BACKGROUND: The melanoma-specific survival (MSS) is heterogenous between stages and is highly dependent on the T stage for primary localized disease. New systemic therapies for metastatic cutaneous melanoma (CM) have been introduced since 2012 in Sweden.OBJECTIVES: To analyse the incidence and MSS time trends between 1990 and 2020 in Sweden.METHODS: Nationwide, population-based, and prospectively

An emissions barrier was installed in a building where a wall had been treated with a tar-containing material as an impregnation agent and moisture barrier. There was a strong disturbing smell inside the building. Several polycyclic aromatic hydrocarbons (PAH) were identified in the indoor air amounting to a total of 1726 ng PAH/m3. The amounts decreased to 139 ng/m3 after the barrier had been ins

Degenerative meniscus lesions have been associated with both osteoarthritis etiology and its progression. We, therefore, sought to establish a human meniscus ex vivo model to study the meniscal response to cytokine treatment using a proteomics approach. Lateral menisci were obtained from five knee-healthy donors. The meniscal body was cut into vertical slices and further divided into an inner (ava

Many deltas are increasingly threatened by environmental change, including climate change-induced sea-level rise, land subsidence and reduced sediment delivery. Dealing with these challenges is a pressing necessity because deltas are home to many people and are important centres for economic and agricultural development. Successfully adapting to climate change requires a social-ecological system (

An emissions barrier consisting of a cloth with a hydrophilic polymer layer and an adsorbent layer was found to be efficient in stopping radon emissions from radium-containing aerated concrete. Laboratory studies revealed a radon permeability of k= 3.958 x 10-11 m2/s. Applying the cloth indoors in an apartment, on the floor and three walls made up from aerated concrete, resulted in a decrease in i

Objectives: In this study, we apply a clustering method to proteomic data sets from bovine and human models of post-traumatic osteoarthritis (PTOA) to distinguish clusters of proteins based on their kinetics of release from cartilage and examined these groups for PTOA biomarker candidates. We then quantified the effects of dexamethasone (Dex) on the kinetics of release of the cartilage media prote

Saving peak powers in the heating systems have been in focus for some years now. Sweden has more and more cooling systems with an increase in cooling also in residential buildings. The cooling power is much more expensive than the heating power and the cost of cooling is largely driven by installed power. Therefore, there is a relative advantage of reducing the cooling power instead of heating pow

Objectives: There is an unmet medical need for biomarkers in OA which can be applied in clinical drug development trials. The present study describes the development of a specific and robust assay measuring type II collagen degradation (T2CM) and discusses its potential as a noninvasive translational biomarker. Methods: A type II collagen specific neoepitope (T2CM) was identified by mass spectrome

Primary care in several countries is developing towards team-based and multi-professional care, requiring leadership and management capabilities at the primary care practice level. This article reports findings from a study of primary care managers in Sweden, focusing variation in performance and perceptions of feedback messages and goal-clarity, depending on managers’ professional background.

We explore how a management control initiative travels across and is translated within organizations—from the decision motives for adoption or rejection to the subsequent decision motives for sustaining or abandoning the control—through the lens of diffusion theory. Our empirical case is the journey of activity-based funding of hospitals across 21 Swedish healthcare authorities. We develop a frame

Policy-makers are starting to acknowledge the urgent need for policy-intervention to achieve sustainable consumption. However, it is difficult to achieve policy-making that leads to impactful consumption interventions. Generally speaking, sustainable consumption can be achieved in three ways; to reduce consumption, to change consumption, and to improve consumption. These strategies all have their

Flavonoid compounds like anthocyanins and proanthocyanidins are important plant secondary metabolites having wide biological activities for humans. In this study, the molecular function of the Ant13 locus, which is one of the key loci governing flavonoid synthesis in barley, was determined. It was found that Ant13 encodes a WD40-type regulatory protein, which is required for transcriptional activa

We present a genome assembly from an individual female Fabriciana adippe (the high brown fritillary; Arthropoda; Insecta; Lepidoptera; Nymphalidae). The genome sequence is 485 megabases in span. Most of the assembly (99.98%) is scaffolded into 29 chromosomal pseudomolecules with the Z sex chromosome assembled. The complete mitochondrial genome was also assembled and is 15.1 kilobases in length. Ge

It has been proposed that the relatively low duty cycle of the European Spallation Source (ESS) linac allows acceleration of additional mathbfH^- ion pulses interleaved with the baseline proton pulses, representing a unique opportunity to construct a neutrino super beam (ESSnuSB) facility of unparalleled luminosity. Coupled with a distant Cherenkov detector, it is believed that evidence of CP viol

This book discusses the organ-specific systemic manifestations of COVID-19. The initial chapters of the book review the origin and evolution of the coronaviruses, followed by pathogenesis and immune response during COVID-19 infection. The book also provides insight into the role of angiotensin-converting enzyme 2 in the onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen