The expression levels of fetal hemoglobin (HbF) in bacterial recombinant systems are higher compared with normal adult hemoglobin (HbA). However, heme disorientation in globins are often observed in recombinant production processes, both for HbA and HbF, although the degree of heme oriental disorder is much lower for HbF. In addition, the heme disorientation can be converted to a normal conformati

Context: Several studies suggest a link between increased activity of the inflammatory inhibitor-kappaB kinase/nuclear factor-kappaB (IKK/NF-kappaB) pathway in skeletal muscle and insulin resistance. Objective: We aimed to study the regulation of skeletal muscle IKK/NF-kappaB pathway activity as well as the association with glucose metabolism and skeletal muscle insulin signaling. Methods: The stu

Epidemiological studies have shown direct associations between type 2 diabetes and obesity, both conditions associated with hyperglycaemia and hyperinsulinemia, and the risk of pancreatic cancer. Up to 80% of pancreatic cancer patients present with either new-onset type 2 diabetes or impaired glucose tolerance at the time of diagnosis. Recent population studies indicate that the incidence of pancr

Cutaneous human papillomaviruses (HPVs) are a heterogeneous, nonmonophyletic assembly, comprising about 50 characterized types and at least 133 isolates putatively representing new types. Their natural history of infection and potential association with nonmelanoma skin cancer are not well understood. Several PCR systems have been developed that amplify a broad spectrum of cutaneous HPVs. However,

Background: Little is known about the prevalence and incidence of traditional eating disorders (EDs, e.g., anorexia nervosa (AN), bulimia nervosa and binge eating disorder (BED)) in individuals with childhood onset neuropsychiatric disorders, including attention-deficit/ hyperactivity disorder (ADHD) and autism spectrum disorders (ASD). The aim of the present study was to examine the prevalence of

It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1, as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis-regulatory sequences. These associations were dynamic during developmental progression. Occupancy by the

The design of multiple antennas in compact mobile terminals is a significant challenge, due to both practical and fundamental design tradeoffs. In this paper, fundamental antenna design tradeoffs of multiple antenna terminals are presented in the framework of characteristic mode analysis. In particular, interactions between the antenna elements and the characteristic modes and their impact on desi

To make transportation safer, more efficient, and less harmful to the environment, traffic telematics services are currently being intensely investigated and developed. Such services require dependable wireless vehicle-to-infrastructure and vehicle-to-vehicle communications providing robust connectivity at moderate data rates. The development of such dependable vehicular communication systems and

Balland P.-A., Boschma R. and Frenken K. Proximity and innovation: from statics to dynamics, Regional Studies. Despite theoretical and empirical advances, the proximity framework has remained essentially static. A dynamic extension of the proximity framework is proposed that accounts for co-evolutionary dynamics between knowledge networking and proximity. For each proximity dimension, how proximit

A novel polymeric material, off-stoichiometry thiol-ene-epoxy (OSTE+), has been evaluated for the fabrication of neural implants. OSTE+ is easily photo-structurable and exhibits mechanical properties suitable for stable implantation of the probe into brain tissue, while being sufficiently soft at physiological temperatures to reduce living tissue damage. The facile processing of OSTE+ allows use i

Frontotemporal dementia (FTD) is considered to be a mainly early-onset neurodegenerative disorder with a strong hereditary component. The aim of the study was to investigate age-related incidence and family history in FTD compared to other dementia disorders, especially Alzheimer's disease (AD).

The Swedish Arctic Ocean-96 expedition arranged by the Swedish Polar Research Committee took place during 1996 with the Swedish icebreaker M/S Oden. The expedition focused on studying the distribution of radionuclides in different water masses in the central Arctic Ocean. The expedition crossed the Barents Sea, entered the Nansen Basin at the St. Anna Trough, and continued north across the Amundse