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Investigating Circularity for Organic Waste Management: An Exploratory Single Case Study at Averda in Cape Town

As climate change and unsustainable waste practices present major global challenges, effective waste management in developing countries becomes critically important. In South Africa, organic waste constitutes a significant share of general waste and is often landfilled, contributing to methane emissions and serious health risks for the population. In response, the Western Cape province has introdu

If We Build It, Will They Come? An Infrastructural Perspective on Evaluations of Digital Data Reuse in Archaeology

The growing use of digital tools in archaeological practice has led to a proliferation of data. Concerns regarding how to best manage and store these significant volumes of archaeological data have been addressed by the development of digital research data infrastructures which function to ensure the long-term preservation of archaeological information and make it available for reuse. Recent Open

Batterilager i flerbostadshus: Kunskapsunderlag för investeringsbedömningar

Solpaneler på taket är numera en vanlig syn, men vart tar elen vägen när solen skiner som mest? I detta examensarbete har det undersökts hur flerbostadshus kan använda egna batterier för att spara pengar, bli mer självförsörjande och samtidigt stötta elsystemet. Svaret är att batterier kan löna sig, om de används smart. När elnätet blir allt mer pressat och produktionen från förnybar energi varier

Identifying genetic variants associated with sugar intake and appraising the genetic correlations with cardiovascular outcomes

BACKGROUND: The evidence linking sugar intake to cardiovascular disease risk remains largely inconclusive, with variations observed across different subgroups of sugar intake. In addition, studies on genetic markers of sugar intake are scarce, especially for different sugar subgroups.OBJECTIVE: This genome-wide association study (GWAS) aimed to investigate genetic variants associated with the inta

The prospective association between high-density lipoprotein (HDL) cholesterol and risk of incident fractures in the general population

SummaryElevated HDL-C levels are generally regarded as prognostically favorable in cardiovascular disease. Our study shows that higher HDL cholesterol levels are prospectively associated with 18% increased risk of new-onset fractures in men but not in women. Higher HDL cholesterol may be a novel risk factor for developing fractures in men.PurposeIncreased high-density lipoprotein cholesterol (HDL-

Per- and polyfluoroalkyl substances exposure in hexavalent chromium exposed workers and the effects of exposure mixtures on oxidative stress and genomic instability

Hexavalent chromium (Cr(VI)) can induce oxidative stress, genomic instability, and epigenetic modifications. In occupational settings, Cr(VI)-exposed workers may also be exposed to other toxicants, such as elements besides Cr, and per- and polyfluoroalkyl substances (PFAS). However, research on the extent of these co-exposures and their combined effects remains limited. The objective of this study

Migratory and wintering behaviour of the Baltic Lesser Black-backed Gull (Larus fuscus fuscus)

GPS tracking technologies are essential to follow long-distance migratory species throughout their annual cycle and identify the threats they encounter at large geographical scales. Information on the “lost” years of juvenile individuals of many species is lacking and it is vital to uncover their movements during these critical early stages. The Baltic Lesser Black-backed Gull (L. f. fuscus), a lo

Locus of control and breathlessness : a cross-sectional analysis of 28 730 people

Background Long-term pathological breathlessness is a life-limiting symptom that risks taking control of the individual’s life. We aimed to evaluate how locus of control (LOC), an individual’s perceived control of present and past life events, relates to breathlessness in a middle-aged general population. Methods A population-based, cross-sectional analysis of people aged 50–64 years was conducted

Characteristics of short REM sleepers and long-term CPAP use in the RICCADSA cohort

Study objectives: The impact of rapid eye movement (REM) sleep duration on long-term adherence to continuous positive airway pressure (CPAP) therapy in patients with obstructive sleep apnea (OSA) is unclear. This study aimed to assess the characteristics of individuals with short REM sleep and investigate whether reduced REM sleep is associated with lower CPAP adherence over a two-year period in t

Bone shape changes over two years following acute anterior cruciate ligament injury: Reconstructed vs non-reconstructed knees

Objective: To determine bone shape changes over two years after acute anterior cruciate ligament (ACL) injury and to compare knees treated with ACL reconstruction (ACLR) vs no ACLR. Design: We used prospective data involving 129 young adults (46 ​% female, mean age 25 years) with recent ACL injury from a subcohort within the prospective multicenter NACOX study. Patients were treated according to S

A simplified clinical frailty scale predicts mortality in emergency department patients with acute dyspnea

To evaluate a simplified version of the Clinical Frailty Scale (SCFS) among older adults presenting to the emergency department (ED) with acute dyspnea. In this retrospective single-center cohort study, we included patients from the Acute Dyspnea Study (ADYS) cohort. Severity of illness was assessed using the Medical Emergency Triage and Treatment System (METTS). SCFS was operationalized using exi

Postoperative complications in Hartmann's procedure versus intersphincteric abdominoperineal excision in rectal cancer : randomized clinical trial (HAPIrect)

Background: In patients with rectal cancer, when it is not possible to restore bowel continuity with an anastomosis, the optimal surgical method is still a matter of debate. The aim of this trial was to determine 30-day postoperative surgical complication rates after Hartmann’s procedure (HP) versus intersphincteric abdominoperineal excision (iAPE) in patients with rectal cancer who were not suita

Rapid shifts in bryophyte phenology revealed by airborne eDNA

Bryophytes constitute a diverse plant group with important roles in ecosystem functioning, in particular in arctic and subarctic environments. As they are physiologically strongly dependent on climatic conditions bryophytes could serve as indicators of ongoing climatic change. Their spores are generally dispersed by wind, and because of contrasting phenologies among species, the composition of the

BVOC and speciated monoterpene concentrations and fluxes at a Scandinavian boreal forest

Boreal forests emit terpenoid biogenic volatile organic compounds (BVOCs) that significantly affect atmospheric chemistry. Our understanding of the variation of BVOC species emitted from boreal ecosystems is based on relatively few datasets, especially at the ecosystem-level. We conducted measurements to obtain BVOC flux observations above the boreal forest at the ICOS (Integrated Carbon Observati

Profiling Associations Between IGHG-FCGR Ligand-Receptor Interactions and Disease Progression From Stage 1 and 2 to Stage 3 Type 1 Diabetes

UNLABELLED: The primary objective of this study was to investigate whether ligand-receptor interactions (LRIs) between IGHG and FCGR gene products are associated with progression to type 1 diabetes (T1D). Using two completed clinical trials (DPT-1 and TN07), we applied next-generation targeted sequencing to genotype IGHG and FCGR genes in a cohort of 1,214 individuals and assessed LRI associations

Latitude-specific responses of European birds' population growth rates to temperature and water availability

Climate limits distribution of species and shows considerable regional variability. However, studies relating climate variation to species population growth rates in different climatic zones while accounting for species' ecological traits are scarce. We assessed species population responses to the main climatic constraints at a continental scale by studying how precipitation and temperature at dif

Clinical Performance of the Elecsys CSF pTau181/Aβ42 Ratio for Concordance with Tau-PET in Two Independent Cohorts

Introduction: Amyloid- and tau-positron emission tomography (PET) are promising modalities for detecting pathological changes associated with Alzheimer’s disease (AD); however, their application is limited. Although the use of cerebrospinal fluid (CSF) biomarkers as alternatives to amyloid-PET and tau-PET has been explored, no in vitro diagnostic-approved or commercial CSF biomarker assays are cur