Sökresultat

Filtyp

Din sökning på "swedish" gav 92172 sökträffar

Mirror, mirror on the wall, who's the innovator after all? : An explorative study of a management-initiated employee innovation process

Today, the innovation arena is open to a wider range of participants than previously acknowledged. One specifically neglected group of innovators in traditional innovation studies is non-R&D and non-managerial employees, also referred to as ‘ordinary’ employees by the existing body of literature on employee-driven innovation (EDI). These employees have no formal innovation function, meaning th

Peer Assisted Study Sessions (SI-PASS) in Higher Education, a European overview

The paper/presentation gives an overview of Peer-Assisted Study Schemes (SI-PASS) in Higher Education in Europe. SI-PASS is a method of improving student performance in “difficult” courses combining “how to learn” with “what to learn”. SI-PASS sessions are scheduled parallel to the regular education and are guided and facilitated by a “senior” student, the SI-PASS leader. The sessions are based on

Glucagon Counter-Regulation to Hypoglycemia During Incretin-Based Therapy

Incretin-based therapy is associated with low risk of hypoglycemia in type 2 diabetes mellitus (T2DM) possibly due to its glucose-dependency in stimulating insulin secretion and a sustained glucagon response during hypoglycemia. This is of special relevance when it is combined with insulin or given to elderly patients since both insulin therapy and high age are associated with impaired glucagon co

Effect of tailored dose-dense chemotherapy vs standard 3-weekly adjuvant chemotherapy on recurrence-free survival among women with high-risk early breast cancer : A randomized clinical trial

IMPORTANCE Standard dosing of chemotherapy based on body surface area results in marked interpatient variation in pharmacokinetics, toxic effects, and efficacy.Whether tailored dosing can improve outcomes is unknown, as is the role of dose-dense adjuvant chemotherapy. OBJECTIVE To determine whether tailored dose-dense adjuvant chemotherapy improves the outcomes of early breast cancer compared with

Worldwide trends in diabetes since 1980 : A pooled analysis of 751 population-based studies with 4.4 million participants

Background: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults with d

Changes in prevalence of obesity and high waist circumference over four years across European regions : the European male ageing study (EMAS)

Diversity in lifestyles and socioeconomic status among European populations, and recent socio-political and economic changes in transitional countries, may affect changes in adiposity. We aimed to determine whether change in the prevalence of obesity varies between the socio-politically transitional North-East European (Łódź, Poland; Szeged, Hungary; Tartu, Estonia), and the non-transitional Medit

Web design for cognitive accessibility

Information and communication are increasingly being conveyed over the Internet. The forms of service and commerce that we are familiar with today will most likely be reduced in scale in the future to be replaced by new electronic solutions. For this reason, it is important that new technology be designed so that as many people as possible can utilize it. Accessibility to a range of services and i

Transitions Towards an Unknown Future: Non-Formal Learning in Transnational Communities for a Sustainable Society

The study makes an inventory of learning opportunities young people were offered in connection with CEI 2016, one of the annual international conferences organized by the NGO named Caretakers of the Environment International (CEI), which year 2016 took place in Aalborg in Denmark. The learning opportunities offered by this transnational learning community are discussed in relation to some essentia

Discriminative accuracy of [18F]flortaucipir positron emission tomography for Alzheimer disease vs other neurodegenerative disorders

IMPORTANCE The positron emission tomography (PET) tracer [18F]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of Alzheimer disease (AD), but its diagnostic utility is unclear. OBJECTIVE To examine the discriminative accuracy of [18F]flortaucipir for AD vs non-AD neurodegenerative disorders. DESIGN, SETTING, AND PARTICIPANTS In this cross-

Metodutveckling för att studera allmänhetens respons på energieffektiv utomhusbelysning

Artificial outdoor lighting for pedestrians should provide for a safe and secure outdoor environment after dark. Pedestrian lighting thereby has implications for active transportation and sustainable mobility. Installations of new energy efficient lighting applications should be evaluated in terms of pedestrian’s perception, evaluation and behaviour in the lit environment. Today there is a lack of

The Role of Maf Transcription Factors in Islet Inflammation and Βeta Cell Function

Endocrine disorders that lead to a state of chronic high blood glucose levels are collectively referred to as diabetes. This metabolic disease is mainly categorized into type 1 (T1D) and type 2 diabetes (T2D). These diabetic forms originate from distinct triggering environmental, genetic, and altered mechanisms. T2D is a consequence of metabolic load, peripheral insulin resistance, and failure of

Population-based studies of atrial fibrillation and ischemic stroke

AbstractBackground: Atrial fibrillation (AF) is a major risk factor for ischemic stroke and the most common cause of cardioembolic stroke. Early detection of AF and AF subjects at high risk for stroke is therefore important. Beyond traditional strong risk factors, such as high age and hypertension, the improvement of risk prediction with existing risk scores, is modest for most other risk markers.

Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice

AIMS/HYPOTHESIS: Obesity during pregnancy increases offspring type 2 diabetes risk. Given that nearly half of women of child-bearing age in many populations are currently overweight/obese, it is key that we improve our understanding of the impact of the in utero/early life environment on offspring islet function. Whilst a number of experimental studies have examined the effect of maternal obesity

Persistent organic pollutants, pre-pregnancy use of combined oral contraceptives, age, and time-to-pregnancy in the SELMA cohort

BACKGROUND: We are exposed to several chemicals such as persistent organic pollutants (POPs) in our everyday lives. Prior evidence has suggested that POPs may have adverse effects on reproductive function by disrupting hormone synthesis and metabolism. While there is age-related decline of fertility, the use of hormonal combined oral contraceptives (COCs) and its association to return of fertility

Cardiovascular organ damage in type 2 diabetes mellitus : The role of lipids and inflammation

Background: The relationship between dyslipidemia, inflammation and CV organ damage in type 2 diabetes mellitus (T2DM) is complex. Insulin resistance and inflammatory cytokines interleukins (ILs) increase plasma triglycerides (TG). ILs also up-regulate expression of matrix-metalloproteinases (MMPs) that, together with TG, decrease high density lipoprotein cholesterol (HDL) levels. High TG, low HDL

Prevention of Pancreatic β-Cell Failure in Type 2 Diabetes. By Targeting a Mitochondrial Voltage Gated Channel 1 and a Novel class of GPCRs.

It has been long known that hyperglycaemia-induced β-cell dysfunction precipitates type 2 diabetes (T2D) in insulin-resistant obesity, although the underlying mechanisms are still poorly defined. The few frequently used antidiabetic drugs on the market have still not satisfactorily demonstrated any long-lasting improvements of β-cell function and prevention of the disease. Islets synthesise and se

Using templates to support the engineering designer performing computer-based design analysis

In their quest for a more efficient and effective utilization of the resources allocated to engineering design projects, and thus to the overall product development project from which the current design task(s) originate, an increasing number of companies allow engineering designers to perform Computer-Based Design Analysis (CBDA) on their own – CBDA is here confined to quantitative analyses using

CFTR in pancreatic islets

AbstractCystic fibrosis (CF) is caused by mutations in the anion channel and protein regulator CFTR. The most common co-morbidity in CF is CF-related diabetes (CFRD) affecting ~50% of adult patients. The etiopathology of CFRD is largely unknown but the destruction of the exocrine pancreas is thought to contribute. However, the hypothesis that CFTR has a direct role in the endocrine pancreas has no

P-T evolotion and High-temperature deformation of Precambrian eclogite, Sveconorwegian orogen

Bergskedjor är uppbyggda av olika slags berggrund som skjutits samman i de zoner på Jorden där tektoniska plattor möts (konvergerar). Sådana processer sker i dag exempelvis i Himalaya, Alperna eller Anderna, men det finns också gamla, nu inaktiva, bergskedjor som de Skandinaviska Kaledoniderna (ca 400 miljoner år gammal) eller den Svekonorvegiska bergskedjan (ca 1000 miljoner år gammal, i sydvästr