Filtyp
Metabolism plays a central role in evolution, as resource conservation is a selective pressure for fitness and survival.Resource-driven adaptations offer a good model to study evolutionary innovation more broadly. It remains unknown howresource-driven optimization of genome function integrates chromatin architecture with transcriptional phase transitions.Here we show that tuning of genome architec
Given a directed graph as input, we show how to efficiently find a shortest (directed, simple) cycle on an even number of vertices. As far as we know, no polynomial-time algorithm was previously known for this problem. In fact, finding any even cycle in a directed graph in polynomial time was open for more than two decades until Robertson, Seymour, and Thomas (Ann. of Math. (2) 1999) and, independ
There are plenty of books and articles on research methods, but few discuss the nature and purpose of method sections in academic journals. Based on interviews with critical and interpretivist researchers, this short paper examines the nature and purpose of method sections in management and organization studies. We show how researchers make sense of, and struggle with, positivist expectations abou
Spridningskoefficienter baserade på färgförsök beräknas
In this paper, we explore cybersecurity from a sociotechnical work-system perspective and focus on the visibility and effectiveness of security practices as part of the everyday work practices of typical employees. The empirical inquiry involved 471 employees from 259 different organizations, drawn from both private and public sectors using semi-structured interviews and conducted from an interpre
A central role for sexual isolation in the formation of new species and establishment of species boundaries has been noticed since Darwin and is frequently emphasized in the modern literature on speciation. However, an objective evaluation of when and how sexual isolation plays a role in speciation has been carried out in few taxa. We discuss three approaches for assessing the importance of sexual
In general, the word, photosynthesis, is considered synonymous with oxygenic photosynthesis, a process by which cyanobacteria, algae, aquatic, and terrestrial plants produce oxygen and carbohydrates, using light (photons), water and carbon dioxide. Further, we have anoxygenic bacterial photosynthesis where oxygen is not evolved, but a substrate, other than water, is oxidized, and rhodopsin-type sy
Cocaine and amphetamine-regulated transcript (CART) is expressed in pancreatic islet cells and neuronal elements. We have previously established insulinotropic actions of CART in human and rodent islets. The receptor for CART in the pancreatic beta cells is unidentified. We used RNA sequencing of Cartpt knockdown (KD) INS-1 832/13 cells and identified GPR162 as the most Cartpt-regulated receptor.
BACKGROUND: Several molecular classification systems for bladder cancer have been proposed, but due to differences on how to define molecular subtypes, controversies and misunderstandings have arisen. OBJECTIVE: To discuss different aspects of the molecular classification of bladder cancer and to point to the consequences of using different conceptual approaches. To question some underlying assump
Caffeine acts as a central nervous stimulant by blocking A1 and A2A adenosine receptors. Its effect on seizures is complex. Animal studies and case reports indicate that acute caffeine exposure may induce seizures, whereas chronic exposure might have an opposite effect. Patients acutely hospitalized for seizures (n=174) were asked for their consumption of caffeinated beverages 24. h prior to admis
The presence of overlapping elements in distinct events promotes the formation of associative inferences across event boundaries, thereby shaping how new information is integrated with pre-existing knowledge. This study investigates the influence of schema congruency on mnemonic processes involved in such associative inferences.The present study employed EEG recordings of brain activity to assess
A key issue in sexual selection theory is how a correlation between male secondary sexual characters and male genetic quality can be maintained. The immunocompetence-handicap hypothesis proposes that testosterone-dependent male characters remain honest signals because of the immunosuppressive effect of elevated steroid hormone levels. The hypothesis requires that physiological levels of testostero
Can AI ‘solve’ politics? In this paper, I explore optipolitics, i.e., the idea that politics along with other complex social issues can be framed as mathematical optimization problems and solved as such. I begin by describing politics, optimization, and some reasons for applying the latter to the former. I then present a liberal democratic version of optipolitics and try to defend it against eight
Artificially cultivated meat may have environmental benefits and harm-reductive capabilities, making it crucial to establishing ethical food production practices. However, we argue that salient factors make producing and consuming artificially cultivated meat morally problematic. We detail some of these factors and highlight their roots in different ethical traditions. These factors present seriou
Depressive/anxiety disorders are the most common types of mental illnesses in the world. The present study was the first to explore the association between plasma microRNAs (miRNAs) and depression/anxiety in primary care patients.
This article applies a global value-chain framework to the tobacco industry in Malawi, showing how cigarette manufacturers govern the chain and control first-tier suppliers, the leaf merchants. Contract farming offers smallholders the ability to meet manufacturers' compliance and traceability requirements and an opportunity for process and product upgrading, but threatens to exclude poorer growers
