Pharmacokinetic modeling for optimization of radioimmunotherapy – macroscopic and microscopic approach
Purpose: For evaluation, development and optimization of treatment strategies in radionuclide therapy, it is useful to study and model the pharmacokinetics of the therapeutic agent. The aim of this study was to create models for describing the pharmacokinetics of monoclonal antibodies used for radioimmunotherapy.Method: Two models, based on very different modeling approaches, are presented in this