Optimizing the direct reprogramming of human glial cells into parvalbumin interneurons
Inhibitory neurons or interneurons are important regulators of brain signaling. Parvalbumin (PV) interneurons, the most common interneuron subtype, have the unique ability to fire a rapid train of action potentials. They regulate the activity of pyramidal neurons to promote appropriate behavioral responses. Cortical PV interneurons’ function is greatly diminished in neuropsychiatric disorders e.g.