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Background We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma. Methods EURAMOS-1 was an open-label, international, phase 3 randomised, controlled trial. Consenting patients with newly diag
Att en specifik utvärderingsforskning knappast existerade i Sverige före mitten av 1970-talet beror bl a på att socialpolitiska reformer normalt föregåtts av en planerings- och beslutsprocess som inneburit omfattande politisk kontrol och värdering, såväl före som under själva genomförandet. Förändringarna inom offentlig sektor, där det tidligare planeringstänkandet ersatts av en mål- och resultats
Several ribonucleases of the RNase A family function as antibacterial, anti-parasitic and anti-viral agents. In this work, we have shown that mRNAs encoding five of the six known human ribonucleases of the RNase A family are expressed in cultured human monocytes, and that ribonucleases are released by adherent monocytes in culture. Using a polyclonal antiserum prepared against recombinant protein,
(+)-5,6-Epoxy-bicyclo[2.2.1]heptane-2-one, (+)-1, and endo-(−)-5,6-epoxy-bicyclo[2.2.1]heptane-2-ol, endo-(−)-2, were obtained by kinetic resolution of rac-1 by asymmetric bioreduction catalyzed by whole cells of a genetically engineered Saccharomyces cerevisiae yeast strain. The strain, TMB4100, had 1% phosphoglucose isomerase (PGI) activity and overexpressed a specific short-chain dehydrogenase,
This article deals with copyright regulation meeting the quite rapid societal changes associated with digitization, and it does so by reinterpreting Karl Renner's classical texts in the light of contemporary cognitive theory of conceptual metaphors and embodiment. From a cognitive theory perspective, I focus on the notion that the legal norms only appear to be unchanged—the Renner distinction betw
Group G streptococcus (GGS) is a human bacterial pathogen expressing surface proteins FOG and protein G (PG) which interact with several host defense systems, including the complement and contact systems. Selected reaction monitoring mass spectrometry, electron microscopy, and protein binding assays were used to follow the amounts of FOG and PG intracellularly and on the bacterial surface during d
We introduce partially defined dynamical systems defined on a topological space. To each such system we associate a functor s from a category G to Topop and show that it defines what we call a skew category algebra A ⋊ G. We study the connection between topological freeness of s and, on the one hand, ideal properties of A ⋊ G and, on the other hand, maximal commutativity of A in A ⋊ G. In particul
Human telomerase reverse transcriptase (TERT) encodes a rate-limiting catalytic subunit of telomerase that maintains genomic integrity. TERT expression is mostly repressed in somatic cells with exception of proliferative cells in self-renewing tissues and cancer. Immortality associated with cancer cells has been attributed to telomerase over-expression. The precise mechanism behind the TERT activa
This report is a fire safety evaluation of the hospital Lasarettet i Landskrona, Sweden. The main objective was to guarantee the safety during evacuation in case of a fire in three of the hospitals infirmaries. This was done by a closer examination of one of these infirmaries. No regard has been taken for economic or environmental aspects, this report focuses only on human safety. Three fire scena
This paper investigates the association between infant mortality and macroeconomic shocks in the Dominican Republic, using the 2002 and 2007 Demographic and Health (DHS) surveys. The article starts by reviewing the recent evolution of macroeconomic and social indicators in the country, as well as infant mortality trends calculated from the DHS surveys. It then proceeds to estimate logit and s
During the last decade women in Sweden have reduced men’s lead in participation in mathematics education and in professional careers as mathematicians. However, the development is uneven and slow overall. In some areas and at the highest levels women have increased their participation only marginally. Why, one may ask, is progress so slow after almost twenty years of active work from the Women and
