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This review examines evidence that rheumatoid arthritis (RA) depends on autoimmunity to articular collagen, and mechanisms whereby autoantibodies to type II collagen contribute to disease development. Three major autoantigenic reactants have been identified in RA; the corresponding autoantibodies are rheumatoid factor (RF), antibodies to citrullinated peptide antigens (ACPA), citrullinated peptide

Erythroblast transformation-specific domain (ETS) transcription factors regulate some of the critical molecular mechanisms controlling the differentiation of multipotent haematopoietic progenitor cells into effector B-lymphocytes. The SPI-group ETS-protein transcription factors PU.1 and SPI-B play essential and, although coexpressed and binding to similar DNA sequences, unique roles in B-cell diff

This paper describes the implementation of a structure assessmentmethod in an industrial control system. The method uses available signals to evaluate if a given signal can be used for additional feed forward control action to improve the performance of a control loop.

The neuropeptide WE-14 is derived from the posttranslational processing of chromogranin A (CgA). While CgA is expressed in a preponderance of neuroendocrine cells, WE-14 is generated in a distinct subpopulation of CgA-immunopositive cells, most notably in the adrenal, pituitary, and parathyroid glands. Physiological and pharmacological studies have demonstrated that CgA is cleaved to generate WE-1

Sterile liver inflammation and fibrosis are associated with many liver disorders of different etiologies. Both type 1 and type 2 inflammatory responses have been reported to contribute to liver pathology. However, the mechanisms controlling the balance between these responses are largely unknown. Natural killer T (NKT) cells can be activated to rapidly secrete cytokines and chemokines associated w

Migration is an important global phenomenon fostering entrepreneurship. Migrants are individuals who are moving or have moved across an international border, or nationally across different regions or provinces, away from their habitual place of residence (UN Migration Agency, 2019). These individuals are considered migrants regardless of what their legal status is, whether the movement is voluntar

The majority of herbivorous insects are specialized in host use. Even among insects that use many hosts, local specialization is common with a single host plant often being used in any given locality. Here, we establish such a pattern for the European swallowtail butterfly, Papilio machaon. We sampled larvae on five different natural hosts at eight sites in Sweden, each locality showing local mono

This chapter establishes four evaluative themes that will be employed across this volume to analyze the institutional complexity of policy fields in the climate-energy nexus: coherence, management, legitimacy, and effectiveness. Coherence among institutions is conceptualized along four dimensions: convergence on an overarching core norm for the policy field, balanced coverage and distribution of m

We investigate the dissolution process of star clusters embedded in an external tidal field and harboring a subsystem of stellar-mass black hole. For this purpose we analyzed the MOCCA models of real star clusters contained in the Mocca Survey Database I. We showed that the presence of a stellar-mass black hole subsystem in tidally filling star cluster can lead to abrupt cluster dissolution connec

The question of who China’s leftover men will marry is becoming a pressing issue for Beijing. The government’s response will shape the country’s future for decades to come.

BACKGROUND: Human diets account for 30% of greenhouse gas emissions (GHGE). Reporting dietary GHGE with or without energy standardization yields different outcomes, often resulting in conflicting conclusions regarding associations with micronutrient intake.OBJECTIVES: To compare methods of reporting dietary GHGE, with and without consideration of energy intake, and their respective associations wi

How mergers affect galaxy formation depends on both feedback processes, and on the geometry and strength of the mergers themselves. We introduce the PARADIGM project, where we study the response of a simulated Milky-Way-mass galaxy (M200c ∼ 1012 M at z = 0) forming in a cosmological setting to differing merger histories, using genetically modified initial conditions, each simulated with the VINTER

Många människor är idag beroende av matunderstöd från församlingar och kommuner, bland annat på grund av hög inflation och höjda matkostnader. Efterfrågan på hjälp till det nödvändigaste för med sig frågor om värdighet och skam. I forskningsprojektet med namnet Det ovärdiga i att vara hungrig och det ovärdiga i att behöva ta emot mat: Hur kan professionella bidra till värdighet i mötet med hjälpsö

Sammanfattning Uppsatsens titel: Informationshypotesen - Ger förändringar av utdelningar någon information om framtida vinster? Seminariedatum: 2008-02-04 Ämne/Kurs: NEKK01 – Examensarbete kandidatnivå 15hp Författare: Stefan Setterlund Handledare: Erik Norrman Fem nyckelord: The information content of dividends, informationshypotesen, utdelningar, effektiva marknader, vinster. Syfte: Syftet med d

A computer program called IDAC-CAD2VOX has been constructed to create geometry input files from CAD drawings for the Monte Carlo simulation program MCNP. The ICRP reference phantoms are incorporated into the CAD drawings to estimate organ doses and the effective dose. The program is applied to a CAD drawing of a house and a 2D drawing of a radiation protection bunker. The created MCNP geometry was

This contribution explores the attempts by international humanitarian agencies and the post-genocide Rwandan state respectively to deal with exceptionality created by the genocide and return to normality. It does so by comparing two kinds of camps that deal with exceptional life: the refugee camps for Hutu who fled after the genocide and the Rwandan government's ingando re-education camps. While t