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Background: Combined CDK4/6 inhibitor (CDK4/6i) and endocrine therapy significantly improve the outcome of patients with advanced estrogen receptor-positive (ER+) breast cancer. However, resistance to this treatment and disease progression remains a major clinical challenge. High expression of the receptor tyrosine kinase REarranged during Transfection (RET) has been associated with resistance to

Introduction: Knee pain increases the risk of developing chronic widespread pain (CWP) and knee osteoarthritis (KOA). The prevalence of CWP and KOA has increased, and there is a need for early prevention. Therefore, the aim was to examine the associations of health-related quality of life (HRQoL) and lifestyle habits with chronic pain at a two-year follow-up in individuals with knee pain. Methods:

The advancement of disease-modifying treatments (DMTs) for Alzheimer's disease (AD), along with the approval of three amyloid-targeting therapies in the US and several other countries, represents a significant development in the treatment landscape, offering new hope for addressing this once untreatable chronic progressive disease. However, significant challenges persist that could impede the succ

During the evolution of parasites, co-speciation and host-range expansion are thought to play roles in establishing associations with hosts, while sorting events can lead to dissolution of those associations. To address the roles of these processes, we focus on avian haemosporidian parasites infecting hosts of the intensively studied great tit species complex. We estimated the phylogeography of li

Warfare has been commonly associated with increasing levels of inflation, with important implications for tax systems. In this chapter, we first review the literature on war finance and inflation, considering both the fiscal causes of inflation during wartimes and the effects of inflation on tax revenues. Second, we focus on developments in the income tax during the World Wars, building upon our p

This paper examines the distributive effects of personal income taxation in Sweden, the United Kingdom, and the United States during the first half of the 20th century. We estimate the evolution of marginal and average effective tax rates across the income distribution and calculate the corresponding indices of progressivity and redistribution. Our results show that redistribution through income t

In situ catalysis studies typically correlate catalytic function and majority surface structures, but neglect that difficult-to-detect minority structures might govern catalysis. Here we use an oscillating CO:O2 gas composition to drive structural oscillations on a catalytically active Pd(100) surface and collect X-ray photoelectron spectroscopy data at high measurement frequency to demonstrate th

Boken är en översiktlig syntes av det egyptiska pyramidbyggandet, från de första mastaborna till pyramidkonstruktionerna i Nubien.

Sustainable Aviation Fuels (SAF) are the most promising strategy for reducing the carbon emissions of aviation in the near term, but their combustion behavior is not well understood compared to conventional fuels. This work investigates how different properties of SAF may lead to different emergent combustion behavior by targeting a small set of very distinct fuels. The investigation is carried ou

Den visuella omvärlden kan vara dynamisk och föränderlig vilket skapar otydlighet i sensorisk information. Dessutom genererar hjärnans neurala aktivitet ”brus” som bidrar till denna otydlighet. Trots dessa svårigheter kan det visuella systemet i hjärnan bearbeta denna otydliga information och skapa en kontinuerlig och stabil visuell upplevelse, vilket låter oss navigera i omvärlden med trygghet. EThe visual environment can be dynamic and often changes from one moment to the next, causing sensory input to be noisy and uncertain. In addition, internal noise from neural activity in the brain contributes to this uncertainty. Despite these challenges, the brain’s visual system adeptly processes this noisy and uncertain information, creating a stable and continuous perceptual experience that all

När vi nu står inför en samhällelig strukturomvandling med digitalisering och AI-utveckling är många oroliga för att arbeten kommer att försvinna. Det kommer de säkert, men det kan också tillkomma nya jobb – om vi lär oss av historien och spelar våra kort rätt, skriver välfärdsforskaren Andreas Bergh och Joakim Wernberg, lektor i teknik och samhälle.

Green Hydrogen has been hailed as a game changer in climate actions, yet both global hydrogen markets and governance frameworks remain underdeveloped. The EU aims to pioneer a regulatory pathway, embedding hydrogen into its decarbonization governance framework. Centered on renewable hydrogen, the EU moves beyond “color-coding” technical classifications towards an emission-intensity-based legal def