robot, experimentally demonstrated for the IRB140 robot arm
The railway makes an extensive barrier in the landscape. To lower the impact of this barrier, and to allow people to easily pass it, level crossings are implemented. A level crossing is an intersection in the same plane between railway and road. Here traffic of all sorts meet with railway vehicles, which is why level crossings are one of the most distinct points of conflict in the entire railway s
Insects have been recommended by the FAO as a sustainable food alternative to meat. Despite their nutritional quality and sustainability, most Western countries still see insects as belonging far away from the dinner table. Although still a niche market, Denmark has been at the forefront of innovation and adoption of edible insects. I used integral theory to map out the structural, cultural and pe
In epidemiological and twin populations, prior interview studies have identified an externalizing spectrum of disorders. Could this be detected utilizing objective registry data? In 20,603 twin pairs from the Swedish Twin Registry, we obtained information from national medical, criminal and pharmacy records on drug abuse (DA), criminal behavior (CB) and alcohol use disorders (AUD). Multivariate tw
Measurement of haemoglobin (Hb) adducts from acrylamide (AA) and its metabolite glycidamide (GA) is a possibility to improve the exposure assessment in epidemiological studies of AA intake from food. This study aims to clarify the reliability of Hb-adduct measurement from individual single samples for exposure assessment of dietary AA intake. The intra-individual variations of AA- and GA-adduct le
Cohorts comprising fishermen's families on the east coast of Sweden have been found to have a high consumption of contaminated fish as well as high body burdens of persistent organochlorine pollutants (POPs). Their west coast correspondents are socio-economically similar, but with considerably lower POP exposure since the fish caught on the west coast is far less contaminated. The rationale for th
Background: In a screening study for silent atrial fibrillation (AF), which is a frequent source of cardiac emboli with ischemic stroke, the proportion of non-participants was considerable and their clinical profile differed from the participants' profile. We intended to geo-map the target population and non-participation in an attempt to understand factors related to screening uptake and, thereby
Context: MicroRNAs (miRNA) are noncoding RNAs that post- transcriptionally regulate gene expression. Their altered expression and function have been observed in most urologic cancers. MiRNAs represent potential disease biomarkers and novel therapeutic targets. Objective: To review and evaluate the evidence implicating miRNAs in the pathogenesis of prostate cancer (PCa), bladder cancer (BCa), and r
This study investigates the sensitivity of wastewater treatment plant (WWTP) model performance to the selection of one-dimensional secondary settling tanks (1-D SST) models with first-order and second-order mathematical structures. We performed a global sensitivity analysis (GSA) on the benchmark simulation model No. 2 with the input uncertainty associated to the biokinetic parameters in the activ
Myeloid leukemia of Down syndrome has a better prognosis than sporadic pediatric acute myeloid leukemia. Most cases of myeloid leukemia of Down syndrome are characterized by additional cytogenetic changes besides the constitutional trisomy 21, but their potential prognostic impact is not known. We, therefore, conducted an international retrospective study of clinical characteristics, cytogenetics,
Coprolites (fossilized faeces) are common, yet previously unreported, elements in the Campanian (Upper Cretaceous) shallow-marine strata of Asen, southern Sweden. They are associated with a diverse vertebrate fauna and comprise at least seven different morphotypes that suggest a variety of source animals. Their faecal origin is corroborated by several lines of evidence, including chemical composit
In higher plants, thylakoid membrane protein complexes show lateral heterogeneity in their distribution: photosystem (PS) II complexes are mostly located in grana stacks, whereas PSI and adenosine triphosphate (ATP) synthase are mostly found in the stroma-exposed thylakoids. However, recent research has revealed strong dynamics in distribution of photosystems and their light harvesting antenna alo
Invasive species can displace natives, and thus identifying the traits that make aliens successful is crucial for predicting and preventing biodiversity loss. Pathogens may play an important role in the invasive process, facilitating colonization of their hosts in new continents and islands. According to the Novel Weapon Hypothesis, colonizers may out-compete local native species by bringing with
BACKGROUND AND PURPOSE: The European Cooperative Acute Stroke Study (ECASS) III trial and Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR) data were published in 2008. Riks-Stroke, the Swedish Stroke Register, was used to explore how thrombolysis in the 3- to 4.5-hour window has been spread in different hospitals and patient groups and what effec
Vid ingående av avtal aktualiseras alltid AvtL, samt AVLK om det rör ett konsumentförhållande. När lagarna stiftades var de framför allt tänkta att gälla skriftliga avtal och inte digitala avtal skrivna i kod som utförs på en blockkedja. När sådant avtal ingås aktualiseras därför frågan om de är tillåtna enligt gällande lagstiftning. För att ingå ett avtal enligt AvtL måste bland annat en viljeförWhen entering an agreement the Contracts Act becomes applicable, and Consumer Contracts Act if it concerns a consumer and a trader. When the laws were enacted they were mainly made for written agreements, and not for Smart Contracts consisting of computer code that are programmed to execute transactions. When these types of contracts are made it brings to the fore if they are to be considered lega
I fallet HFD 2021 ref. 33 var problematiken angående överlåtelser av under-skottsföretag en central punkt. Fallet, även kallat Hoist-målet, hanterade frågan om huruvida en överlåtelse av ett underskottsföretag stred mot reg-lerna i 40 kap. IL alternativt skatteflyktslagen. HFD fann att så inte var fal-let, och biföll Hoists överklagan av den tidigare fällande domen. Fallet resul-terade i stora disIn the case HFD 2021 ref. 33 the issues regarding transactions of tax-deficient companies were a focal point. Also referred to as the Hoist-case, it dealt with the question of whether a transaction of a tax-deficient company was incompatible with the rules in the 40th chapter IL as well as the tax eva-sion act. HFD found that this was not the case and ruled in favour of Hoist, approving the transa
Heart rate is today measured in various ways, but they all include contact with the skin. Measuring heart rate contactless would be a more efficient method in healthcare and would also benefit people suffering from skin problems. It has been proven that it is possible to use radar to measure heart rate. The aim of this thesis is to investigate how to extract the heart rate with a 60 GHz pulsed coh
