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For many patients with von Willebrand disease (VWD), the replacement therapy with von Willebrand factor (VWF)/factor VIII (FVIII) concentrates is the treatment of choice. To evaluate clinical efficacy, safety and tolerability of Wilate, an albumin-free VWF/FVIII concentrate with a ratio of the two haemostatic moieties of approximately 1 to 1, a prospective clinical programme has been designed. The

BACKGROUND: Diagnosis with prostate cancer has been reported to increase the risk of subsequent tumours. However, specific data on individuals with a parental history are not available so far. METHODS: On the basis of the nationwide Swedish Family-Cancer Database including 18,207 primary invasive prostate cancers, standardised incidence ratios (SIRs) were used to estimate the relative risks of sub

Objective. Rosiglitazone (RSG) has been reported to reduce blood pressure (BP) in patients with type-2 diabetes, but similar effects in non-diabetic people with insulin resistance is less clear. Our aim was to test the long-term BP-lowering effects of RSG compared with placebo. Methods. We recruited participants for BP evaluation of RSG treatment from a larger intervention trial. Office BP was rec

The aim of this study was to demonstrate the potential for holographic interferometry to be used for diffusion studies of large molecules in gels. The diffusion and partitioning of BSA (67,000 g/mol) and pullulans (5,900-112,000 g/mol) in agarose gel were investigated. The gel diffusion coefficients obtained for BSA were higher when distilled water was used as a solvent compared to those obtained

Background. We started a large multicenter prospective follow-up study to provide reliable risk estimates of venous thrombosis in families with various thrombophilic defects. Objectives: This paper describes data collected at study entry on venous events experienced before study inclusion, i.e. the baseline data. Patients/methods: All individuals (probands, relatives) registered in nine European t

Objectives: The aim of this study was to establish wild-type MIC distributions of first-line drugs for Mycobacterium tuberculosis, as well as to explore the usefulness of such distributions when setting clinical breakpoints. Methods: We determined the MICs of rifampicin, isonlazid and ethambutol for M. tuberculosis using a Middlebrook 7H10 dilution method for 90 consecutive clinical isolates, 8 re

Glukosamin ingår i glykosaminoglykaner i ledbrosk och synovialvätska. Tidigare gavs glukosamin som kosttillskott, men det klassificeras numera som ett icke-steroidliknande, antiinflammatoriskt läkemedel. Det beror på att flera kliniska studier har visat att glukosamin kan ge symtomlindring hos en del patienter med lätt till måttlig knäartros. Det brukar ta 2 - 4 veckor innan symtomlindringen kan m

Nizar Qabbani (1923-1998) är en av den moderna arabiska poesins främsta förnyare. Han är för närvarande både den mest läste och den mest kontroversielle, den mest älskade och den mest hatade av samtidens poeter i Arabvärlden.

Hexahydrophthalic anhydride (HHPA) and methylhexahydrophthalic anhydride (MHHPA) are highly allergenic compounds used in the chemical industry. The aim of this study was to characterize the protein adducts in erythrocytes following exposure to HHPA and MHHPA. Blood and urine samples were obtained from 51 HHPA- and MHHPA-exposed workers. Erythrocytic proteins from HHPA- and MHHPA-exposed workers we

Rådgivare som utför sitt uppdrag vårdslöst kan bli ersättningsskyldiga inte bara mot uppdragsgivaren utan också mot tredje man. NJA 1987 s 692.

Historically, agriculturally induced CO2 release from soils has contributed to rising levels in the atmosphere. However, by using appropriate management, soils can be turned into carbon sinks. Many of the dryland regions of the world are characterised by degraded soils, a high incidence of poverty and a low capacity to invest in agriculture. Two well-proven soil organic matter models (CENTURY 4.0

Fragility fractures are correlated to reduced bone size and/or reduced volumetric bone density (vBMD). These region-specific deficits may originate from reduced mineral accrual and/or reduced skeletal growth during the first 2 decades of life. Before pathological development can be defined, normal skeletal growth must be described. To evaluate growth of bone size, accrual of bone mineral content (

Nils Månsson Mandelgren levde mellan 1813-1899. Han skaffade sig en konstnärlig utbildning på konstakademierna i Stockholm och Köpenhamn. Genomförde flera forskningsresor i Sverige och dokumenterade allmogekultur, fornminnen samt kyrklig och profan konst och arkitektur. Han deltog bland annat i grundandet av nuvarande Konstfack 1844 och Svensk form året därpå. Mandelgrens forskningsmaterial förvar

Mahmoud Darwish's senaste diktsamlingar är skrivna inifrån Palestina 1997 och 2001, den sista sedan den andra intifadan brutit ut. Vi (Henry Diab & Kerstin Eksell) har förvärvat rättigheterna till dem från författaren. Översättningarna här är hämtade från vårt arbetsmaterial.

Uniquely amongst vitamin K-dependent coagulation proteins, protein C interacts via its Gla domain both with a receptor, the endothelial cell protein C receptor (EPCR), and with phospholipids. We have studied naturally occurring and recombinant protein C Gla domain variants for soluble (s)EPCR binding, cell surface activation to activated protein C (APC) by the thrombin-thrombomodulin complex, and

The aim of the present study was to find clinical parameters affecting incidence and progression of nephropathy in type 2 diabetic patients. A prospective study for 10 years was performed in 385 type 2 diabetic patients (diabetes diagnosis > or =30 years) attending a hospital-based outpatient clinic. Medical risk indicators like diabetes duration, HbA(1c), and blood pressure were related to the de

BACKGROUND: Anal sphincter rupture is a serious complication of vaginal delivery and almost half the affected women have persistent defecatory symptoms despite adequate primary repair. During the past decade, the incidence of anal sphincter ruptures has been increasing in Sweden and is currently estimated to occur in 2.5% of vaginal deliveries. The aim of the study was to report the frequency of a

The incidence of colorectal cancer (CRC) in young patients (≤50 years of age) appears to be increasing. However, their clinicopathological characteristics and survival are controversial. Likewise, the biomarkers are unclear. We used the West China (2008-2013, China), Surveillance, Epidemiology, and End Results program (1973-2011, United States) and Linköping Cancer (1972-2009, Sweden) databases to