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OBJECTIVE: To compare costs of transurethral prostatic resection (TURP) and transurethral microwave thermotherapy (TUMT) for symptomatic benign prostatic hyperplasia (BPH) in a randomized, controlled trial. METHODS: In 70 BPH patients all costs were calculated for management, including complications and repeat treatment, during TURP or TUMT and 24-month follow-up. Clinical outcome was judged from

Components derived from cartilage have been suggested to maintain the inflammation in joints in arthritis. Small leucine-rich repeat proteins (SLRPs) are structural components of cartilage important in organizing the meshwork of extracellular matrix components. It has recently been shown that the SLRP fibromodulin interacts with complement initiator C1q, leading to complement activation. The compl

The proportion of CD4- CD8- double-negative (DN) alpha beta T cells is increased both in the thymus and in peripheral lymphoid organs of TCR alpha chain-transgenic mice. In this report we have characterized this T cell population to elucidate its relationship to alpha beta and gamma delta T cells. We show that the transgenic DN cells are phenotypically similar to gamma delta T cells but distinct f

Background Knowledge about how elderly persons perceive the impact of chronic heart failure (CHF) on daily life is important when planning nursing care. For this purpose, disease specific instruments are needed. However, few instruments have been developed or tested specifically on elderly persons. Aim To validate a Swedish version of the Minnesota Living with Heart Failure Questionnaire (LHFQ)

The appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or hyperglycaemias and ultimately diabetes. Here, we review beta-cell glucose-sensing with a particula

The view on reactive oxygen species (ROS) in inflammation is currently shifting from being considered damaging toward having a more complex role in regulating inflammatory reactions. We recently demonstrated a role of ROS in regulation of animal models for the autoimmune disease rheumatoid arthritis. Low levels of ROS production, due to a mutation in the Ncf1 gene coding for the Ncf1 (alias p47pho

Human polyclonal and monoclonal antibodies against pathogens and toxins are potentially useful in the treatment of various diseases. A number of human monoclonal antibodies with protective capacity in vitro have been established by conventional hybridoma technology. However, with the development of phage-display technology, the possibility of specifically tailoring antigen-binding properties has i

Type 1 diabetes is a common, multifactorial disease with strong familial clustering (genetic risk ratio [{lambda}S] ~ 15). Approximately 40% of the familial aggregation of type 1 diabetes can be attributed to allelic variation of HLA loci in the major histocompatibility complex on chromosome 6p21 (locus-specific {lambda}S ~ 3). Three other disease susceptibility loci have been clearly demonstrated

Antibody evolution in vivo proceeds mainly by stepwise improvements, accomplished by single base pair substitutions. Lately, receptor revision, i.e. exchange of large parts of the V gene for another sequence, has been suggested to provide a complementary route for affinity maturation. By employing a receptor revision like evolution process in vitro using combinatorial libraries and phage display s

Conventional road accident risk is measured by the undesirable events/exposure ratio. Common exposure indicators are activity-based, so event-based exposure is needed to achieve event-based safety assessment. Furthermore, road safety simulation is a growing research field. The influence of some software parameters is still unknown. Besides, the use of simulation for exposure assessment is incipien

Sizeable number of stellar-mass black holes (BHs) in globular clusters (GCs) can strongly influence the dynamical evolution and observational properties of their host cluster. Using results from a large set of numerical simulations, we identify the key ingredients needed to sustain a sizeable population of BHs in GCs up to a Hubble time. We find that while BH natal kick prescriptions are essential

The pyISC is a Python API and extension to the C++ based Incremental Stream Clustering (ISC) anomaly detection and classification framework. The framework is based on parametric Bayesian statistical inference using the Bayesian Principal Anomaly (BPA), which enables to combine the output from several probability distributions. pyISC is designed to be easy to use and integrated with other Python li

Purpose: People with acquired neurogenic Communication Disorders (PwCD) experience reduced satisfaction in healthcare environments, possibly relating to communication difficulties. Communication Partner Training might improve communication success. The purpose of the scoping review was to map the literature about educational experiences in teaching communication strategies to healthcare students (

The article contributes to the research of platformisation of everyday life and children’s television use by exploring how 0-3-year-olds’ television viewing on screen media is embedded in daily social practices of families in Sweden. The article examines the research questions: 1) What social practices are organised around young children’s television viewing on screen media? 2) How can these telev

Abstract The purpose of the study is to examine if the use of state aid in the EU have increased or decreased and especially the use of state aid to support the manufacturing sector. The development of total state aid in relation to GDP and sectoral distribution of total aid are studied. So is state aid to the manufacturing sector and its different objectives and forms, since this sector is grante

Objectives: The aim of this study was to evaluate our experience with patients affected by ovarian carcinosarcoma. Patients and Methods: During a 16-year period, data on 13 patients with ovarian carcinosarcoma were collected. They were obtained from hospital charts and follow-up visits. Survival curves were estimated by the Kaplan-Meier method and compared using the log-rank test. All tests were t

Local adaptation in hermaphrodite species can be based on a variety of fitness components, including survival, as well as both female and male sex-functions within individuals. When selection via female and male fitness components varies spatially (e.g. due to environmental heterogeneity), local adaptation will depend, in part, on variation in selection through each fitness component, and the exte