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BACKGROUND: Neuroblastoma (NB) is a childhood cancer with a high relapse rate despite intensive treatment. TRPA1 is a pain-sensing ion channel with downstream impacts on proliferative and pro-apoptotic pathways. Here, we evaluated TRPA1 expression in NB and performed pharmacological inhibition in preclinical models to assess its potential as a therapeutic target in NB.METHODS: TRPA1 protein levels
OBJECTIVES: The Sepsis-3 definition states the clinical criteria for sepsis but lacks clear definitions of the underlying infection. To address the lack of applicable definitions of infection for sepsis research, we propose new criteria, termed the Linder-Mellhammar criteria of infection (LMCI). The aim of this study was to validate these new infection criteria.DESIGN: A multicenter cohort study o
We present and analyze a hybridizable discontinuous Galerkin method for coupling Stokes and Darcy equations, whose domains are discretized by two independent triangulations. This causes nonconformity at the intersection of the subdomains or leaves a gap (unmeshed region) between them. In order to properly couple the two different discretizations and obtain a high-order scheme, we propose suitable
Article 12 of the UN Convention on the Rights of Persons with Disabilities requires states parties to take appropriate measures to ensure that persons with disabilities have access to the support they may need in exercising their legal capacity. However, this obligation remains ambiguous. What exactly is decision-making support meant to accomplish? Until this fundamental issue has been clarified,
While the 8.2 ka abrupt cooling event is increasingly recognised as a major Holocene climatic anomaly, archaeological discussions of its cultural consequences have often been framed in terms of societal distress, including the collapse and abandonment of settlements. However, prehistoric communities must have responded in more diverse ways. This paper investigates the site-based socio-ecological a
Ornamental horticultural plants in domestic gardens can constitute a substantial dispersal pool of potentially invasive species. Understanding garden owners' preferences when selecting plants, their awareness of dispersal pathways and how they manage their gardens is critical for effective invasive species control. This study used a survey to investigate Swedish garden owners' (n = 743) plant seleOrnamental horticultural plants in domestic gardens can constitute a substantial dispersal pool of potentially invasive species. Understanding garden owners' preferences when selecting plants, their awareness of dispersal pathways and how they manage their gardens is critical for effective invasive species control. This study used a survey to investigate Swedish garden owners' (n = 743) plant sele
Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal dystrophies (IRDs) and ciliopathies. USP48 is a deubiquitinating enzyme whose role in the retina is still unexplored although previ
Electricity grids are essential to industrialized societies, yet they are increasingly unable to meet the dual demands of increased electrification and electricity system decarbonization. Smart grids offer a solution to these challenges by integrating information and communication technologies into the physical grid. However, despite their potential, smart grid implementations often fail to delive
The desire for a deeper connection with nature has become increasingly apparent. The shift towards eco-conscious living, as demonstrated by the popularity of gorpcore and the nomad lifestyle, shows that people want to make more sustainable and nature-inspired choices. In response to this cultural shift, I am motivated to channel these environmental sentiments into a design project — the creation
Over-indebtedness is at an all-time high in Sweden. The purpose of this study was to examine the relationships between financial literacy, coping strategies, and consumer financial behaviour. A further aim was to examine gender differences in this context. The study employed a cross-sectional survey design, in which participants (n = 2057) responded to questions related to the study variables. The
PARP15 is a mono-ADP-ribosyltransferase that targets an unknown set of proteins as well as RNA. Its evolutionary relationship with PARP14 suggests roles in antiviral defence; its localization to stress granules points to functions in the regulation of translation. Here we show that the transferase domain of PARP15 dimerizes in solution; the formation of dimers is a prerequisite for catalytic activ
Aliphatic polycarbonates are prepared by ring opening polymerization of six-membered cyclic carbonates or various ratio of mixtures of six-membered cyclic carbonates using catalysts. The resulting materials are further polymerized using the extra functional group such as additional 2nd cyclic carbonate, (meth)acrylate and allylate. This process and material(s) obtained provide chlorine (e.g. phosg
At the intersection of environmental histories of war, fascism and urban parks, this article analyses the transformation of the political meaning attached to the green spaces of Madrid’s University City. Conceived in the late 1920s as a ‘university park’ inspired by North American academic campuses, the ‘Ciudad Universitaria’ was heavily damaged during the Spanish Civil War (1936–1939). The subseq
In its Advisory Opinion on the Legal Consequences arising from the Policies and Practices of Israel in the Occupied Palestinian Territory, including East Jerusalem, the International Court of Justice (ICJ) ruled not only that Israeli policies and practices in the occupied territory systematically violated international law, but also that Israel’s ‘continued presence’ (i.e. occupation) as such had
USP11 is a promising therapeutic target implicated in Alzheimer’s disease and various cancers; however, no specific inhibitors are currently available, with the only known inhibitor being mitoxantrone, which primarily targets topoisomerase II. To identify novel chemical starting points, we conducted high-throughput virtual screening using a USP11 homology model. Screening over 600,000 compounds yi
Personality traits (e.g., the Big Five) shape human behavior, decision-making, and life outcomes. Evidence from various countries suggests that these traits are not randomly distributed but follow systematic regional patterns, fueling interest in their geographical variation. We analyze N = 22,225 geo-coded personality assessments, aggregated at regional levels. Using Hot Spot analysis (Getis-Ord
