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Background: Amplification of 1q (amp(1q); ≥4 1q copies) has repeatedly been reported to predict a worse outcome in multiple myeloma (MM), whereas the impact of gain of 1q (gain(1q); three 1q copies) is less clear. Methods: We investigated survival of MM in relation to amp(1q) and gain(1q) by retrospectively analysing 346 consecutively newly diagnosed MM (NDMM) patients. Of these, 62 (18%) had amp(
AIMS: The aim of this study is to investigate how genetic variations in genes related to oxidative stress, intake of antioxidant vitamins, and any potential interactions between these factors affect the incidence of intact abdominal aortic aneurysm (AAA) and its rupture (rAAA), accounting for sex differences where possible.METHODS AND RESULTS: The present retrospective cohort study (n = 25 252) us
Objective: To investigate long-term survival, neurologic outcome, and quality of life in patients with spontaneous supratentorial intracerebral hemorrhage (ICH) treated with craniotomy and hematoma evacuation. Methods: A nationwide multicenter retrospective analysis of 341 patients who underwent craniotomy and evacuation of supratentorial ICH between January 1, 2011, and December 31, 2015, was per
The article intervenes in discussions on lay knowledge production about health in the Internet era, through the case of a group of women claiming that their use of copper intrauterine devices has led to systemic side effects. Based on online group interviews and written essays, we examine how women embracing these knowledge claims navigate various sources of information, focusing on the role of sc
Background The prevalence of mental health issues is rising, especially among youth. Research shows that diagnosable and subthreshold mood disorder symptoms are increasing. Notably, and particularly troublesome, there are indications that some mental health issues, such as non-suicidal self-injury (NSSI) and disordered eating (DE) behaviors, have increased during the last decades, these reports, h
The authors develop a methodology to create databases that can be used to add micro-level geographic context to longitudinal historical demographic analyses. The method transforms geographic objects as snapshots (digitized from historical maps) into temporal representations of longitudinal object lifelines and links individuals to these geographic objects. The methodology is evaluated via a case s
Objectives: To describe the survival rate in a cohort of systemic sclerosis (SSc) patients with pulmonary arterial hypertension (PAH) and to evaluate possible predictors for SSc-PAH in a cohort of SSc patients. Methods: Thirty patients with SSc-PAH and 150 SSc patients without PAH were included. Survival and survival on therapy were calculated. Clinical features at baseline were correlated to the
The thesis deals with which legal basis seems appropriate to use when the purpose of the data controller is to carry out direct marketing. When processing personal data, the Controller must comply with the principles set out in Article 5 of the GDPR. One of the principles, the Principe of Lawfulness, requires the Processing to be supported on a legal basis in Article 6 of the GDPR. It is stated th
Opiate substitution treatment (OST) programs could provide opportunities for management of comorbidities, such as hepatitis C virus (HCV) infection, in people who inject drugs. We aimed to prospectively evaluate the real-life feasibility of interferon/ribavirin-based HCV treatment in OST recipients, with a special focus on psychiatric status and health-related quality of life.
The aim of this study was to describe the prevalence of falls in a general older population, especially among the most elderly, and the risk markers associated with falls.
In this report, a long-term study of the chloride environment around a highway exposed to severe de-icing is presented. The aim of the study was to obtain data that might be used for predictions of chloride ingress in de-iced structures and thereby provide necessary input to models for service life prediction.
AimsTo examine determinants for glycaemic control in primary care patients with Type 2 diabetes. MethodsIn a community-based surveillance of primary care patients with Type 2 diabetes, 190 men and 186 women were consecutively identified and examined for cardiovascular risk factors. Insulin resistance and beta-cell function were estimated using homeostasis model assessment (HOMA). Good glycaemic c
