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Skeletal development is tightly regulated through the processes of chondrocyte proliferation and differentiation. Although the involvement of transcription and growth factors on the regulation of skeletal development has been extensively studied, the role of cell cycle regulatory proteins in this process remains elusive. To date, through cell-specific loss-of-function experiments in vivo, no cell

In this study, we present an analysis of gender assignment tendencies in Jamtlandic, a language variety of Sweden, using a word list of 1029 items obtained from fieldwork. Most research on gender assignment in the Scandinavian languages focuses on the standard languages (Steinmetz 1985; Källström 1996; Trosterud 2001, 2006) and Norwegian dialects (Enger 2011, Kvinlaug 2011, Enger & Corbett 20

The colours of insects serve important visual functions in aiding mate recognition, camouflage and warning. The display of insects is usually static, as cuticle coloration does not (or hardly) change during the lifespan of a mature imago form. Here, we describe a case of humidity-dependent, brilliant coloration in the green forester moth, Adscita statices. We show, by employing spectroscopic and u

This article studies the implementation of the global norm of women’s inclusion in the Malian peace negotiations. It constructs a theoretical framework for analyzing practices of resistance, which object to the validity of the norm, and practices of refinement, which engage with the application of the norm. Based on interviews with women who attended the Malian peace negotiations it finds that wom

För att mildra förlusten av biologisk mångfald i jordbruksmarker, inklusive dess pollinatörer, har många ansträngningar ägnats åt att bevara naturbetesmarker och slåtterängar. Dock är redan förlorade naturbetesmarker och slåtterängar svåra att återställa och kostsamma att hantera för ökade fördelar för biologisk mångfald. Dessutom är idag många marker som tidigare användes till slåtterängar nu betTo mitigate loss of farmland biodiversity, including insect pollinators, much effort has been spent on preserving semi-natural grasslands. However, already lost grasslands are difficult to restore and costly to manage for increased benefits to biodiversity. Previously often mowed semi-natural grasslands are today mostly managed by grazing, resulting in a lack of critical floral resources for many

Biomarkers have revolutionized scientific research on neurodegenerative diseases, in particular Alzheimer’s disease, transformed drug trial design, and are also increasingly improving patient management in clinical practice. A few key cerebrospinal fluid biomarkers have been robustly associated with neurodegenerative diseases. Several novel biomarkers are very promising, especially blood-based mar

Objective: Estimate the time-course of the spread of key pathological markers and the onset of cognitive dysfunction in Alzheimer's disease. Methods: In a cohort of 335 older adults, ranging in cognitive functioning, we estimated the time of initial changes of Aβ, tau, and decreases in cognition with respect to the time of Aβ-positivity. Results: Small effect sizes of change in CSF Aβ42 and region

In our solar system, terrestrial planets and meteoritical matter exhibit various bulk compositions. To understand this variety of compositions, formation mechanisms of meteorites are usually investigated via a thermodynamic approach that neglects the processes of transport throughout the protosolar nebula. Here, we investigate the role played by rocklines (condensation/sublimation lines of refract

Odd-frequency (odd−ω) electron pair correlations naturally appear at the interface between BCS superconductors and other materials. The detection of odd−ω pairs, which are necessarily nonlocal in time, is still an open problem. The main reason is that they do not contribute to static measurements described by time-local correlation functions. Therefore, dynamical measurements, which depend on nonl

Objectives: To explore the preoperative, intraoperative, and postoperative dynamics of heparin-binding protein (HBP) in cardiothoracic surgery. Design: This was a prospective, observational study. Setting: The study was conducted at a single university hospital. Participants: Thirty patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) were included, 15 of whom underwent coronary a

Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five decades ago, but remains largely unexplored. Here we report that METTL9 is a broad-specificity methyltransferase that mediates the formation of the majority of 1MH present in mo

The fusion-evaporation reaction 28Si+40Ca at 122 MeV beam energy was used to populate excited states in the N=Z+1 nucleus 63Ga. With the combination of the Gammasphere spectrometer and the Microball CsI(Tl) charged-particle detector array, the level scheme of 63Ga was extended by more than a factor of two in terms of number of γ-ray transitions and excited states, excitation energy (Ex>30 MeV), an