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Background – While amyloid-β (Aβ) and tau are hallmark pathologies of Alzheimer’s disease (AD), TDP-43 proteinopathy is increasingly recognized as an important contributor, occurring in up to 57% of AD cases and associated with accelerated cognitive decline. TDP-43 regulates RNA splicing, and its mislocalization leads to cryptic exon inclusion and loss of canonical protein function. While neuronal
Forest above-ground biomass (AGB) estimation is crucial for evaluating carbon dynamics. Although optical and synthetic aperture radar (SAR) data provide complementary spectral and structural information, limitations in existing fusion approaches restrict AGB estimation accuracy. This study proposes a multi-source data fusion framework comparing two image fusion strategies—the conventional Hue-Inte
Generative AI promises substantial productivity gains, but many initiatives fail. This column argues that outcomes depend on readiness, not technology alone. We examine AI transformation requirements across organizational, individual, and technological dimensions, highlighting why engineering practices, human factors, and strategic clarity determine success.
Preeclampsia (PE) is a complication during pregnancy characterized by hypertension, organ damage, and systemic inflammation. Increasing evidence suggests that the gut microbiome may play a role in the pathophysiology of PE. However, previous studies on the gut microbiome have generally overlooked the distinction between subgroups of PE, although clinical manifestations may differ. Also, most studi
p27, a cyclin-dependent kinase inhibitor, functions as a tumour suppressor in the nucleus but may acquire oncogenic properties when mislocalized to the cytoplasm. While KRAS mutations can induce p27 phosphorylation and cytoplasmic retention, the regulation and significance of p27 expression in wild-type (WT) KRAS colorectal cancer (CRC) remain unclear. This study investigated the relationship betw
Low- and middle-income countries are expanding health insurance to enhance financial protection. However, there is scarcity of evidence on the stakeholder perceptions towards health insurance. This study explores stakeholders' perceptions towards the implementation of the National Health Insurance Scheme in Zambia. This qualitative study is based on 21 in-depth interviews with key stakeholders inv
BACKGROUND: Improving utilization of contraceptive methods serves as a powerful catalyst for advancing women's education, health, and personal autonomy. Many countries have pledged to enhance contraceptive availability as part of their commitment to the Sustainable Development Goals (SDGs), specifically under indicator 3.7.1. This study sought to understand the drivers of modern contraceptive use
Sexual harassment persists in academic workplaces despite extensive policy frameworks. This study explored how employees at a large Swedish university perceive and articulate the organisational culture and everyday norms that shape sexual harassment. Ten focus group discussions were held with forty staff members, separated by managerial role and conducted in Swedish or English. Transcripts were an
Two protein ingredients, vital wheat gluten (WG) and hempseed protein concentrate (HPC), were extruded both individually and in combination, in a co-rotating twin-screw extruder to produce pilot-scale high-moisture meat analogues. To determine possible textural outcomes, the impact of the ratio between the input materials and operational settings was investigated. Seven different WG and HPC ratios
Abstract in French:Au cours des dernières décennies, les études alévies se sont affirmées comme un champ interdisciplinaire, à la croisée de l’histoire, de l’anthropologie, de la sociologie, des sciences politiques et des sciences des religions. Si cette consolidation institutionnelle et académique représente une avancée majeure, certains aspects clés de l’histoire alévie restent sujets à débat, eOver recent decades, Alevi Studies has emerged as an interdisciplinary field drawing on history, anthropology, sociology, political science, and religious studies. While this institutional and scholarly consolidation marks significant progress, key aspects of Alevi history remain contested, particularly interpretations shaped by early 20th-century nation-building paradigms. Dominant binaries such
Abstract in French:Cette introduction situe le numéro spécial Passés Alévis contestés dans les efforts en cours visant à repenser la tradition alévie, en mettant au premier plan la pluralité, le dynamisme et le caractère situé des imaginaires liés à l’histoire des Alévis. Cette introduction soutient que les cadres épistémologiques façonnés par des paradigmes orientalistes et nationalistes, ainsi qThis introduction positions the special issue Alevi Pasts Contested as an intervention in the ongoing effort to rethink Alevi tradition by foregrounding the plurality, dynamism, and situated character of imaginations related to the history of the Alevis. It argues that epistemological frameworks shaped by Orientalist and nationalist paradigms, as well as ethnographic and diaspora research, have pr
This article analyses how experiences of state-sanctioned violence in Turkey are shaped, conveyed and renegotiated in Alevi life stories. Drawing on personal accounts, it exami-nes how individual experiences of violence are interwoven with collective narratives of persecution, marginalisation and resistance. The study focuses in particular on two in-terviewees, Berfin and Ahmet, whose stories illu
Offshore wind farms (OWFs) pose a potential threat to migratory birds, either as a barrier or as a result of lethal collisions. We aimed to demonstrate the temporal and spatial frames for potential mitigation measures for a rare and protected species. We analysed 74 autumn migration tracks for 65 GPS-tagged Caspian terns (Hydroprogne caspia) through an area with operating and planned OWFs. On thei
In this study, soil cores (0–20 cm) were collected at 45 sites located within a 30-km radius zone around the Belarusian nuclear power plant (BelNPP) in 2019 before its commissioning. Activity of gamma-emitting radionuclides was measured in the samples using HPGe detectors. The study revealed low levels of 137Cs in the soil: the weighted average dry weight (d.w.) activity concentration (ACw) varied
We characterized patients with discordant plasma p-tau217 results and amyloid status determined by the Aβ42/p-tau181 CSF ratio or Aβ-PET biomarkers in an ethnically diverse mixed memory clinic cohort. Among 539 patients, 83.9% had concordant biomarker profiles, while 13.4% were amyloid negative and plasma p-tau217 positive discordant, and 2.8% were amyloid positive and plasma p-tau217 negative dis
Background: The use of patient-reported outcome measures (PROM) can be beneficial in several ways. However, presentations of PROM data from individuals living with, through, or beyond cancer are scarce in the existing scientific literature, and challenges in presenting and interpreting PROM data may be an explanation. Our overall aim was to describe aspects of wellbeing in individuals living with
The paper explores how Indigenous, Black, and Campesinas women in the Colombian Caribbeantransform everyday practices of care into socio-environmental leadership and territorial defence.Based on oral histories collected through collaborative research on water governance and climatechange, we examine how emotions and ecological knowledge converge in defending land, water, andcollective well-being.
OBJECTIVE: Avacopan (AVAC), an oral selective C5a receptor inhibitor, has been approved for treatment in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Outside randomized controlled studies, real-world data are scarce. The aim of this study was to provide further insight into the clinical experience of AVAC.METHOD: We analysed data from 16 patients with severe AAV include
