Self-assembly of chiral bicyclic keto-alcohols into supramolecular helices in the solid state
The bicyclic keto-alcohol (1S,4R,6S)-bicyclo[2.2.2]octan-6-ol-2-one, (+)-3, self-assembles in the solid state through hydrogen bonds between the alcohol and the carbonyl groups creating supramolecular helices, without the aid of other forces such as pi-pi interactions to stabilise the superstructure. Furthermore, the bicyclic compound (4) although structurally quite different, in relation to (+)-3