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It is well established that adaptive immune responses induced by hypercholesterolemia play an important role in the development of atherosclerosis, but the pathways involved remain to be fully characterized. In the present study we assessed immune responses to hypercholesterolemia induced by feeding Apoe-/- mice a high-fat diet for 4 or 8 weeks.
Rationale: Long-term outcomes after acute kidney injury (AKI) are poorly described. Objectives: We hypothesized that one single episode of minimal (stage 1) AKI is associated with reduced long-term survival compared with no AKI after recovery from critical illness. Methods: A prospective cohort of 2,010 intensive care unit (ICU) patients admitted to the ICU between years 2000 and 2009 at a provinc
Background Although childbearing is known to protect against breast cancer, whether or not breastfeeding contributes to this protective effect is unclear. Methods Individual data from 47 epidemiological studies in 30 countries that included information on breastfeeding patterns and other aspects of childbearing were collected, checked, and analysed centrally, for 50 302 women with invasive breas
De beslut vi tar idag och i framtiden avgör om världen går mot en tvågraders- eller en fyragradersvärld, eller någonting där emellan. Vertikal samverkan mellan politiska nivåer och horisontell samverkan mellan sektorer är viktig för att möjliggöra kostnadseffektiva ambitiösa utsläppsminskningar och åtgärder för klimatanpassning i Skåne. Arbetet med Klimatsamverkan Skåne och Strukturbild för Skån
Popular Abstract in Swedish Utvecklare i stora mjukvaruprojekt måste orientera sig i enorma informationslandskap. Brist på överblick innebär ett hårt slag mot produktiviteten. Mönster ifrån tidigare buggar kan guida framtida underhållsarbete.Software developers in large projects work in complex information landscapes and staying on top of all relevant software artifacts is an acknowledged challenge. As software systems often evolve over many years, a large number of issue reports is typically managed during the lifetime of a system, representing the units of work needed for its improvement, e.g., defects to fix, requested features, or
Collagen type II (CII) is a relevant joint-specific autoantigen in the pathogenesis of rheumatoid arthritis (RA). Whereas the reasons for the breakage of self tolerance to this major cartilage component are still enigmatic, T cell responses to glycosylated CII determinants in RA patients indicate that post-translational modifications play a role. Since the conversion of arginine into citrulline by
This work presents the quantum chemistry package MOLCAS, with emphasis on its usefulness as a platform for developing new quantum chemical codes, and the reader is assumed to be familiar with such a process. The development of new codes for quantum chemistry is a time-consuming job that can be dramatically simplified by using libraries for standard problems (such as calculation of integrals), and
Economic divisions have deepened in Sweden in recent years, and lone mothers are one group where the poverty rate has increased most (Salonen 2014). At the same time, di erences between the situations of lone mothers have also increased (Lundqvist 2014). As a consequence, intergenerational support from grandparents in terms of care and nancial transfers are important (see also Halleröd 2008). Th
Purpose: The purpose of the study was to identify serum microRNAs providing a link between male subfertility and metabolic syndrome (MetS) and validate their diagnostic potential. Methods: Sera were analyzed for fertility and MetS-related parameters in subfertile men (n = 79) and controls (n = 38). Literature review identified miR-155-5p, miR-122-5p, miR-200a-3p, and miR-200c-3p which previously w
To examine and compare the diagnostic accuracy of retinal nerve fibre layer (RNFL) thickness measurements using different Stratus optical coherence tomography (OCT) scanning protocols. Stratus OCT data for 90 healthy subjects and 62 glaucoma patients with mild or moderate visual field loss were prospectively collected and analysed using four RNFL thickness protocols that differed in terms of image
PURPOSE Cancer of unknown primary (CUP) is diagnosed at the metastatic stage, and despite extensive diagnostic work-up, the primary tumor often remains unidentified. No data are available on familial clustering of CUP. We hypothesize that familial clustering of CUP with other cancers may be informative of the primary sites. PATIENTS AND METHODS A total of 35,168 patients with CUP were identified i
In recent years, application of ensemble models has been increased tremendously in various types of natural hazard assessment such as landslides and floods. However, application of this kind of robust models in groundwater potential mapping is relatively new. This study applied four data mining algorithms including AdaBoost, Bagging, generalized additive model (GAM), and Naive Bayes (NB) models to
Denna uppsats har för avsikt att se hur amerikansk krigsfilm porträtterar rättfärdigheten i invasionen av Irak 2003. Avsikten är att fånga argumentationen som förs i filmerna om rättfärdighetens varande sett ur ett amerikanskt perspektiv. Genom denna förståelse kan man skapa förståelse över hur dessa filmer färgar synen på kriget hos åskådarna. Tre produktioner har valts att studeras; Green Zone (
Ett kronvittnessystem, som innebär att en tilltalad genom angivelse av andra personers brottslighet kan få ett lindrigare straff, förekommer inte i det svenska rättsystemet. Syftet med denna uppsats är att, efter en komparation med Danmark, utreda om ett kronvittnessystem som strafflindringsgrund borde införas. Straffsystemets vägledande principer i både Danmark och Sverige är rättssäkerhet, legalThe legal system of Sweden does not contain a crown witness system. A crown witness system means that a defendant can get a penalty discount if he or she reveals other people's crimes so the police and the prosecutor can convict other criminals. The purpose of this essay is to investigate, after a comparison with Denmark, if Sweden should introduce a crown witness system as a possibility to ge
Outdoor climate has considerable impact on the indoor climate and it is therefore important to adapt the buildings to the climate. This thesis shows how to improve indoor climate in a climate which it is hot, dry in the summer and cold in the winter. My investigative unit is a middle class house in the town Baalbek in Lebanon and the purpose of the study is to come up with proposals on possible so
Background: Tumour necrosis factor (TNF) antagonists have proved effective as treatment against rheumatoid arthritis ( RA), but the unresolved issue of whether the use of anti-TNF therapy increases the already elevated risk of lymphoma in RA remains a concern. Methods: Using the Swedish Biologics Register (ARTIS), the Swedish Cancer Register, pre-existing RA cohorts and cross-linkage with other na
Chronic obstructive pulmonary disease (COPD) is associated with colonization by bacterial pathogens and repeated airway infections, leading to exacerbations and impaired lung function. The highly glycosylated mucins in the mucus lining the airways are an important part of the host defense against pathogens. However, mucus accumulation can contribute to COPD pathology. Here, we examined whether inf
