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Tissue kallikrein releases pharmacollogically highly active kinins from kininogen. Many other enzymes may also release kinins. The aim of the study was to clarify the pathophysiological role of tissue kallikrein in acute pancreatitis. Two sensitive and specific radioimmunoassays for porcine and human tissue kallikrein were developed. A large release of tissue kallikrein from the pancreatic gland
Agricultural intensification has caused severe declines among biodiversity in European farmland over the last half century. The transformation of the agricultural landscape has led to reduced availability of key resources such as food, nesting habitat and shelter. In this thesis I have investigated a way of ameliorating the negative effects of agricultural intensification, through the creation of
Objective: To investigate the role of magnetic resonance imaging (MRI), assessment of bone mineral density (BMD) and antibodies to citrullinated proteins (anti-CCP) in predicting radiologic outcome in patients with early rheumatoid arthritis (RA). Patients: All patients were included in the BARFOT programme (baseline). The patients had rheumatoid arthritis of recent onset with mean disease duratio
Medicin | Vattenhallen Science Center Skip to main content This site uses cookies to enhance the user experience. By continuing to use the site you agree that cookies are used according to our Cookie Policy (on the website of LTH) . Essential cookies These cookies are necessary for the website to function and cannot be turned off in our systems. These cookies do not store any personally identifiab
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Per- and polyfluorinated alkyl substances (PFAS) are chemicals that have gained attention during the last years. There are about 10,000 different PFAS compounds, and due to their unique chemical characteristics, PFAS has been used in a variety of industrial applications and household products since the 1950s. Today, concerns about their toxicity and persistence have led to the regulation and banni
This paper presents a novel approach to understanding violence in service encounters through a sociological lens, focusing specifically on micro-interactional violence. Traditionally, research on violence has focused on structural aspects, linking it to the capitalist system or viewing it as symbolic violence (Gordon & Zainuddin, 2020; Varman, 2010). This study, however, shifts the focus to th
This report aims to identify both barriers that hinder energy-efficient renovation of buildings and drivers enabling the implementation of energy and cost-effective renovation of buildings and energy supply systems at the district level.Fifteen success stories regarding barriers and drivers were analysed in the first step. These success stories consisted of projects from seven European countries (
The EMPOST-NET project studied a new phenomenon: networking across different public and private sectors of society towards the most important goal of today – sustainable development. Sustainability networks are of special importance within the field of tourism, which is among the largest industries of today’s world, yet its environmental and socio-cultural impacts are often given too little attent
The overall aim was to investigate chronic pain, quality of life and factors associated with pain as well as with quality of life among older people, aged 75 years and above. Further, the aim was to investigate the use of methods for pain management and their effects for those with pain and in need of help for daily living. Data were collected from a larger population study and in the first study
How to judge religions other than one's own when the means are lacking due to linguistic mobility? In the present thesis this question is mainly analysed in a Christian setting through a reading of the theologians Paul Knitter and Harold Netland. It is, however, claimed that the same question could be asked in other religious settings, also with regard to one's own tradition, and could be treated
Cultural and creative activities are today described as central to regional and urban development by politicians and governments. Creative city policies are often aiming at economic benefits for the city itself, and there are normative purposes with many research studies as well as projects undertaken (Eckardt 2005; Markusen and Gadwa 2010; Kovacs 2011). Creative city policy is often oriented towa
Hur vi väljer att organisera våra familjer har genomgått en radikal förändring sedan mitten av 1900-talet. Kärnfamiljen är visserligen fortfarande den vanligaste familjeformen, men den har i allt större utsträckning kommit att kompletteras med en rad icke-traditionella familje-konstellationer, bl.a. samkönade familjer. Den här utvecklingen har naturligtvis också påverkat hur vi lever och praktisHow we choose to organize our families has changed significantly since the mid-20th century. It might be true that the nuclear family remains the most common family form. However, it has to an increasing extent been accompanied by a number of non-traditional families, including same-sex families. Naturally, this development has also affected the way we live and how we practice family life. While
The fetoplacental circulation is a low pressure system with a high vascular prostacyclin to thromboxane (Pc/Tx)synthesis ratio. In intrauterin growth restriction (IUGR) and diabetes the prostanoid balance may be altered. AIMS: To investigate relationships between umbilicoplacental vascular prostanoid synthesis (by incubation of vessel samples), circulatory changes (by Doppler velocimetry of umbili
Insulin stimulation of rat adipocytes results in phosphorylation and activation of the cyclic nucleotide phosphodiesterase 3B (PDE3B), a key enzyme in the antilipolytic signalling pathway of this hormone. In this thesis, the site phosphorylated in PDE3B upon stimulation of rat adipocytes with insulin and/or the beta-adrenergic agonist, isoproterenol is identified. In addition, upstream components
A suicide attempt is the best known predictor of completed suicide. It has long been assumed that most suicide attempts are the results of stress. The aim of this thesis was to examine some stress related peptides and their relations to the hypothalamic pituitary adrenal (HPA) axis, diagnoses and temperament in a heterogeneous group of suicide attempters shortly after a suicide attempt and at foll
Hormone-sensitive lipase (HSL) is a key enzyme in adipose tissue that hydrolyses stored fat (triacylglycerol). The activity of HSL is under strict hormonal and neural control. Lipolytic agents, such as catecholamines, increase the cAMP levels, resulting in an activation of cAMP-dependent protein kinase (PKA), which in turn phosphorylates and activates HSL. This thesis describes the structural orga
Genteknik innebär både möjligheter och risker. Såväl möjligheterna som ris-kerna är så betydande att det rimligen inte går att negligera dem. Gentekniken kan eventuellt medföra jordbruk som är mindre beroende av bekämpningsmedel, livsmedelsproduktion i annars ofruktsamma områden och skapandet av basala livsmedel som hindrar vanligt förekommande näringsbrist inte minst i utvecklingsländer. Riskerna
