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Background: Pancreatic cancer and other pancreaticobiliary type periampullary adenocarcinomas have a dismal prognosis even after resection and neoadjuvant chemotherapy. Intestinal type periampullary adenocarcinomas generally have a better prognosis, but little is known on optimal neoadjuvant and adjuvant treatment. New prognostic and treatment predictive biomarkers are needed for improved treatmen
OBJECTIVE-To evaluate the significance of GAD antibodies (GADAs) and family history for type 1 diabetes (FHT1) or type 2 diabetes (FHT2) in nondiabetic subjects. RESEARCH DESIGN AND METHODS-GADAs were analyzed in 4,976 nondiabetic relatives of type 2 diabetic patients or control subjects from Finland. Altogether, 289 (5.9%) were GADA(+)-a total of 253 GADA(+) and 2,511 GADA(-) subjects participate
The integration of scheduling and control in the process industry is a topic that has been frequently discussed during the recent years, but many challenges remain in order to achieve integrated solutions that can be implemented for large-scale industrial sites. In this paper we consider production control under disturbances in the supply of utilities at integrated sites together with the integrat
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Familjär hypertrof kardiomyopati (HCM) är den vanligaste ärftliga hjärtsjukdomen som ärvs autosomalt dominant, dvs. ca 50% risk för varje barn i den drabbade familjen. Tidigare studier har visat hög risk för HCM relaterade tillbud inklusive plötslig hjärtdöd (SCD) under barndomen, med en incidens upp till 10 % under de två första decenFamilial hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease, transmitted in an autosomal dominant fashion, i.e. 50% risk for transmission of the disease-causing mutation to each child of the affected family. Previous studies reveal a high risk for HCM related cardiac events including sudden cardiac death (SCD) during childhood, with a peak incidence of up to 10% during th
Background-Late mortality after repair of total anomalous pulmonary venous connection is frequently associated with pulmonary venous obstruction (PVO). We aimed to describe the morphological spectrum of total anomalous pulmonary venous connection and identify risk factors for death and postoperative PVO. Methods and Results-We conducted a retrospective, international, collaborative, population-bas
Background: Estimations of the risk of bisphosphonate associated atypical femoral fractures vary between different population-based studies, from considerable to neglectable. A possible explanation for these discrepancies could be different definitions of atypical fractures. We aimed to identify specific radiographic fracture characteristics associated with bisphosphonate use. Methods: In a previo
Magnetic shape-memory Heusler alloys are multiferroics stabilized by the correlations between electronic, magnetic, and structural order. To study these correlations we use time-resolved x-ray diffraction and magneto-optical Kerr effect experiments to measure the laser induced dynamics in a Heusler alloy Ni2MnGa film and reveal a set of time scales intrinsic to the system. We observe a coherent ph
Popular Abstract in Swedish Denna avhandling behandlar strömlinjeformade subglaciala bäddformer (ofta kallade drumliner) i södra Sverige. Det övergripande syftet med denna studie är att bidra till en lösning av det så kallade ”drumlinproblemet”. Termen drumlin har kommit att tillämpas på en grupp av landformer vars interna sediment, strukturella uppbyggnad och yttre form kan variera kraftigt. DessThis thesis investigates stream-lined subglacial bedforms (often referred to as drumlins) in southern Sweden. The broad aim of this is to contribute to the solution of the ‘drumlin problem’. The term drumlin has come to be applied to a wide range of features whose internal architecture (core) and overall morphology are seen to vary greatly. This range in characteristics is in part responsible for
The transfer of 210Po and 210Pb between various compartments in the terrestrial environment has been analysed by using various published data. The average activity concentration of 210Po in soil is 61 ± 14 Bq.kg-1 d.w. with a median (50%) value of 44 Bq.kg-1 d.w. Ground water concentrations of 210Po in drilled wells might be as high as 6.5 Bq/l. But in regular drinking water it is just about 3-5
Candelaria concolor was recently revised and the majority of the Scandinavian collections was found to belong to C. pacifica. Candelaria concolor is a rare species with a southwestern distribution in the Nordic countries. It is growing on deciduous trees in open landscapes. Maps of the distribution of the two species in the Nordic countries are presented.
Many buildings, both new and old, suffer from moisture-related problems, with negative consequences on health, costs for rebuilding and lost confidence in the building industry. These problems could have been avoided if moisture issues had been focused on and dealt with throughout the building process. A method for including moisture safety in the building process has therefore been developed. The
Intergovernmental collaboration in the area of big science has been an important resource for European science since the 1950s. Yet, as a policy area, it has traditionally been left outside of the political integration work of the European Community/Union. Despite this formal detachment, the political realities of the collaborations often draw upon and reflect the (geo)political dynamics of Europe
This paper investigates explanations of variation in the development of capital asset volume between Swedish local governments, 1999–2008. As a pre-study, four cases were performed, generating 7 suggested explanatory factors. Hypotheses were generated by combining the suggested factors with a new political economy framework, containing two general assumptions. A national dataset of Swedish local g
Metabolomic screening of fasting plasma from nondiabetic subjects identified alpha-hydroxybutyrate (alpha-HB) and linoleoyl-glycerophosphocholine (L-GPC) as joint markers of insulin resistance (IR) and glucose intolerance. To test the predictivity of alpha-HB and L-GPC for incident dysglycemia, alpha-HB and L-GPC measurements were obtained in two observational cohorts, comprising 1,261 nondiabetic
Background: The metabolism of amyloid precursor protein (APP) and beta-amyloid (A beta) is widely studied in Alzheimer's disease, where A beta deposition and plaque development are essential components of the pathogenesis. However, the physiological role of amyloid in the adult nervous system remains largely unknown. We have previously found altered cerebral amyloid metabolism in other neuroinflam
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and function to produce and regenerate the entire blood and immune system over the course of an individual's lifetime. Historically, HSCs are among the most thoroughly characterized tissue-specific stem cells. Despite this, the regulation of fate options, such as self-renewal and differentiation, has remained elusi
Population genetic structure was studied in paddyfield warblers Acrocephalus agricola breeding in NE Bulgaria, SE Russia and S Kazakhstan. We were particularly interested in the degree of genetic differentiation and gene flow of the Bulgarian population due to its geographical isolation, recent origin and unique migratory strategy. Analyses of mitochondrial DNA (mtDNA) showed that there was no div
Early childhood education in Sweden has long had an international reputation for being a systemic and integrated approach to children’s needs, a family model of preschool centers and an interest in the holistic development and well-being of children. Recent changes occurring in Europe and elsewhere in education along with the reforms implemented by the Conservative government that has been in powe
Requirements communication plays a vital role in development projects in coordinating the customers, the business roles and the software engineers. Communication gaps represent a significant source of project failures and overruns. For example, misunderstood or uncommunicated requirements can lead to software that does not meet the customers’ requirements, and subsequent low number of sales or add
Modelling of the ultrafiltration process is crucial for effective optimization of full-scale modules, and considerable effort has been devoted to describing the permeate flux during ultrafiltration. Many models use a detailed description of the mass transport and are thus valuable for the understanding of the fundamental mechanisms of ultrafiltration. However, for the prediction of the flux in mul
