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Spatial Planning and Sociology of Law: Sustainable development issues in constructing infrastructure for the third generation mobile telephone system in Sweden

The infrastructure for the third generation of mobile telephony, UMTS, is under construction in Sweden. Within three years four operators were to build competing systems to cover 99,98 % of the population. The case of the 3G infrastructure illustrates how sustainability issues are handled in planning and environmental management, with conflicting goals between institutional levels and contradict

Modeling sediment storage and transfer for simulating regional coastal evolution

he regional coastal evolution model Cascade was enhanced to better describe the transfer and storage of sediment. Focus was on the cross-shore exchange of material from the subaerial to the sub-aqueous portion of the beach and on shoal evolution at coastal inlets. Cross-shore material exchange now includes erosion due to wave impact and overwash, and barrier and dune build-up by wind. Cascade was

High-level bacterial secretion of single-chain αβ T-cell receptors

While numerous antibody-antigen systems have been structurally characterized, studies of structurally analogous T-cell receptor MHC systems have lagged behind largely due to the lack of a general TCR expression system. Efforts to develop bacterial systems have resulted in low yields (< 0.5 mg/l) of active material which is prone to proteolysis and aggregation. Here we report a strategy to secrete

Retrofitting Electrically Heated Single-Family Houses to Net-Zero Energy

Only in Sweden, single-family houses account for approximately 30% of energy use in all buildings and a large part uses only electricity for heating. The potential for improvements on energy efficiency in these houses is large. This study theoretically investigates retrofitting of electrically heated Swedish single-family houses by using an air-source heat pump for both space heating and domestic

Neutrophil-derived heparin binding protein-A mediator of increased vascular permeability after burns?

Increased vascular permeability and oedema formation constitute a major clinical challenge following burns. Several clinical studies show that leukocytes are systemically activated following burns. Neutrophils have the capability to increase vascular permeability via mechanisms thought to involve the release of heparin binding protein (HBP). We hypothesised that HBP is elevated in plasma after maj

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species

Cytoplasmic protein-tyrosine kinases (PTKs) are enzymes involved in transducing a vast number of signals in metazoans, The importance of the Tec family of kinases was immediately recognized when, in 1993, mutations in the gene encoding Bruton's tyrosine kinase (Btk) were reported to cause the human disease X-linked agammaglobulinemia (XLA).((1,2)) Since then, additional kinases belonging to this f

Mating system variation and morph fluctuations in a polymorphic lizard

In polymorphic male painted dragon lizards (Ctenophorus pictus), red males win staged contests for females over yellow males, and yellow males have greater success in staged sperm competition trials than red males. This predicts different reproductive strategies in the wild with red males being more coercive or better mate guarders than yellow males. Yellow males would be expected to sire more off

Clinical rating of dyskinesias in Parkinson's disease: use and reliability of a new rating scale

Drug-induced dyskinesias (DID) manifested as hyperkinetic and/or dystonic movements or postures are common problems in Parkinson's disease (PD). Novel therapeutic interventions may offer possibilities to counteract these common adverse effects of an otherwise necessary treatment. To be able to evaluate the effects of such interventions on DID, reliable and relevant clinical assessment tools are ne

Stability of immobilized Candida antarctica lipase B during chemo-enzymatic epoxidation of fatty acids

The parameters affecting the lipase activity and operational lifetime during chemo-enzymatic epoxidation of fatty acids were investigated. Immobilized Candida antarctica lipase B (Novozym (R) 435) was incubated in the presence of various reaction components (i.e. toluene, water, H2O2, oleic acid, perpalmitic acid, and epoxystearic acid, respectively) at temperatures between 20 and 60 degrees C fol

Modelling heat transfer in a bone-cement-prosthesis system

The heat transfer in a general bone-cement-prosthesis system was modelled. A quantitative understanding of the heat transfer and the polymerization kinetics in the system is necessary because injury of the bone tissue and the mechanical properties of the cement have been suggested to be effected by the thermal and chemical history of the system. The mathematical model of the heat transfer was base

Histology of impacted bone-graft incorporation

We describe the histologic findings of 31 tissue samples from 21 cases in 19 different patients taken 1 to 48 months after revision arthroplasty and impaction grafting in the hip (Lubinus SP-II prosthesis Waldemar Link, Hamburg, Germany, or Charnley Elite prosthesis, Johnson & Johnson, New Brunswick, NJ) and the knee (Link Rotation Knee Waldemar Link). One month after surgery, a fibrous stroma

A pilot study of facial, cranial and brain MRI morphometry in men with schizophrenia: Part 2.

This pilot study applies a new 3D morphometric MR method to test the hypothesis that men with schizophrenia (vs. controls) have deviant facial shapes and landmark relations in cranio/facialibrain (CFB) regions. This constitutes Part 2 of paired articles in this issue of Psychiatry Research: Neuroimaging, in which Part 1 presents the new method in detail. MRI coordinates from CFB landmarks of 23 pa

Novel homogenous time-resolved fluorometric RT-PCR assays for quantification of PSA and hK2 mRNAs in blood

Objectives: The purpose of this study was to design, validate, and optimize internally standardized real-time quantitative RT-PCR assays and to identify and avoid problems with assay reliability and examine the impact of an exogenous internal standard. Design and methods: The model system consisted of internally standardized quantitative real-time RT-PCR assays specific for PSA and hK2 mRNA based

Neuroprotective effects of the beta-carboline abecarnil studied in cultured cortical neurons and organotypic retinal cultures.

Presently there is no neuroprotective pharmacological treatment of proven clinical safety and efficacy available. The purpose of this study was to investigate whether the ss-carboline, abecarnil (Abe), which has already passed clinical phase III trials in patients with anxiety disorders, is neuroprotective in in vitro models of cerebral ischemia or excitotoxicity. Abe (100 nM) protected cultured c

Monitoring of atherosclerosis

Population-based epidemiological studies of atherosclerosis using autopsy material is now impossible to perform in most countries due to declining autopsy rates. Based on epidemiological studies of atherosclerosis using autopsy material in five European cities which were carried out with an interval of 25 years in the 1960s and 1980s, respectively, we have shown that atherosclerosis in young so-ca

An okadaic acid-sensitive protein phosphatase counteracts protein kinase C-induced phosphorylation in SH-SY5Y cells

Protein phosphorylation and subsequent dephosphorylation was studied in digitonin-permeabilized neuroblastoma SH-SY5Y cells by measuring the incorporation of [32P]phosphate into myelin basic protein (MBP). 1,2-Dioctanoyl-sn-glycerol (DOG) and calcium synergistically induced phosphorylation of MBP, which was inhibited by the protein kinase C (PKC) pseudosubstrate peptide (PKC19-36). The phosphoryla

Search for a Heavy Particle Decaying into an Electron and a Muon with the ATLAS Detector in root s=7 TeV pp collisions at the LHC

This Letter presents the first search for a heavy particle decaying into an e(+/-)mu(-/+) final state in root s = 7 TeV pp collisions at the LHC. The data were recorded by the ATLAS detector during 2010 and correspond to a total integrated luminosity of 35 pb(-1). No excess above the standard model background expectation is observed. Exclusions at 95% confidence level are placed on two representat

Hydraulic and Thermal Simulations of a Cross-Corrugated Plate Heat Exchanger Unitary Cell

Simulations have been carried out by means of computational fluid dynamics for turbulent convective heat transfer in a cross-corrugated plate pattern heat exchanger unitary cell at a Reynolds number of 4930. Chen's high-Reynolds-number k-E model, the Reynolds stress model (RSM), Suga's low-Reynolds-number k-E model, and the V2F model were used. The predicted hydraulic and thermal behaviors using t

The Influence of Specimen Size and Distance to a Surface on Resistive Moisture Content Measurements in Wood

The moisture content of wood is commonly determined by measuring the electrical resistance between two electrodes inserted in the wood. However, problems using this method close to wood surfaces were reported in a previous study. In the present study, the effect of the distance to a surface and the specimen size on the measured electrical resistance was studied analytically as follows. The two ele

Cytoplasmic HIF-2α as tissue biomarker to identify metastatic sympathetic paraganglioma

Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors. PGLs can further be divided into sympathetic (sPGLs) and head-and-neck (HN-PGLs). There are virtually no treatment options, and no cure, for metastatic PCCs and PGLs (PPGLs). Here, we composed a tissue microarray (TMA) consisting of 149 PPGLs, reflecting clinical features, presenting as a useful resource. Mutations