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This study was undertaken to determine whether the production of melatonin, a hormone regulating sleep in relation to the light/dark cycle, is altered in Huntington's disease. We analyzed the circadian rhythm of melatonin in a 24-hour study of cohorts of control, premanifest, and stage II/III Huntington's disease subjects. The mean and acrophase melatonin concentrations were significantly reduced
This paper demonstrates how nostalgia entices consumers to re-circulate objects rather than discard them. Through multimethod qualitative inquiry into the Danish vintage cycling community, this paper highlights how consumers’ nostalgic attachment to the biographies of old objects propels re-circulation. The analysis builds on three distinct modes of nostalgia: reluctant, progressive, and playful n
In the last column, we promised to return to one of the inevitable challenges that vibe coding leaves us with. At the AI Engineer World’s Fair 2025, OpenAI’s Sean Grove claimed that whoever writes the specification is now the programmer since AI can take it from there. Sounds amazing, but what gets lost along the way? To explore this, I’m joined by Jan-Philipp Steghöfer, a researcher at XITASO and
It is generally agreed upon that social trust is strongly associated with income inequality. However, this conclusion is mainly drawn from cross-country studies, which most likely suffer from endogeneity issues due to unobserved cultural, social and political variables affecting both trust and inequality. In this paper we collect trust data from six different surveys and make them comparable throu
Language is a social act and the fact that social communities create new or change existing words that are known in daily standard language, can make the lexicon difficult to comprehend for the ones not involved. The communication that belong to a specific social group can be classified as a jargon, and in this present study we look at gaming language as an example of how social communities’ lexic
Risk and risk aversion are crucial concepts in finance. Models in finance typically assume a known probability distribution of returns, which does often not hold in reality. This papers aims to measure the uncertainty surrounding the probability distribution in equity markets and to evaluate if such uncertainty is priced. Our study defines uncertainty as the volatility of the option implied volati
This paper is one in a series of experimental studies on the effects of food composition on aging and longevity, using the golden-haired blowfly Calliphora stygia as the animal model Here we examine how diet. fat content affects blowfly life history traits such as longevity, reproduction, feeding rate, body mass, total fat content and membrane fatty acid composition. The highest median and maximum
The tumor suppressor PTEN antagonizes phosphatidylinositol 3-kinase (PI3K), which contributes to tumorigenesis in many cancer types. While PTEN mutations occur in some melanomas, their precise mechanistic consequences have yet to be elucidated. We sought to identify novel downstream effectors of PI3K using a combination of genomic and functional tests. Microarray analysis of 53 melanoma cell lines
Small cell lung carcinoma (SCLC) is extremely aggressive and frequently metastasizes widely in its early stage. Because tumor hypoxia is related to aggressive tumor behavior and the hypoxic adaptation of SCLC is poorly documented, we stained SCLC tumors arranged in a tissue microarray for hypoxia-inducible factor (HIF)-1α and HIF-2α proteins. We found an overall lack of HIF-2α protein expression,
The Erasmus exchange is a recent phenomena that has seen a steady growth in participation, and it seems that it is just a matter of time before it will be a fundamental part of students’ life. The participation of young Europeans to such exchange gives them the possibility to experiment a new, more direct way of living Europe. My thesis wants to analyse how study exchanges are shaping the percepti
Den här uppsatsen syftar till att föreslå en alternativ diskurs om normbrytande funktionsvariationer. I analys av intervjufilmer med familjer där det finns en familjemedlem med en normbrytande funktionsvariation undersöks hur en nuvarande dominerande diskurs verkar förtryckande. Vidare föreslås en språklig vändning som riktar blicken mot uteslutande strukturer snarare än att fokusera på individen
The sharing economy has emerged as a potential way to reduce the environmental impact and costs of using products, whilst increasing their accessibility. However, there is a paucity of literature on its sustainability implications. To help fill this void we provide a first indicative assessment of the potential sustainability implications for the sharing of three product groups in Sweden, namely c
The fate of the Masurian Lutherans in eastern Poland is one of the tragedies of modern Europe. This chapter monitors the various, and often contradictory, attempts to transform a group that often escaped attempts at cultural and political classification. During the post-WWII era, various efforts to support this group were made by the part of European co-religionists. In this chapter is found a fir
Insulinlike growth factor. 1 (IGF-1) has growth-promoting effects on myeloma cells in vitro as well as in vivo. In this study, we measured the concentration of IGF-1 and its major binding protein, IGF-binding protein 3 (IGFBP-3), in serum from 127 patients with multiple myeloma. Serum had been drawn at the time of diagnosis, before treatment With highdose melphalan. IGFBP-3 in myeloma patients (1.
INTRODUCTION: Post-traumatic stress disorder (PTSD) has been associated with immune disturbances, including a higher incidence of infections and autoimmune diseases as well as a net pro-inflammatory state. Natural killer (NK) cells, a key component of the innate immune system, have been less well-studied in PTSD despite their importance in immunity.METHODS: We studied two independent samples of co
