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Spinal and bulbar muscular atrophy is a hereditary motor neuron disease caused by trinucleotide repeat expansion in the androgen receptor gene. The disease mechanism probably involves a toxic gain of function in the mutant protein, because other mutations that cause a loss of androgen receptor function result in a different phenotype and the mutant protein is toxic in mouse models. In these models
Unlike most modernist fiction, Dorothy Richardson’s Pilgrimage not only recognizes but celebrates silence as a strength in life and literature alike. Richardson’s silence is one which enables, communicates, and reveals truth. It speaks in a way words never can; ‘[r]eal speech can only come from complete silence’, as Miriam concludes (III, 389). This article explores the role silence plays in Pilgr
BACKGROUND: Aggregates formed between leukocytes and platelets in the circulation lead to release of tissue factor (TF)-bearing microparticles contributing to a prothrombotic state. As enterohemorrhagic Escherichia coli (EHEC) may cause hemolytic uremic syndrome (HUS), in which microthrombi cause tissue damage, this study investigated whether the interaction between blood cells and EHEC virulence
BACKGROUND: Physical activity (PA) is part of a healthy lifestyle and prevents many chronic health problems, in addition to promoting mental health. PA performed outdoors has been found particularly good for promoting one's well-being. The aim of this study was to investigate the extent to which outdoor recreational PA was carried out during 1 year, and the factors influencing such activities from
Objective: The aim of current study was to evaluate the changes of health-related quality of life (HRQoL) and its clinical, demographic and socioeconomic determinants during chemotherapy and 4 months follow-up in women with breast cancer using a repeated measures framework. Methods and Materials: A double blind cohort study was performed in 100 breast cancer patients given fluorouracil, doxoru
Abstract is not available
A presentation and discussion of the results of the pilot excavations at 1 existing and 5 deserted farms, which took place as part of the investigation of the Medieval rural settlements in Bornholm. The settlements on the sites could not be traced back prior to the 16th-17th C.
From 1989 to 2005, 13 patients aged between 5 and 18 years had testicular prostheses implanted at the Department of Plastic and Reconstructive Surgery, University Hospital, Malmö, Sweden. The most common indication for surgery was aplastic or vanishing testes. In 13 patients and 19 operations 7 unilateral and 12 bilateral testicular prostheses were implanted. Each prosthesis was implanted through
The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high level of anti-tumor activity. In spite of this important progress, however, nearly all MM patients ultimately relapse, even those who experience a complete response to initial therapy. Management of rel
Cigarette smoke exposure is well known to cause cardiovascular and airway diseases, both of which are leading causes of death and disability in the world. However, the molecular mechanisms that link cigarette smoke to cardiovascular and airway diseases are not fully understood. Vascular and airway hyper-reactivity plays an important role in the pathogenesis of cardiovascular and airway diseases. R
In addition to classical neurological symptoms, Huntington's disease (HD) is complicated by peripheral pathology and both the mutant gene and the protein are found in cells and tissues throughout the body. Despite the adipose tissue gene expression alterations described in HD mouse models, adipose tissue and its gene expression signature have not been previously explored in human HD.
