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The levels and conformers of alpha-synuclein are critical in the pathogenesis of Parkinson's Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation and secretion have been identified as regulators of alpha-synuclein at different stages of its intracellular trafficking and transcellular propagation. Here we review pathways involved in the removal of various forms of al

Axonal degeneration, which contributes to functional impairment in several disorders of the nervous system, is an important target for neuroprotection. Several individual factors and subcellular events have been implicated in axonal degeneration, but researchers have so far been unable to identify an integrative signaling pathway activating this self-destructive process. Through pharmacological an

Background: C. pseudotuberculosis is an important animal pathogen that causes substantial economical loss in sheep and goat farming. Zoonotic infections in humans are rare, but when they occur they are often severe and difficult to treat. One of the most studied proteins from this bacterium, the secreted protein CP40 is being developed as a promising vaccine candidate and has been characterized as

The Fourier dimension is not, in general, stable under finite unions of sets. Moreover, the stability of the Fourier dimension on particular pairs of sets is independent from the stability of the compact Fourier dimension.

BACKGROUND: Phosphorylation plays an essential role in regulating voltage-gated sodium (Na(v)) channels and excitability. Yet, a surprisingly limited number of kinases have been identified as regulators of Na(v) channels. We posited that glycogen synthase kinase 3 (GSK3), a critical kinase found associated with numerous brain disorders, might directly regulate neuronal Na(v) channels.METHODS: We u

Contrary to the notion that altering our ordinary state of consciousnessnecessarily produces delusional beliefs and is generally deleterious, variousfindings in psychology and other disciplines suggest that 1) the ordinary stateof consciousness does not provide an accurate mapping of reality and 2) alterationsof consciousness can have various positive functions. Among themost important ones are to

Robert Alexy’s theory of legal argumentation is among the notable contributions made to mainstream jurisprudence in the last three decades. Remaining true to its rational discursive mission, it engages with both analytical positivism and natural law theories. A recent collection of essays edited by George Pavlakos explores Alexy’s theory from a number of philosophical standpoints, revealing its th

This paper claims that formal features do not belong to syntax. A revised version of the paper has the title 'Remarks on feature', see http://ling.auf.net/lingBuzz/000334

Abstract in UndeterminedContrary to the notion that altering our ordinary state of consciousness necessarily produces delusional beliefs and is generally deleterious, various findings in psychology and other disciplines suggest that 1) the ordinary state of consciousness does not provide an accurate mapping of reality and 2) alterations of consciousness can have various positive functions. Among t

The term ‘path dependence’ is generally used to describe the development of technological standards and how they ‘lock in’ a given technical solution. The QWERTY keyboard is often given as an example of path dependence – the fact that the costs of changing the keyboard to a better, more efficient solution, hinders change. The same can be said about much of the copyright legislation today, but then