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Sanfilippo syndrome type C (mucopolysaccharidosis IIIC) is an early-onset neurodegenerative lysosomal storage disorder, which is currently untreatable. The vast majority of studies focusing on disease mechanisms of Sanfilippo syndrome were performed on non-neural cells or mouse models, which present obvious limitations. Induced pluripotent stem cells (iPSCs) are an efficient way to model human dis
This study looks at the effect of losing a parent before the age of 16 on adult income, educational attainment, and health. Using detailed data from the Swedish registers and several methodological strategies, we follow to adulthood individuals born between 1968 and 1981 and observe their later-life outcomes.The results suggest that, in line with previous research, losing a parent during childhood
Context. Positions and proper motions of Gaia sources are expressed in a reference frame that ideally should be non-rotating relative to distant extragalactic objects, coincident with the International Celestial Reference System (ICRS), and consistent across all magnitudes. For sources fainter than 16th magnitude, this is achieved through Gaia's direct observations of quasars. At brighter magnitud
The high rate of disability pensioners is alarming in many industrial countries today. In Sweden the rate was 9.5% of the population aged 16-54 years in March 2005. Through new legislation, which came into force 2000, disability pensioners in Sweden are able to go back to work without jeopardising their benefit. This 'resting disability pension' was used by 0.2% of all disability pensioners in SweThe high rate of disability pensioners is alarming in many industrial countries today. In Sweden the rate was 9.5% of the population aged 16-54 years in March 2005. Through new legislation, which came into force 2000, disability pensioners in Sweden are able to go back to work without jeopardising their benefit. This 'resting disability pension' was used by 0.2% of all disability pensioners in Swe
Estimating age distributions, or star formation histories, of stellar populations in the Milky Way is important in order to study the evolution of trends in elemental abundances and kinematics. We build on previous work to develop an algorithm for estimating the age-metallicity distribution which uses the full age-metallicity probability density functions (PDFs) of individual stars. No assumptions
Närsjukvård är ett centralt begrepp i ett förändringsarbete som för genomförs i nordöstra Skåne för att utveckla hälso- och sjukvårdsväsendet. Det ingår därmed som en av de centrala delarna av Region Skånes vision om hälso- och sjukvård: Skånsk livskraft – vård och hälsa. Syftet med denna rapport är att ge en bakgrund till begreppet (Del A) och att presentera en del preliminära rön beträffande hur
The dynamic response of blocks sitting on a half-space is considered. Buildings and other structures placed on or within the ground influence the transmission of seismic waves. Hence, the presence of a building will have an impact on the dynamic response of neighbouring buildings. Furthermore, obstacles such as concrete blocks lead to wave scattering that may be beneficial or unfavourable for the
Frequent language exposure and use are among the most important conditions for successful language learning whether in classrooms, during study abroad, or in other informal contexts. Research probing exposure and usage often relies on one-off self-report questionnaires in which participants estimate their typical level of language exposure over extended periods of time, often long after it occurre
I Att motverka skatteflykt undersöks de rättsliga avvägningar och följande gränsdragningsfrågor som åtföljer införandet av generella åtgärder mot skatteflykt. Studien motiveras av den harmonisering som under senare år skett inom unionsrätten, där antagandet av skatteflyktsdirektivets missbruksregel inneburit en betydande tillnärmning på företagsskatteområdet. Genom att studera och jämföra införlivThis doctoral disseration examines how the structure and function of the European Union’s (EU) newly introduced General Anti-Avoidance Rule (GAAR) affects the concept of tax avoidance in its member states. Through a comparative study of the Swedish and Danish approach to combating corporate tax avoidance, the dissertation focuses on both the pre-existing provisions against tax avoidance and the ru
Exposure to air pollution is associated with adverse health effects in humans, with special concern for exposure to fine particulate matter (PM2.5). The physicochemical properties of aerosols impact the health effects. Considering that we spend approximately 90% of our time indoors, it is important to gain increased understanding of indoor aerosol concentrations and properties. The overall aim of
The purpose of this study was to qualitatively evaluate recently introduced Model-based iterative reconstruction method (IMR) and routinely used iterative reconstruction algorithm iDose4 to investigate future dose reduction possibilities for abdominal CT exams. The study contained data from 34 patients who underwent abdominal CT in SkåneUniversityHospital Lund, Sweden. A low-dose scan (CTDIvol3.4
AIMS: Detecting changes in ventricular function after orthotopic heart transplantation (OHT) using transthoracic echocardiography (TTE) is important but interpretation of findings is complicated by lack of data on early graft adaptation. We sought to evaluate echocardiographic measures of ventricular size and function the first year following OHT including speckle tracking derived strain. We also
