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The history of TRP channels and bladder started in the 1980-ies with the studies of Maggi and collaborators, who created the basis for using capsaicin and other vanilloids in LUT disorders. This narrative review gives a brief history of bladder TRP channels, from their discovery, distribution, and function in the bladder to the rationale for and current status of the use of agents acting on them i
This work reports on a method for uncertainty estimation in simulated collider-event predictions. The method is based on a Monte Carlo-veto algorithm, and extends previous work on uncertainty estimates in parton showers by including uncertainty estimates for the Lund string-fragmentation model. This method is advantageous from the perspective of simulation costs: a single ensemble of generated eve
Industrial symbiosis (IS) has been recognized as an important approach to succeed in the transition towards increased circularity in industry and society. IS involves collaboration between different actors sharing resources, aiming to minimize waste, improve resource and/or energy efficiency, resulting in reduced emissions and environmental impact. This study conducts an embedded single case study
Non-genetic variation is the phenotypic variation induced by the differential expression of a genotype in response to varying environmental cues and is broadly categorized into two types: phenotypic plasticity and developmental noise. These aspects of variation have been suggested to play an important role in adaptive evolution. However, the mechanisms by which these two types of non-genetic varia
This paper examines the effect of aid fragmentation on the aid-growth nexus in Sub-Saharan Africa from 1990-2017. Aid fragmentation is measured by both the concentration index (Herfindahl index and ratio of contribution by largest three donors) and donor counts (total number of donors and number of small donors). We find a significant negative effect of aid fragmentation on the effectiveness of ai
Background: Health-related quality of life and patient-related outcome measures for patients with cancer have gained increased interest over the last decade. However, few prospective studies with longitudinal data evaluated health-related quality of life in patients with breast cancer. This study aimed to investigate how health-related quality of life changed from the time of diagnosis to 1 year a
Objectives Increasing epidemiological and experimental evidence suggests that particle exposure is an environmental risk factor for chronic kidney disease (CKD). However, only a few case-control studies have investigated this association in an occupational setting. Hence, our objective was to investigate associations between particle exposure and CKD in a large cohort of Swedish construction worke
Lake–atmosphere carbon exchanges can be significantly affected by photochemical dissolved organic matter (DOM) mineralization. However, our understanding of how increasing allochthonous organic carbon input affects the photoreactivity of DOM per unit of absorbed incoming light is incomplete. Here, we measured the absorption of ultraviolet (UV) light and subsequent photochemical DOM decay in 148 la
This paper presents a sharp interface formulation for modelling diffusional phase transformations. Grain boundary motion is, in accordance with diffusional phase transformation kinetics, determined by the amount of flux towards the interface and is formulated in a level set framework. This approach enables a computational efficiency that can be expected to be higher than what can be achieved with
The Öresund Bridge between Sweden and Denmark was opened in 2000, allowing both road traffic and fast commuter trains to travel between Malmö and Copenhagen. Various agreements have long facilitated passport-free travel. However, at the end of 2015, temporary border controls were first introduced. This paper aims to provide a deeper understanding of portrayals in the news media and everyday mobili
Hållbar mobilitet innebär bland annat att prioritera aktiva färdmedel, närhet och tillgänglighet. Det handlar om mer än minskade utsläpp, det handlar också om att ”sätta människan i centrum”, om att skapa livskraftiga och välmående samhällen för alla, och samtidigt förbättra förutsättningarna för välbefinnande i ett rättvist och jämlikt samhälle, både inom och mellan generationer. Rapporten syftar
The estimation of impulse responses (IRs) is fundamental to various audio applications, including active noise control, telecommunication, and sound zone control. Despite its long history, estimating impulse responses remains challenging when dealing with short signals and with signals having poor spectral excitation. However, in many applications the source is moving such that one has access to s
The spatial impulse response (IR) interpolation problem is of general interest, e.g. for imaging of subsurface structures based on seismic waves, rendering of audio and radar IRs, as well as for numerous spatial audio applications. A commonly used model represents the occurring reflections as equivalent source positions, often being determined using a sparse re-construction framework employing spa
Control of the material microstructure in terms of the grain size is a key component in tailoring material properties of metals and alloys and in creating functionally graded materials. To exert this control, reliable and efficient modeling and simulation of the recrystallization process whereby the grain size evolves is vital. The present contribution is a review paper, summarizing the current st
A cellular automaton algorithm with probabilistic cell switches is employed in the simulation of dynamic discontinuous recrystallization. Recrystallization kinetics are formulated on a microlevel where, once nucleated, new grains grow under the driving pressure available from the competing processes of stored energy minimization and boundary energy reduction. Simulations of the microstructural cha
A measurement of the invisible width of the Z boson using events with jets and missing transverse momentum is presented using 37 fb−1 of 13 TeV proton–proton data collected by the ATLAS detector in 2015 and 2016. The ratio of Z→inv to Z→ℓℓ events, where inv refers to non-detected particles and ℓ is either an electron or a muon, is measured and corrected for detector effects. Events with at least o
Controlling the water level in irrigation channels is important for the efficient management of irrigation and water delivery. In this study, the proportional–integral–derivative (PID) controller was implemented in both the HEC-RAS boundary condition, as an internal model, and MATLAB, as an external model. In the latter, the Hydrologic Engineering Center’s (HEC) River Analysis System (HEC-RAS) mod
Angular correlations between heavy quarks provide a unique probe of the quark-gluon plasma created in ultrarelativistic heavy-ion collisions. Results are presented of a measurement of the azimuthal angle correlations between muons originating from semileptonic decays of heavy quarks produced in 5.02 TeV Formula Presented and Formula Presented collisions at the LHC. The muons are measured with tran
