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Rationale. The value of microRNAs (miRNAs) as biomarkers has been addressed in various clinical contexts. Initial studies suggested that miRNAs, such as the brain-enriched miR-124-3p, might improve outcome prediction after out-of-hospital cardiac arrest. The aim of this study is to determine the prognostic value of miR-122-5p in a large cohort of comatose survivors of out-of-hospital cardiac arres

It is well documented that human modification of the hydrological cycle has profoundly affected the flow of liquid water across the Earth's land surface. Alteration of water vapor flows through land-use changes has received comparatively less attention, despite compelling evidence that such alteration can influence the functioning of the Earth System. We show that deforestation is as large a drivi

Background/Aim: To compare human papillomavirus (HPV) DNA detection in self-collected vaginal and urine samples with clinician-taken cervical samples in relation to histology. Materials and Methods: Self-collected vaginal, urine and clinician-taken cervical samples were analyzed from 218 women with the Cobas 4800 HPV test (Roche Molecular Diagnostics). Results: The sensitivity for detection of HPV

The discovery, in 2004, of extracellular traps released by neutrophils has extended our understanding of the mode of action of various innate immune cells. This fascinating discovery demonstrated the extracellular trapping and killing of various pathogens by neutrophils. During the last decade, evidence has accumulated showing that extracellular traps play a crucial role in the defence mechanisms

Background: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA.

University incubators are an opportunity to promote the dissemination of research, change teaching practices and contribute to territorial economic development. In this article we present a structural and dynamic analysis of such an innovation system of a Swedish eco-innovation system by proposing elements for analysing the success of such innovation systems.

Sexual selection hypotheses stipulate that the major histocompatibility complex genes (MHC) constitute a key molecular underpinning for mate choice in vertebrates. The last four decades saw growing empirical literature on the role of MHC diversity and dissimilarity in mate choice for a wide range of vertebrate animals, but with mixed support for its significance in natural populations. Using forma

Sammanfattning Det är enbart arbetstagare som omfattas av det arbetsrättsliga skyddet i lagstiftningen. Därmed utgör arbetstagarbegreppet en viktig del av arbetsrätten. Definitionen av begreppet får en allt större betydelse då sättet att organisera arbetet förändras kontinuerligt i och med att nya anställningsformer tillkommer. Uppsatsen undersöker hur EU och Sverige definierar och tillämpar arbAbstract The Labour law protection only covers those who are considered employees. Thus, the concept of employee is a significant part of the Labour law. The definition is becoming increasingly important as the way of organizing the work is continuously changing as new forms of employment are added. The essay examines how the EU and Sweden define and apply the concept of employee and what similar

Maternal alloantibody-induced hemolytic disease of the fetus and newborn (HDFN) remains a significant concern worldwide. Alloimmune HDFN can be pathogenetically named by the specific alloantibodies involved. Moreover, four mechanistic pathway types are generally recognized in clinical practice: classical or extravascular hemolysis; immune-pressure-escaped, also known as antibody-mediated antigen-m

Background: Atherosclerotic cardiovascular disease is a chronic inflammatory process initiated when cholesterol-carrying low-density lipoprotein (LDL) is retained in the arterial wall. CD4+ T cells, some of which recognize peptide components of LDL as antigen, are recruited to the forming lesion, resulting in T-cell activation. Although these T cells are thought to be proatherogenic, LDL immunizat

Abstract – Background: Cytologic examination of lymph nodes and serous effusions is of value in the diagnosis of small cell lymphomas. The World Health Organisation (WHO) has recently published a reporting system relating to the cytologic examination of lymph nodes, spleen, and thymus to standardise the approach to reporting such specimens. Summary: An overview of the WHO reporting system is given

T-helper 2 (Th2) cell responses defend against parasites. Although dendritic cells (DCs) are vital for the induction of T-cell responses, the DC subpopulations that induce Th2 cells in the intestine are unidentified. Here we show that intestinal Th2 responses against Trichuris muris worms and Schistosoma mansoni eggs do not develop in mice with IRF-4-deficient DCs (IRF-4f/f CD11c-cre). Adoptive tr

PURPOSE: This study investigated the value of intense follow-up compared with no follow-up after curative surgery of cancer in the colon or rectum. METHODS: One hundred seven patients were randomized to no follow-up (control group; n=54) or intense follow-up (follow-up group; n=53) after surgery and early postoperative colonoscopy. Patients in the follow-up group were followed at frequent interval

Theory predicts democracy should reduce corruption. Yet, scholars have found that while corruption is low at high levels of democracy, it is high at modest levels, as well as low when democracy is absent. A weakness of studies that aim to explain this inverted curvilinear relationship is that they do not disaggregate the complex concepts of democracy and corruption. By contrast, this paper disaggr

There is a clinical need for improved wound treatments that prevent both infection and excessive inflammation. TCP-25, a thrombin-derived peptide, is antibacterial and scavenges pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide, thereby preventing CD14 interaction and Toll-like receptor dimerization, leading to reduced downstream immune activation. Here, we describe the de