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Flame soot characterization using combined multi-wavelength thermo-optical analysis and Raman spectroscopy

Multi-wavelength thermo-optical analysis (MW-TOA) and Raman spectroscopy are commonly used methods to study soot sampled on filters, in terms of carbon content, nanostructure, and absorption properties. In this work, these techniques were combined to study how these characteristic properties of soot change in premixed flames, 1) at various flame heights during soot maturation and 2) as a result of

Movement texts : materiality, social practice, and discursive genre

This article aims to conceptualize movement texts as a crucial yet often overlooked phenomenon in the articulation of collective identity and narratives in the context of social movements. We define movement texts as symbolic acts that publicly manifest a social movement as a collective actor. Against the backdrop of the “narrative turn” in social movement studies and adjacent fields, we argue tha

Cognitive mechanisms in simile and metaphor comprehension

This study investigates whether metaphors and similes are processed the same way or not. Comparison accounts of metaphor claim that metaphors and similes use the same cognitive mechanisms because metaphors are implicit similes, while Categorization accounts claim that the two figures of speech require different cognitive mechanisms. It is unclear which position has the most support. We address thi

The fibroblast epigenome underlies SS18::SSX-mediated transformation in synovial sarcoma

Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy that is characterised by a pathognomonic t(X;18)(p11.2;q11.2) translocation, which produces the fusion oncogene named SS18::SSX. Despite recent advancements in our understanding of synovial sarcoma biology, the cell-of-origin remains undefined. A mesenchymal stromal cell (MSC) specific CreERT2 line was employed to express SS18::SSX in

Advances in the clinical management of parathyroid disorders : report from the 2024 workshop by the ESE educational program on parathyroid disorders

The present report from the ESE Educational Program on Parathyroid Disorders (PARAT Program) presents recent developments and novelties in the clinical care of parathyroid disorders in a question-and-answer format, based on a satellite workshop held in relation to the European Congress of Endocrinology in Stockholm, May 2024. The workshop focused on clinical aspects of 3 main themes: primary hyper

Pathological response to pembrolizumab-based neoadjuvant therapy in ER-low vs. ER-zero breast cancer : a Swedish population-based cohort study

Background: Emerging evidence indicates that estrogen receptor-low (ER-low)/human epidermal growth factor receptor 2 negative (HER2-) breast cancer (BC) may more closely resemble ER-negative (ER-zero, < 1%) rather than ER-positive disease in terms of biological and clinicopathological characteristics. In Sweden, ER-low (ER 1–9%) BC is managed as triple-negative breast cancer (TNBC) and is thus eli

Locus coeruleus-entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein

INTRODUCTION: Pretangle tau inclusions from the locus coeruleus (LC) are hypothesized to propagate to the entorhinal cortex (EC) via neuron-to-neuron transmission along its projections. The lower integrity of the LC-EC pathway accompanying Alzheimer's disease (AD) pathology is supported by post mortem studies, but in vivo evidence remains limited. METHODS: We associated diffusion-weighted 7T magne

Microbial associations and viruses on the risk of celiac disease (MAVRiC) : a longitudinal post-hoc case-cohort study

Celiac disease etiopathogenesis requires genetic predisposition and exposure to gluten, yet these factors alone are not sufficient. Larger longitudinal studies are needed to determine the role of time-varying infections and gut microorganisms. The aim was to design a celiac disease case-cohort longitudinal study using The Environmental Determinants of Diabetes in the Young (TEDDY) study. By age 3-

Second Primary Lung Cancer Associated With Family History of Lung Cancer

Background: Familial clustering of initial primary lung cancer (IPLC) may be related to shared smoking habits, other environmental exposures and hereditary factors, but whether familial risk also influences the risk of second primary LC (SPLC) is not well known. We aimed to carry out a family study between first-degree relatives on SPLCs in Sweden. Methods: Population data on Swedish family relati

Fact-checkers Perception on Social Media Governance Models to Combat Disinformation : Insights from a European Qualitative Study

Disinformation is growing rapidly on social media, driven by evolving tactics. Meanwhile, the shift towards community-based fact-checking has raised concerns among fact-checking organizations. This study aims to explore fact-checkers’ perceptions of changes in social media governance models to counter disinformation. Based on qualitative interviews with European fact-checkers, the study reveals th

Interstellar ices as carriers of supernova material to the early solar system

Planetary materials show systematic variations in their nucleosynthetic isotope compositions that resonate with orbital distance. The origin of this pattern remains debated, limiting how these isotopic signatures can be used to trace the precursors of terrestrial planets. Here we test the hypothesis that interstellar ices carried supernova-produced nuclides by searching for a supernova nucleosynth

A Review of the Spatiotemporal Evolution of the High Arctic Large Igneous Province, and a New U-Pb Age of a Mafic Sill Complex on Svalbard

The High Arctic Large Igneous Province (HALIP) formed in the circum-Arctic during the Cretaceous. The timing and duration of emplacement of these mafic magmas are important for understanding the climatic and environmental effects, yet many uncertainties remain. The dating methods used vary greatly between different regions. For example, the mafic intrusions in Svalbard have mainly been dated using

DOGMA : de novo assembly of densely labelled optical DNA maps using a matrix profile approach

In optical genome mapping (OGM), large numbers of individual DNA maps—sequence-specific data series along single DNA molecules—are produced. Such individual maps have to be stitched together in a process called de novo OGM assembly in order to create consensus OGM maps for corresponding regions along the chromosomes. While there are several types of experimental OGM assays, not all of them have de

Associations Between Hiccups and Subsequent Cancer Diagnoses : A Population-Based Cohort Study

Background: Several case reports have recounted hiccups as a possible symptom of cancer, but potential associations in large study samples have not been examined. Methods: This population-based cohort study examined associations between hiccups and subsequent cancer diagnoses. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated. Results: Of 8466 patients diagnos

Complex genotype-phenotype relationships shape the response to treatment of down syndrome childhood acute lymphoblastic leukaemia

Extensive genetic and epigenetic variegation has been demonstrated in many malignancies. Importantly, their interplay has the potential to contribute to disease progression and treatment resistance. To shed light on the complex relationships between these different sources of intra-tumour heterogeneity, we explored their relative contributions to the evolutionary dynamics of Acute Lymphoblastic Le

Exit, voice and loyalty in everyday home care practice for older adults : Using a telephone diary method

Older adults are often portrayed as unwilling or unable to address quality issues in the formal care they receive. This study explores a methodology that captures the everyday reactions of older care users to quality problems, offering a nuanced understanding of their voice and agency when dissatisfied with care services. Using a telephone diary method, eight care users were contacted twice a week

A missed diagnosis of acute aortic syndrome is associated with ischaemic ECG changes and an initial suspicion of myocardial infarction : a retrospective observational study

Background: Acute aortic syndrome (AAS) is a life-threatening condition reported as often misdiagnosed. Advancements in CT availability and diagnostic algorithms, including high-sensitivity troponin and D-dimer for acute coronary syndrome (ACS) and pulmonary embolism (PE), may reduce AAS misdiagnosis, but the impact remains unclear. This study evaluated the incidence, characteristics, and clinical

Resting-state hippocampal asymmetry as a marker for memory and olfactory deficit in parkinson’s disease

Memory decline is a central cognitive symptom in Parkinson’s Disease (PD). While task-fMRI studies link hippocampal activity (AHA) to poorer memory and olfactory performance, this relationship during rest remains understudied. The objectives of this study are to examine differences in resting-state hippocampal networks, explore the occurrence of reduced AHA within these networks, and investigate i

A non-affinity-dependent high-resolution mass spectrometry method for detecting and typing monoclonal free light immunoglobulin chains

Background: Detecting and monitoring monoclonal free light immunoglobulin chains in serum is important for managing patients with B-cell neoplasms. Established methods have relied on immunochemistry, with monoclonality determined through an abnormal ratio of free kappa and lambda chains and an increased concentration of the involved chain. This indirect approach has limitations. Mass spectrometric