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Proteolysis plays an important role in mitochondrial biogenesis, from the processing of newly imported precursor proteins to the degradation of mitochondrial targeting peptides. Disruption of peptide degradation activity in yeast, plant and mammalian mitochondria is known to have deleterious consequences for organism physiology, highlighting the important role of mitochondrial peptidases. In the p

Palmitoyl-protein thioesterase 1 (PPT1) is a depalmitoylation enzyme that is mutated in cases of neuronal ceroid lipofuscinosis (NCL). The hallmarks of the disease include progressive neurodegeneration and blindness, as well as seizures. In the current study, we identified 62 high-confident PPT1-binding proteins. These proteins included a self-interaction of PPT1, two V-type ATPases, calcium volta

This paper investigates the relation between organizational change and enacted or experienced workplace bullying. We find that there is a longitudinal relation between organizational change and bullying behaviour and that this effect varies depending on the type of preceding organizational change (task-related or relational change). Task-related change predicts experienced bullying behaviours and

There is a large consensus that higher education institutions exert notable effects on their regional environment. So far, however, much of the related evidence is based on case studies. Few findings are available on a more generalizable level. To bridge this gap, our study uses spatial panel-data models to identify the impacts of higher education institution (HEI) activities on GDP per capita and

Diabetic kidney disease is one of the major complications associated with diabetes. Approximately 25-40% of both type 1 and type 2 diabetes patients will acquire a kidney complication and despite global efforts to reduce the prevalence of diabetic kidney disease, it is a leading cause of kidney failure in the western world. There are few treatment options directly targeting the kidney.The overall

Deoxyribonucleoside kinases (dNKs) salvage deoxyribonucleosides (dNs) and catalyze the rate limiting step of this salvage pathway by converting dNs into corresponding monophosphate forms. These enzymes serve as an excellent model to study duplicated genes and their evolutionary history. So far, among vertebrates only four mammalian dNKs have been studied for their substrate specificity and kinetic

The aim of this thesis was to examine the effect of sleep on emotional memories. The first two studies examined the role of sleep in the generalization of fear learning and the third study examined how sleep affected the forgetting of unwanted emotional memories.In study 1, participants first underwent fear conditioning with a small and a large circle as the CS+ and the CS-. Next, after either a n

Chinese private schools may come across as a contradictory phenomenon: why would an authoritarian and officially socialist government, that needs to rely on education as an instrument of national unification and ideological control, allow for private schools and profit-making in the educational sector? However, seen against the background of the far-reaching privatisation processes that have been

We report here genome sequences and comparative analyses of three closely related parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. tongicomis. Parasitoids are important regulators of arthropod populations, including major agricultural pests and disease vectors, and Nasonia is an emerging genetic model, particularly for evolutionary and developmental genetics. Key findings include the ide

Socio-economic inequalities are remarkable in contemporary developed countries and continue to grow. The sources of these phenomena are not understood, and there is no agreement as to when in an individual’s life they originate, from early childhood to adulthood. The literature showing that health in infancy may be an important factor in later-life health and income trajectories is expanding, but

In this paper, we have investigated, by means of quantitative and statistical methods, stability and change in cultural vocabulary of Indo-European in Europe, with a focus on agriculture. For this purpose we have created a culture vocabulary list with lexical head words, organized into subcategories based on their role and function in a cultural system, the purpose of which is to give a representa

The Mesozoic biotas of Scandinavia have been studied for nearly two centuries. However, the last 15 years have witnessed an explosive advance in research, most notably on the richly fossiliferous Triassic (Olenekian-Carnian) and Jurassic (Tithonian) Lagerstätten of the Norwegian Arctic Svalbard archipelago, Late Cretaceous (Campanian) Kristianstad Basin and Vomb Trough of Skåne in southern Sweden,

The effect of doping and diameter on the electrical properties of vapor-liquid-solid grown GaSb nanowires was characterized using long channel back-gated lateral transistors and top-gated devices. The measurements showed that increasing the doping concentration significantly increases the conductivity while reducing the control over the channel potential and shifting the threshold voltage, as expe

This paper investigates the effects of multinationality on firm productivity, and contributes to the literature in two respects. First, we argue that multinationality affects productivity both directly and indirectly through higher incentives to invest in R&D. Second, we maintain that the multinational depth and breadth have different direct effects on productivity and R&D. Using data from

This article examines the contours of how sex-selective abortion (SSA) and ‘gendercide’ have been problematically combined within contemporary debates on abortion in Europe. Analysing the development of policies on the topic, we identify three ‘turns’ which have become integral to the biopolitics of SSA in Europe: the biomedical turn, the ‘gendercide’ turn, and the Asian demographic turn. Recent a

We study common features in the income velocity of money, income, and interest rates for Canada, the U.S., the U.K., Sweden and Norway using annual data from 1870. The recently developed and refined techniques of testing for cointegration are employed.The evidence suggests there is a unique long-run relationship in velocity but not in income and interest rates. Moreover, we find that only a model

The purpose of this paper is to study the determination of annual changes in the money wage rate and in the price level in Sweden during the period 1922–1971. We have chosen to examine such a long span of years in order to make comparisons between various time periods and to investigate to what extent a given set of explanatory variables can account for the movements in wages and prices during the