Filtyp
BACKGROUND: Pneumonia is a common infection that leads to frequent hospitalizations and primary healthcare visits. Previous smaller studies have indicated high prevalence of undiagnosed diabetes mellitus (DM) and increased subsequent risk of coronary heart disease (CHD) among patients with pneumonia. However, previous studies have not used nationwide data that include diagnoses from primary health
AbstractBackground:Multidrug-resistant Acinetobacter baumannii remains as a global concern with its ability to adhere, disperse and sustain on areas involving suboptimal infection control measures, especially war zones. We aimed to evaluate the molecular epidemiology and virulence factors of A. baumannii isolates from conflict zone in Ukraine.Methods:In 2022, 46 A. baumannii wound isolates were re
BackgroundGestational diabetes mellitus (GDM) is defined as glucose intolerance first recognized during pregnancy. Offspring of GDM mothers have an increased risk of developing type 2 diabetes (T2D), obesity, and other metabolic disorders later in life.MethodsWe analyzed metabolic, genetic, epigenetic, and transcriptional profiles in umbilical cord blood (UCB) from male and female offspring of GDM
Background: Cystic fibrosis (CF) is a multisystem genetic disease characterized by chronic airway infection and progressive lung function decline. With increasing life expectancy, extrapulmonary comorbidities such as cystic fibrosis–related diabetes (CFRD) and hepatobiliary involvement have become important contributors to disease burden in people with CF (pwCF). Aim: The overall aim of this thesi
Glucose‑dependent insulinotropic polypeptide (GIP) and glucagon‑like peptide‑1 (GLP‑1) regulate metabolism and are increasingly targeted in therapies for type 2 diabetes and obesity. Although GLP‑1 receptor agonists confer cardiovascular benefits, the cardiovascular effects of GIP receptor (GIPR) stimulation remain controversial. This study aimed at defining the short-term cardiovascular consequen
I den här studien utvärderar vi geologiska arkiv och ett flertal geologiska metoder för att identifiera och datera historiska stormflodshändelser längs Hallands kust. Vi har också undersökt en lokal vid Löderup i Skåne som påverkats av en modern stormflod under stormen Babet hösten 2023. Genom fjärranalysbaserat platsurval, fältarbete samt olika laboratorieanalyser inklusive dateringsmetoder testa
Background – Trastuzumab deruxtecan (T-DXd) is effective in HER2-expressing metastatic breast cancer (mBC), yet inter-patient benefit varies. The current reference biomarker—HER2 immunohistochemistry (IHC) on tumor biopsies—is insufficient as a sole predictor of response. HER2-targeted PET/CT offers non-invasive, whole-body, real-time assessment of target expression. We hypothesize that HER2-targe
Background: In coproduced research, competing priorities among researchers and partners often surface as the work progresses, making such processes rarely tension-free. Although coproduction approaches are increasingly used in mental health research, there is limited understanding of how tensions are managed and how this influences collaboration. Hence, the aim of the study is to explore how tensi
AIMS: Aging is a major risk factor for cardiovascular disease (CVD) and is also linked to a functional decline of the immune system. B cells contribute to atherosclerosis progression by antibody secretion, antigen presentation and T-cell regulation. During aging, CD11c+CD21low B cells accumulate, but it is unclear whether these age-associated B cells (ABCs) are linked with incident cardiovascular
Purpose: Proliferative diabetic retinopathy (PDR) is one of the leading causes of blindness in working-age adults. We have previously shown that the risk of PDR is significantly elevated in individuals with intrauterine exposure to famine. However, the genetic mechanisms mediating this association remain unknown. The aim of the current study was to investigate the molecular underpinnings of famine
Issuing a letter of intent often involves an initial step toward a contract, contemplating that a contract will be entered in the future. Agreements with the same meaning go under a variety of names. In the field of banking and finance a preliminary agreement is often referred to as a Commitment Letter. Traditionally, a letter of intent is a preliminary agreement without legal effects. However, so
Environmental Assessment is an assessment of the likely effects a project might have on the environment. The purpose of the assessment is to ensure that decision-makers consider environmental impacts before deciding whether to grant permission to new projects. The method originated in the United States in the 1960s and it can be defined as the process of identifying, predicting, evaluating and mit
Most bilateral tax treaties contain provisions with the objective of preventing different types of treaty abuse. Limitation on benefits clauses are an example of such provisions, and are generally found in United States tax treaties. These include various tests, which need to be fulfilled by a taxpayer wishing to enjoy the benefits of a tax treaty. Most of the United States tax treaties with EU Me
Trafficking for sexual purposes means that a person is being transported under slavery-like conditions from one place to another, this due to violence, misguidance or abuse, in order to later be abused sexually. Despite that article 4 in the UN declaration of human rights forbids slavery and slave trade, millions of women and children are seen as trade products and are forced into prostitution. In
Background Acute pyelonephritis is a common infection in adult women, but there is a paucity of controlled trials of its treatment and the optimum duration of antibiotic treatment has not been properly defined. We compared the efficacy of ciprofloxacin for 7 days and 14 days in women with community-acquired acute pyelonephritis. Methods In a prospective, non-inferiority trial undertaken at 21 cent
