Filtyp
Macrophages infiltrate solid tumors and either support survival or induce cancer cell death through phagocytosis or cytotoxicity. To uncover regulators of macrophage cytotoxicity towards cancer cells, we perform two co-culture CRISPR screens using CAR-macrophages targeting different tumor associated antigens. Both identify ATG9A as an important regulator of this cytotoxic activity. In vitro and in
The role of anyonic statistics stands as a cornerstone in the landscape of topological quantum techniques. While recent years have brought forth encouraging and persuasive strides in detecting anyons, a significant facet remains unexplored, especially in view of connecting anyonic physics to quantum information platforms—whether and how entanglement can be generated by anyonic braiding. Here, we d
Purpose: To assess the ability of corneal epithelial aberrations to discriminate forme fruste keratoconus (FFKC) and keratoconus (KC) from normal eyes. Methods: This prospective, case-control study enrolled 91 right eyes from 91 normal participants, 87 eyes with FFKC and 148 eyes with KC. Epithelial aberrations for the 6-mm pupil were measured using an anterior segment optical coherence tomography
Objective: The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines for thecare of patients with diseases of the mesenteric and renal arteries and veins, in succession to the first 2017guidelines, with the aim of assisting physicians and patients in selecting the best management strategy.Methods: These guidelines are based on scientific evidence and expert opinio
BACKGROUND: Reliable biomarkers for amyotrophic lateral sclerosis (ALS) are urgently needed due to diagnostic and prognostic challenges. This systematic review and meta-analysis aimed to synthesize recent evidence on the utility of blood and cerebrospinal fluid (CSF) biomarkers for ALS.METHODS: We systematically reviewed studies published from January 1, 2019 to March 25, 2025, that evaluated bloo
There has been a growing interest in how workers in high-carbon industries are impacted by low-carbon transitions and how such transitions can be implemented in a way that is just. This study explores the socio-cultural dimensions of these processes, focusing on the role of identity in shaping workers’ perceptions of low-carbon transitions and their ability to navigate change. It does so through a
Book Review: Waqas H Butt. Life Beyond Waste. Work and Infrastructure in Urban Pakistan. [South Asia in Motion.] Stanford University Press, Stanford (CA) 2023. xx, 225 pp. Ill. Maps. $90.00. (Paper. E-book: $28.00.)
The international humanitarian system has, since the 19th century, been activated during large-scale disasters when the capacities of the affected countries are overwhelmed. It comprises international humanitarian organizations (IHOs) and is funded by a variety of donors. Recently, this system has faced increasing criticism, mainly because of its failure to empower and include local and national a
Birds migrate across the globe on their wings, a behavioural adaptation that allows birds to exploit seasonal environments. Their migrations are ultimately influenced by their ability to fly, a costly but high energy-efficient mode of locomotion that enables birds to travel far distances in a short amount of time. This thesis investigates bird migration from a flight energetic perspective, focusin
Conventional diagnostic methods often involve long incubation times due to limited fluid mixing in confined spaces, despite offering high sensitivity. Therefore, acoustic streaming was employed to enhance microscale advection, thereby improving biomolecular interactions and reducing assay duration. The micromixing capability was demonstrated by dispersing methylene blue (MB) in deionized water and
Background: Evidence is limited on whether alterations in diabetes-related health parameters are detectable before clinical diagnosis in novel diabetes subtypes. We investigated trajectories of diabetes-related health parameters in individuals with recently diagnosed type 2 diabetes (T2D). Methods: Using data from the Stockholm Diabetes Prevention Programme cohort (SDPP) participants (n = 215) wit
Background: The COVID-19 pandemic accelerated the use of telemedicine, specifically video consultations as they provide healthcare access in challenging situations where face-to-face encounters are not possible. Nevertheless, it remains largely unknown to what extent the organisation of general practice and national digital infrastructures have impacted the uptake and use of video consultations. O
Pathogenic bacterial infections lead to bacterial resistance and biofilm formation, causing significant suffering and presenting an urgent issue to be addressed. Polymer materials have garnered considerable attention in the antibacterial field due to their functional moldability and molecular structure designability. These materials can achieve various antibacterial functions by regulating their m
Background: The ability of modern ultrasound machines to detect signs of enthesitis has increased, yet there is a lack of studies on patients with long-standing radiographic axial spondyloarthritis (r-axSpA). Hence, we aimed to investigate the prevalence and clinical significance of Doppler signals indicative of inflammation in peripheral entheses of patients with long-standing disease. Methods: P
Objective: Primary care is the base in many health care systems, and to identify the most registered diagnoses in primary care is a way to identify the overall health care use and needs in society. We estimated the rates of the 30 most common diagnoses in primary health care and their male to female ratio. Research design and methods: This was a study including inhabitants 18 years and older out o
Mutations causing Parkinson’s disease (PD) give diverse pathological phenotypes whose cellular correlates remain to be determined. Those with PRKN mutations have significantly earlier selective vulnerability of dopamine neurons, those with SNCA mutations have increased alpha-synuclein deposition, while those with LRRK2 mutations have additional deposition of tau. Yet all three mutation types are i
Water resource recovery facilities face challenges with increasingly stringent effluent demands, complexity and demand for capacity increasing investments. Emerging technologies such as digital twins could alleviate these problems but require high frequency influent data. This work presents a method for utilising measurements in the primary clarifier effluent with a model of the processes between
Concertos for bass tuba from the mid-nineteenth century, recorded between January - July 2025 using a copy of a Moritz-Wieprecht bass tuba, the original tuba patented in Berlin in 1835.
Sweden’s art and music schools (SAMS), established in the 1940s, provideaffordable extra-curricular instrumental and singing teaching for everychild, regardless of their family’s financial situation. Tuition is heavilysubsidised, with families contributing only some 7% of the cost. WhileSAMS traditionally offer one-to-one instruction, a recent governmentalreport (2016) advocates for group teaching
Recent years has seen increasing interest in the concept of affordances in music performance research. Hereby, the agency of musical instruments is understood as defined by the perceived opportunities for action emerging through the sensorimotor relationship (i.e. the continuous interaction between musician and instrument). As such, it is an analytical perspective that highlights material and embo
