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γ-Trace is a low molecular weight human protein with unknown function, occurring in body fluids. this thesis deals with the determination of the complete amino acid sequenceof human -trace, its localization to neuroendocrine cells and concentration in human body fluids at various ages.γ-Trace was isolated from human urine, and antisera specific for -trace were raisedin rabbits.An enzyme immunoassa
Globally, transport increases its share of emissions and the transport sector desperately needs an efficient climate policy including efficient strategies to reduce unsustainable levels of car use. By providing insights into the profile of passenger mileage by car in relation to levels estimated to be sustainable in 2050, this work gives insight into who will, and who needs to, be affected by poli
A standardized personal interview schedule was used to study occupational exposure to organic solvents among 25 men aged 20-65 a with Hodgkin's disease and 50 referents matched for sex, age and residence. When exposure was defined as the handling of organic solvents every workday for at least 1 a within the 10-a period immediately preceding the interview, 12 of the Hodgkin's disease patients (48%)
Southern travelling habits were recorded for 127 melanoma patients from southern parts of Sweden (the 56th latitude), 55 thyroid cancer patients, 100 non-Hodgkin's patients and 794 healthy controls from the same region. Melanoma patients were found to travel significantly more often south of the 45th latitude, as compared with patients with non-Hodgkin's lymphoma or thyroid carcinoma (RR = 2.2 for
Results from previous research suggest that the ability to manage ambiguous problems during acute emergency and disaster management is a desirable quality among decision-makers. Ambiguity is a perception that arises when the problem-solver is dissatisfied with his or her understanding of the structure of the problem, and consequently of the problem-solving process. This article presents the result
CCK rapidly converted Ca2+/calmodulin kinase II (CaMK II) to a Ca(2+)-independent form with peak action at 30 sec followed by decline to the basal level at 10 min. The threshold concentration of CCK for this action was 30 pM and maximum effect occurred at 1 nM, which induced a 6-10-fold increase. Bombesin and carbachol similarly induced CaMK II autonomous activity, whereas secretin and JMV 180 did
Reliance on data for software systems engineering is increasing, e.g., to train machine learning applications. We foresee increasing costs for data collection and maintenance, leading to the risk of development budgets eaten up by commodity features, thus leaving little resources for differentiation and innovation. We therefore propose Open Collaborative Data (OCD) - a concept analogous to Open S
BACKGROUND: Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is the platelet counterpart of hemolytic disease of the newborn. Most severe cases of FNAIT are caused by antibodies against human platelet antigen-1a (HPA-1a). HPA-1a–negative women giving birth to an HPA-1a–positive child are at risk of becoming HPA-1a–immunized, particularly women who are HLA-DRB3*01:01–positive. The aim of the stud
Background: This preclinical study in humans was designed to selectively induce delayed nociceptive pain responses to individually titrated laser stimulation, enabling separate bedside intensity scoring of both immediate and delayed pain. Methods: Forty-four (fourteen female) healthy volunteers were subjected to repeated nociceptive dermal
In this reply to S. Durbin's comment on our original paper "Ultrafast terahertz-field-driven ionic response in ferroelectric BaTiO3," we concur that his final equations 8 and 9 more accurately describe the change in diffracted intensity as a function of Ti displacement. We also provide an alternative derivation based on an ensemble average over unit cells. The conclusions of the paper are unaffect
This article explains perceived loneliness among people in Europe by accounting for cultural factors as well as social isolation. Culturally, it measures the impact of both personal and societal individualism-collectivism on loneliness. It accounts for social isolation by looking at the separate effects of living alone, emotional isolation, and relational isolation. Using a 2014 European Social Su
The mechanism of how patatin-like phospholipase domain-containing protein 3 (PNPLA3) variant M148 is associated with increased risk of development of hepatic steatosis is still debated. Here, we propose a novel role of PNPLA3 as a key player during autophagosome formation in the process of lipophagy. A human hepatocyte cell line, HepG2 cells, expressing recombinant I148 or 148M, was used to study
Postprandial glycemic and insulinemic responses to variously processed red kidney beans were evaluated in normal subjects. The dried seeds were (a) boiled; (b) autoclaved; (c) boiled, freeze-dried, and milled to obtain a precooked flour (PCF) rich in cell-enclosed starch; or (d) milled, steam-cooked, and freezedried to yield a flour containing free starch (FSF). All bean products elicited lower me
OBJECTIVES. In clinical studies, it has been found that treating asthmatic patients with inhaled corticosteroids can reduce the need for in-patient care. The purpose of this study was to determine if such a relationship could be observed in available health-care statistics in Sweden and, if such a relationship could be established, what health economic consequences it implied. METHODS. A retrospec
Background: Chronological age is a key clinical determinant ofaortic stiffness. Self-perceived age (SPA) is a strong predictor ofwell-being and long-term health. We aimed to investigate theassociation between SPA, chronological age, and aortic stiffness(vascular ageing) in the general population.Methods: Cross-sectional analysis of a population-based study,Malmö Offspring Study (n=3563). Mean age
Purpose: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Despite the best available treatment, prognosis remains poor. Current standard therapy consists of surgical removal of the tumor followed by radiotherapy and chemotherapy with the alkylating agent temozolomide (TMZ). Experimental studies suggest that antisecretory factor (AF), an endogenous protein with propose
For two-component composites, we address the inverse problem of estimating the structural parameters and decrease measurement errors in bulk property measurements. A measurement of the effective permittivity at one frequency gives microstructural information about the composite that is used in cross-property bounds to estimate the effective permittivity at other frequencies. We use this informatio
