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Objective In patients with Crohn’s disease (CD) on combination therapy (infliximab and immunosuppressant) and stopping infliximab (cohort from the study of infliximab diSconTinuation in CrOhn’s disease patients in stable Remission on combined therapy with Immunosuppressors (STORI)), the risk of short-term (≤6 months) and mid/long-term relapse (>6 months) was associated with distinct blood protein

De senaste teknologiska framstegen har lett till skapandet av högspecialiserade system inom olika industrier, vilket möjliggör uppgifter som tidigare varit otänkbara. I takt med att den globala efterfrågan på hållbara och effektiva energilösningar ökar, har behovet av innovation inom teknik aldrig varit större. Dessa framsteg representerar transformativa förändringar som omformar hela sektorer. FrRecent technological advancements have led to the creation of highly specialized systems across various industries, enabling tasks that were once beyond imagination. As the global demand for sustainable and efficient energy solutions grows, the urgency for innovation in technology has never been greater. These advancements are not simply incremental but represent transformative changes that are re

Respiratory viruses such as Influenza A virus (IAV) pose a significant burden on UK healthcare, especially in winter months. The drivers of the seasonal increase in IAV infection rates include environmental conditions, viral genetic variation, host immunity and human behaviour. This project aims to investigate the impact of environmental conditions on IAV airborne stability, thus improving our und

Warmer temperatures and the combined effects of wind and water erosion leads to serious soil loss. Identifying the contribution of different drivers to wind and water compound erosion can improve soil erosion management in the watershed. Accordingly, we calculated the erosion energy based on energy theory and applied the mutation test and trend analysis to explore environmental drivers, runoff, an

Enzymes, as efficient and environmentally friendly catalysts, have gainedsignificant scientific and industrial attention for their mild operating conditions,high substrate selectivity and reusability when immobilized. Among them, lipasesdominate the global industrial enzyme market, catalyzing various reactions with afocus on substrate specificity and selectivity. This thesis investigates theoptimi

Purpose: Resilience has been suggested as an important predictor of both physical and mental health-related quality of life in breastcancer patients. However, it is unclear why resilient women handle their diagnosis better, not only mentally, but also physically. Theaim of this study was to investigate paths between resilience, physical activity, and mental, physical, and global health-related qua

Antithrombotic therapies (ATT) play a pivotal role in the management of cardiovascular diseases, aiming to prevent ischemic events while maintaining a delicate balance with the patient’s bleeding risk. Typically, ATT can be classified into antiplatelet and anticoagulant therapies. Their application spans a broad spectrum of cardiovascular conditions, ranging from ischemic heart disease to atrial f

We theoretically investigate nondipole effects in the reconstruction of attosecond beating by interference of two-photon transitions (RABBIT) of helium using linearly polarized extreme ultraviolet and infrared fields. By scanning the time delay between the two fields, we observe modulations in sidebands (SBs) both for angular-integrated photoelectron yield and forward-backward asymmetry in photoel

This essay does not claim to be a gender and quantitative analysis of rescue. Its modest aim is to discuss complexities and difficulties of studying the subject of rescue of Jews in wartime Poland from a gender perspective. The initial analysis put forward here is intended to investigate to what extent gender mattered in the treatment of the non-Jewish Polish rescuers by members of their local com

Elevated ozone (eO3) and atmospheric nitrogen (N) deposition are important climate change components that can affect plant growth and plant-soil-microbe interactions. However, the understanding of how eO3 and its interaction with N deposition affect soil microbially mediated carbon (C) cycling and the fate of soil C stocks is limited. This study aimed to test how eO3 and N deposition affected soil

Antibiotic resistance genes (ARGs) are widespread in the environment, and soils, specifically, are hotspots for microorganisms with inherent antibiotic resistance. Manure and sludge used as fertilizers in agricultural production have been shown to contain vast amounts of ARGs, and due to continued applications, ARGs accumulate in agricultural soils. Some soils, however, harbor a resilience capacit

Vertebral compression fractures (VCFs) are common and indicate a high future risk of additional osteoporotic fractures. However, many VCFs are unreported by radiologists, and even if reported, many patients do not receive treatment. The purpose of the study was to evaluate a new artificial intelligence (AI) algorithm for the detection of VCFs and to assess the prevalence of reported and unreported

A French book relating to flea literature has recently been discovered at the National Library of Sweden in Stockholm. This article claims to be the first presentation of the work Histoire d’une puce by Louis Marie Céleste d’Aumont, Duke of Piennes (1762-1831), with the first literary analysis of its erotic content. The second half of the story is remarkable for the presence of Swedish words in th

Bioenergy derived from agricultural biomass can contribute to meeting the rising demand for renewable energy. To estimate the agricultural sector's potential to contribute to bioenergy, it is crucial to understand what motivates farmers to increase agricultural feedstock production sustainably. Through eight semi-structured interviews and online surveys with 174 farmers in southern Sweden, we expl

The analysis of the interaction between main bionts (mycobiont and photobiont) in the lichen symbiosis delivers substantial information about their preferences in the selection of symbiotic partners, and their ecological preferences. The selectivity in the Parmelia genus has been defined as strong so far. However, data on this lichen genus, which includes several widely distributed species, are bi

Oligomeric species arising during the aggregation of α-synuclein are implicated as a major source of toxicity in Parkinson’s disease, and thus a major potential drug target. However, both their mechanism of formation and role in aggregation are largely unresolved. Here we show that, at physiological pH and in the absence of lipid membranes, α-synuclein aggregates form by secondary nucleation,

We show that resonant absorption of smooth laser fields can yield Mollow-like triplet patterns. General conditions for such triplets are derived and illustrated with a super-Gaussian pulse sequence. Gaussian pulses cannot exhibit triplets, super-Gaussian pulses can form triplets depending on the pulse area, and flattop pulses can produce absorption triplets after one Rabi cycle. Our results are co