Trisomy 8 (+8) is a common cytogenetic aberration in acute myeloid leukemia (AML); however, the impact of +8 in pediatric AML is largely unknown. We retrospectively investigated 609 patients from the NOPHO-AML database to determine the clinical and cytogenetic characteristics of +8 in pediatric AML and to investigate its prognostic impact. Complete cytogenetic data were available in 596 patients (

Human body has the natural ability to protect and heal itself, like all the systems which existing in the nature. It means that, Immune System which is one of the main systems in humans that protects them from illness. In other words, it is a network of cells, tissues, and organs designed complexly for preventing the body against germs, viruses, and other form of body toxins. Asmicrobial invasions

We report the discovery of a thermodynamically stable line hexatic (N + 6) phase in a three-dimensional (3D) system made up of self-assembled polymer-like micelles of amphiphilic molecules. The experimentally observed phase transition sequence nematic (N)⇌N + 6⇌two-dimensional hexagonal (2D-H) is in good agreement with the theoretical predictions. Further, the present study also brings to light th

Electronic devices based on graphene technology are catching on rapidly and the ability to engineer graphene properties at the nanoscale is becoming, more than ever, indispensable. Here, we present a procedure of graphene functionalization on SiC(0001) that paves the way towards the fabrication of complex graphene electronic chips. The procedure resides on the well-known ion-implantation technique

Background & purpose Infants on chronic peritoneal dialysis (PD) have an increased risk of developing neurological morbidities; however, the underlying biological mechanisms are poorly understood. In this clinical study, we investigated whether PD-mediated impairment of nitric oxide (NO) bioavailability and signaling, in patients with persistently low systolic blood pressure (SBP), can explain

Artikeln behandlar utrymmet för förvaltningsorgan under regeringsnivånatt på egen hand anta bindande regler enligt svensk rätt. Grundlagsregleringenger stort utrymme för delegation till förvaltningen, somenligt den svenska konstitutionella strukturen har en betydande självständighet.Det finns dock principiella invändningar mot att förvaltningen ska kunna anta föreskrifter med samma bindande verkanThe Article deals with the scope for Swedish administrative agencies to adopt binding rules under the 1974 Instrument of Government.

Gasification processes convert carbon-containing material into syngas through chemical reactions in the presence of gasifying agents such as air, oxygen, and steam. Syngas mixtures produced from such processes consist mainly of carbon monoxide (CO), hydrogen (H2), carbon dioxide (CO2), and methane (CH4); this gas can be directly utilised as a fuel to produce electricity or steam. Besides, it is re

BACKGROUND: There are conflicting reports on the effect of donor-recipient HLA matching on outcomes in heart transplantation. The objective of this study was to investigate the effects of HLA-A matching relative to HLA-B and -DR matching on long-term survival in heart transplantation.METHODS: A total of 25 583 patients transplanted between 1988 and 2011 were identified from the International Socie

PURPOSE: Renal cell carcinoma (RCC) is derived from a tissue with a remarkable capacity for vectorial transport. We therefore performed an unbiased exploration of transporter proteins in normal kidney and kidney cancer in order to discover novel clinical targets.EXPERIMENTAL DESIGN: Using the TCGA database we investigated differences in membrane transporter expression in ccRCC and normal kidney. W

Growing interests have been devoted to the design of polymer acceptors as potential replacement for fullerene derivatives for high-performance all polymer solar cells (all-PSCs). One key factor that is limiting the efficiency of all-PSCs is the low fill factor (FF) (normally

Density dependent growth and optical properties of periodic arrays of GaAs nanowires (NWs) by fast selective area growth MOVPE are investigated. As the period of the arrays is decreased from 500 nm down to 100 nm, a volume growth enhancement by a factor of up to four compared with the growth of a planar layer is observed. This increase is explained as resulting from increased collection of precurs

Background: Chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cell (CRTh2) receptor antagonists is being investigated for asthma. Objectives: The aim of this study was to assess the effects of the CRTh2 receptor antagonist, AZD1981 (with/without inhaled corticosteroids [ICSs]), on lung function and asthma control. Patients and methods: Adults aged 18–60 years were enr

We address H-infinity state feedback and give a simple form for an optimal control law applicable to linear time invariant systems with symmetric and Hurwitz state matrix. More specifically, the control law as well as the minimal value of the norm can be expressed in the matrices of the system's state space representation, given separate cost on state and control input. Thus, the control law is tr

Among truthmaker theorists it is generally thought that we are not able to use the entailment principle (i.e. the principle according to which truthmaking distributes across entailment) to ground negative truths. But these theorists usually only discuss truthmakers for truth-functional complexes, thereby overlooking the fact that there are non-truth-functional complexes whose truth values are not

In this article, we briefly identify three main challenges/issues that should be taken into consideration in the institutionalization of entrepreneurship research: (1) recognizing the complexity of the phenomenon under study; (2) producing interesting, relevant and useful research results for all stakeholders; and (3) developing a critical posture in research. Following the discussion of these cha

This book synthesizes 30 years of research on business angels by charting the significant role they play in the financing of entrepreneurial businesses in both developed and emerging economies. The expert group of contributors examine business angels themselves, the evolution of the market and the role of public policy in influencing angel investment. Finally, the editors provide an agenda for fut

In the chapter the authors revisit one of the original topics in business angel research: to measure the scope of the business angel market and evaluate its impact on the economy, especially the financial contributions of business angels at the macro (market) level. This is an issue that has considerable policy relevance. Most policy initiatives to support business angel activities have been intro