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RNA therapeutics is a new class of targeted therapies that has entered the clinic in the last decade. Lipid nanoparticles (LNPs) and conjugation to N-acetylgalactosamine have proven to be efficient strategies to deliver RNA payload to the liver. Successful delivery of sensitive RNA molecules to other target tissues or tumors remains one of the key challenges with the development of new RNA-based t
Background: Photon-counting computed tomography (PCCT) is a new clinical method that may show better diagnostic quality at lower radiation doses than conventional CT. Objective: To investigate the diagnostic quality and radiation dose of paediatric cardiovascular PCCT for diagnosis of congenital heart defects at 70 kV and 90 kV. Materials and methods: This retrospective assessment included clinica
The term “Holocene temperature conundrum” refers to the inconsistencies between proxy-based reconstructions and transient model simulations, and it challenges our understanding of global temperature evolution during the Holocene. Climate reconstructions indicate a cooling trend following the Holocene Thermal Maximum, while model simulations indicate a consistent warming trend due to ice-sheet retr
SiC fibre reinforced metal matrix composites find widespread application but show major machining difficulties due to significant variations in constituents' properties. In this sense, while the SiC fibre plays significant strengthening effects, the properties mismatch between the brittle fibre and ductile matrix materials becomes important in their machining performance. Through machining tests,
Objective: To screen a general pediatric population for type 1 diabetes (T1D), celiac disease (CD), and autoimmune thyroid disease (AITD) after home capillary sampling. Methods: Swedish schoolchildren between 6–9 years and 13–16 years of age were invited to screening by taking a capillary sample at home. Samples were returned by mail and assessed for autoantibodies associated with T1D, CD, and AIT
Motivated by the analysis of the tunneling effect for the magnetic Laplacian, we introduce an abstract framework for the spectral reduction of a self-adjoint operator to a hermitian matrix. We illustrate this framework by three applications, firstly the electro-magnetic Laplacian with constant magnetic field and three equidistant potential wells, secondly a pure constant magnetic field and Neumann
A cubic DNA nanocage probe is able to enter EVs derived from MDA-MB-231 cells and react with miRNA-10b. The probe-loaded EVs were employed to monitor the process of entry of miRNA-10b into MCF-10A cells, allowing visualization of EV-mediated intercellular communication of miRNA-10b between the cancer cells.
The ribosome is an essential drug target as many classes of clinically important antibiotics bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is targeted by the broadest array of inhibitors belonging to several chemical classes. One of the most abundant and clinically prevalent mechanisms of resistance to PTC-acting drugs is C8-methylation of the universally
Boken är en syntes av Osmanska rikets historia från 1200-talet till 1900-talet.
Den nya högerledda regeringen i Finland under Petteri Orpo är i full färd med att göra genomgripande förändringar av den finska arbetsmarknadsmodellen. Det handlar om konflikträtten, lönebildningen, förhandlingssystemet och de sociala förmånerna:•Begränsad rätt till sympatiåtgärder och politiska strejker samt kraftigt ökade böter i samband med olagliga konfliktåtgärder•Statliga medlare får inte go
Many regularized methods, such as the lasso and ridge regression, are sensitive to the scales of the features in the data. As a consequence, it has become standard practice to normalize(center and scale) features such that they share the same scale. For continuous data, the most common strategy is standardization: centering and scaling each feature by its mean andand standard deviation, respective
1961 grundades en ny social rörelse i Sverige. Den fick namnet Kampanjen mot atomvapen (KMA) och var en svensk gren av en internationell, gränsöverskridande rörelse som startat året innan med bas i Västeuropa. Målet med rörelsen var att få supermakterna att avrusta sina kärnvapenrörelser och, för svensk del, att få Sverige att upphöra med sitt pågående kärnvapenprogram. I Sverige spelade KMA en viA new social movement was formed in Sweden in 1961: Kampanjen mot atomvapen (KMA, “The Campaign for Nuclear Disarmament”). Opposing the military’s plans to acquire Swedish nuclear bombs and protesting against the escalating tensions of the Cold War, KMA in the years 1961‒1963 rallied young people and students and introduced several new forms of collective political actions in the Swedish repertoir
Streaming applications, such as MPEG video encoders or sensor processing pipelines, are increasing in complexity as well as the diversity of platforms that they run on. The toolchains handling these applications must keep up with this increase at all levels of abstraction. The Actor Machine (AM) is an intermediate representation in the toolchain that we make use of. Large AMs are difficult to work
Rapporten presenterar resultaten av en studie som vi genomfört på uppdrag av Nätverket Idéburen Sektor Skåne och handlar om idéburna erfarenheter av samverkan med offentliga organisationer inom NAD. Syftet är att förstå hur strukturella förändringar och organisatoriska strategier har påverkat samverkan över tid. Tidsperioden sträcker sig från 2016 då vi genomförde en utvärdering av samverkan och 2
Ghana’s Land Administration Project (LAP), initiated in 2003, aimed to enhance certainty regarding land rights. What has been achieved since then? We explore landowners’ perceptions of tenure security in Ghana using micro-level data from two waves of the Ghanaian Living Standards Surveys: GLSS5+ (2008) and GLSS7 (2017). This data allows us to study the linkages between land title formality and per
Background The popularity of tattoos has increased dramatically over the last few decades. Tattoo ink often contains carcinogenic chemicals, e.g., primary aromatic amines, polycyclic aromatic hydrocarbons, and metals. The tattooing process invokes an immunologic response that causes translocation of tattoo ink from the injection site. Deposition of tattoo pigment in lymph nodes has been confirmed
Mennesker og trær har alltid hatt et nært fellesskap. Hva er det med trær, og hva har de med oss å gjøre? Historiker og teolog Thomas Arentzen oppsøker skoger, klatrer i trær, leser bibelske tekster og dykker ned i historiske kilder. Han finner mennesker som søker trær, men også trær som våker over mennesker. Trærnes evangelium er et essay om et landskap som på samme tid er hverdagslig og fantasti
In this chapter, focus is on the period 1945-1960 and the discussion is divided into three thematic sections: First, macro-economic structures including growth trends and the composition of the economies. Second, colonial budgets including state finance, fiscal capacity, and economic policy. Third, changes in occupations, incomes, and living standards primarily for the African subjects. The text p
