BACKGROUND: The adhesive mechanisms regulating leucocyte-endothelium interactions in the pancreas remain elusive, but selectins may play a role. This study examined the molecular mechanisms mediating leucocyte rolling along the endothelium in the pancreas and the therapeutic potential of targeting the rolling adhesive interaction in acute pancreatitis (AP). METHODS: Pancreatitis was induced by ret

Haemophilia care has undergone substantial improvements during the past 40-50 years. Early clotting factor concentrates were not sufficiently refined to enable self-administered treatment at home until the 1970s. Unfortunately, these advances led to transmission of viral diseases including HIV and hepatitis, resulting in an increased burden of morbidity and mortality, especially during the 1980s.

BACKGROUND: Abnormal cerebrospinal fluid (CSF) biomarker levels predict development of Alzheimer disease with good accuracy and are thought to precede cognitive deterioration. OBJECTIVE: To investigate whether changes in CSF biomarker levels over time in healthy older adults are associated with a concurrent decline in cognitive performance. DESIGN: Retrospective analysis of longitudinal CSF biomar

Intra-domain routing in IP networks is based on the shortest path principle by assigning administrative weights (costs) to links. The resulting least-cost paths determine routes between pairs of routers. If several such equal-cost paths exist between a pair of routers, it may not be clear which of them is actually used to route traffic. This makes it difficult to predict the network traffic flow d

An experimental study of interaction in a collaborative desktop virtual environment is described. The aim of the experiment was to investigate if added haptic force feedback in such an environment affects perceived virtual presence, perceived social presence, perceived task performance, and task performance. A between-group design was employed, where seven pairs of subjects used an interface with

The delineation and characterization of fracturing is important in the successful exploitation of many hydrocarbon reservoirs. Such fracturing often occurs in preferentially aligned sets; if the fractures are of subseismic scale, this may result in seismic anisotropy. Thus, measurements of anisotropy from seismic data may be used to delineate fracture patterns and investigate their properties. Her

Abstract in German Die Lektüre von Still Songs eröffnet einen neuen, interessanten und zugleich kritischen Blick auf Celans „MusikGedichte“ und deren Vertonungen und auf die Celan-Forschung überhaupt. Passagen zur Detailebene einzelner Gedichte – wie Todesfuge, Schlaflied, Saitenspiel, Engführung oder Fadensonnen – und deren Vertonungen – durch Tilo Medek, Erhard Karkoschka, Harrison Birtwistle, A

Social visions to replace fossil fuels with renewable energy sources have motivated unprecedented growth in global renewable energy manufacturing. Previous literature shows that people committed to realizing such visions have difficulties reconciling with the negative social-ecological impacts of this mass production even if it presents a formidable challenge to a socially just and ecologically su

This article reviews some of the communicative strategies of plant-based meat, a food innovation that promises an experience akin to that of animal meat, but devoid from its harmful consequences relating to the well-being of humans, animals, and the planet. Mobilizing a constitutive approach on communication, we trace the founding narrative of the Beyond Meat firm using various documents, which en

Coal power phase-out is critical for climate mitigation, yet it harms workers, companies, and coal-dependent regions. We find that more than half of countries that pledge coal phase-out have "just transition" policies which compensate these actors. Compensation is larger in countries with more ambitious coal phase-out pledges and most commonly directed to national and regional governments or compa

The spatial imprint of forest disturbances, which can result from a variety of anthropogenic and natural causes, is important in shaping the form and function of the world’s forests. However, we lack a systematic assessment of how the forms of forest disturbances differ globally, which could help in sustainable forest policy and management initiatives to protect forest biomes. Here we produce a gl

Tree growth and longevity trade-offs fundamentally shape the terrestrial carbon balance. Yet, we lack a unified understanding of how such trade-offs vary across the world's forests. By mapping life history traits for a wide range of species across the Americas, we reveal considerable variation in life expectancies from 10 centimeters in diameter (ranging from 1.3 to 3195 years) and show that the p

This study addressed the interaction between short-term adaptation to apneas with face immersion and erythrocyte release from the spleen. Twenty healthy volunteers, including ten splenectomized subjects, participated. After prone rest, they performed five maximal-duration apneas with face immersion in 10 degrees C water, with 2-min intervals. Cardiorespiratory parameters and venous blood samples w