Filtyp
The focus of this article is to examine a specific case of a failing regional innovation system (RIS). Our study focuses on a specific project that was conducted in a triple helix constellation where public actors occupy the centre of the triple helix constellation. By examining and interpreting this single case, we aim to illustrate the consequences that result from uncertainty over who the tripl
Background: Community services for Swedish people with intellectual disability (ID) are intended to support self-determination and integrity. Legislation does not allow the use of restrictive or coercive measures. Aim: The aim of this study is to identify the extent of, rationale for, and strategies staff believe would reduce the use of restrictive measures in group homes and daily activities serv
Parkinson’s disease (PD) can produce postural abnormalities of the standing body position such as kyphosis. We investigated the effects of PD, deep brain stimulation (DBS) in the subthalamic nucleus (STN), vision and adaptation on body position in a well-defined group of patients with PD in quiet standing and during balance perturbations. Ten patients with PD and 25 young and 17 old control partic
Aggression is a known problem in individuals being cared for in forensic settings, yet the evidence base for its treatment is scarce. Virtual Reality (VR) has been proposed as a promising addition to interventions in forensic settings, as it may increase the motivation among participants, bridge the gap between real life, therapeutic and laboratory experiences, and increase the ecological validity
Inhomogeneous magnetic transfer (ihMT) is more sensitive to myelin macromolecules than standard MT proxies. Measuring ihMT in the multi-parameter mapping protocol allows calculating ihMT from MT saturation (MTsat) maps and thus inherently correct for the undesired dependencies on flip angle and the longitudinal relaxation rate. Further validation of this new ihMT metric requires measurement of MPM
Background: Involving service users in inpatient care and recovery planning has gained interest worldwide. Our purpose was to evaluate the process of implementation of a coproduced Recovery Guide (RG) intervention in 22 inpatient wards in Sweden, in terms of context, implementation process and mechanisms of impact over 12 months.Methods: A mixed method design and a process evaluation framework wer
The skate Leucoraja erinacea has an elaborately shaped pupil, whose characteristics and functions have received little attention. The goal of our study was to investigate the pupil response in relation to natural ambient light intensities. First, we took a recently developed sensory-ecological approach, which gave us a tool for creating a controlled light environment for behavioural work: During a
The present paper shows that cross‐section demeaning with respect to time fixed effects is more useful than commonly appreciated, in that it enables consistent and asymptotically normal estimation of interactive effects models with heterogeneous slope coefficients when the number of time periods, T , is small and only the number of cross‐sectional units, N , is large. This is important when using
Background: Several neurotransmitters are expressed in the neurons of the trigeminal ganglion. One such signalling molecule is the pituitary adenylate cyclase-activating peptide (PACAP). PACAP signalling has been suggested to have a possible role in the pathophysiology of primary headaches. Objective: The present study was designed to investigate the relationship between PACAP and calcitonin gene-
Mammalian dihydroorotate dehydrogenase, the fourth enzyme of pyrimidine de novo synthesis is an integral protein of the inner mitochondrial membrane that faces the intermembrane space and is functionally connected to the respiratory chain via ubiquinone. Here, we describe the first cloning and analyzing of the complete cDNA of mouse dihydroorotate dehydrogenase. Based on our recent functional expr
BACKGROUND: Alzheimer's disease (AD) is one the most common types of dementia. Plaques of amyloid beta and neurofibrillary tangles of tau are two major hallmarks of AD. Metabolism of these two proteins, in part, depends on autophagy pathways. Autophagy dysfunction and protein aggregation in AD may be involved in a vicious circle. The aim of this study was to investigate whether tau or amyloid beta
Urban flood risk is a big and growing concern, particularly in relation to climate change. The complexity of this problem poses distinctive challenges to a broad range of actors involved in various ways in flood risk governance, as well as to the social scientists endeavoring to grasp them. These challenges are related both to the complexity of risk and risk perception as such, which attract a lot
This chapter analyses the roles and activities of multinational companies (MNCs) in an entrepreneurial ecosystem (EE) and local start-up incubation. Drawing from literature regarding EEs and incubation policy, we present an example of a type of intervention under-theorized to date: incubation efforts stemming from MNCs rather than government or universities. Presenting the case of Microsoft Innova
This chapter examines ethical guidelines as a tool for the governance of artificial intelligence (AI). Analysing the European development towards a trustworthy AI, with a focus on the High-Level Expert Group on AI appointed by the European Commission, the chapter highlights the interaction between guidelines and law in light of technological advancements. It discusses why contemporary AI has led t
Safety in density (SID) potentially explains the safety in numbers (SIN) phenomenon by positing that ‘the SIN effect can be reproduced simply through encouraging behaviour that leads to the formation of higher-density cyclist groups’. The study further explores this hypothesis using event-based exposure, queues and groups of road users. Using three different definitions of encounters between road u
We study a two component Bose-Einstein condensate in the presence of an inhomogeneous artificial gauge field. In response to this field, the condensate forms a localised vortex lattice structure that leads to a non-trivial symmetry breaking in the phase separated regime. The underlying physical mechanism can be understood by considering the energy landscape and we present a simplified model that i
Background: People with severe mental illness (SMI) living in supported housing (SH) struggle in everyday life and we currently lack a comprehensive body of knowledge concerning how the residents experience their day. This paper aimed to gain knowledge about how people with SMI describe a day in SH in Sweden, in particular the activities they most frequently engage in and how they experience what
Objective Survival in epithelial ovarian cancer (EOC) remains poor. Most patients are diagnosed in late stages. Early diagnosis increases the chance of survival. We used the proximity extension assay from Olink Proteomics to search for new protein biomarkers with the potential to improve the diagnostic performance of CA125 and HE4 in patients with ovarian tumors. Material and methods Plasma sample
Based on extensive qualitative (interviews, n50) and quantitative data (survey questionnaire, n3200), this paper identifies management – and not only managerial regimes – as a problem in in public sector work places. The paper specifically explores what nurses and social workers identify as central areas of conflict shaping their work, and what forms of structural and organizational change they vi
The preservation of labile biomolecules presents a major challenge in chemistry, and deep eutectic solvents (DESs) have emerged as suitable environments for this purpose. However, how the hydration of DESs impacts the behavior of proteins is often neglected. Here, we demonstrate that the amino acid environment and secondary structure of two proteins (bovine serum albumin and lysozyme) and an antib
