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Perfluoroalkyl substances (PFAS) can act as surfactants and have been suggested to be capable of affecting gut mucosa integrity, a possible factor in the pathogenesis of inflammatory bowel disease (IBD). So far, only PFOA has been shown to have a positive association with ulcerative colitis. The present study aimed to investigate the association of PFAS and clinically diagnosed IBD in the Ronneby
In the name of transparency and accountability, numbers and statistics have gained importance as indicators of quality, effectiveness and efficiency of welfare services such as social work. It has been argued that the requirements to formalise how and on what grounds decisions are made have undermined the professional autonomy and discretion of social workers. These requests have arguably also led
BACKGROUND: Opioid-related deaths have increased in Western countries over recent decades. Despite numerous studies investigating opioid-related mortality, only a few have focused on the lives of the deceased individuals prior to their deaths, specifically regarding contact with care-providing authorities such as health, social and correctional services. Furthermore, a change has been noted in the
INTRODUCTION: Elevated levels of markers for thrombin activation are associated with plaque echogenicity and degree of stenosis in patients with carotid artery stenosis. The Activated Protein C-Protein C Inhibitor (APC-PCI) complex reflects activation of the Protein C system and is a measure of thrombin generation. The aim of the present study was to examine APC-PCI complex in patients undergoing
AIMS/HYPOTHESIS: The T allele of transcription factor 7-like 2 gene variant, TCF7L2 rs7903146, increases the risk of type 2 diabetes by 40-50%. As TCF7L2 rs7903146 has been associated with diminished incretin effect we investigated whether interaction between dietary intake of carbohydrate, fat, protein or fibre and this variant affects the risk of type 2 diabetes. METHODS: A cohort of 24,799
Background Chronic immune stimulation appears to be associated with lymphoplasmacytic lymphoma (LPL)-Waldenström macroglobulinemia (WM); however, available information is sparse. We conducted, to our knowledge, the most comprehensive study to date to evaluate associations between a personal or family history of many immune-related and/or inflammatory disorders and the subsequent risk of LPL-WM. Me
Background: Genetic polymorphisms associated with common aetiologically complex diseases have recently been identified through genome-wide association studies. Direct-to-consumer genetic testing for such polymorphisms, with provision of absolute genetic risk estimates, is marketed by several commercial companies. Polymorphisms associated with atrial fibrillation (AF) have shown relatively large r
BACKGROUND AND AIM: Many multilevel logistic regression analyses of "neighbourhood and health" focus on interpreting measures of associations (e.g., odds ratio, OR). In contrast, multilevel analysis of variance is rarely considered. We propose an original stepwise analytical approach that distinguishes between "specific" (measures of association) and "general" (measures of variance) contextual eff
Although pharmacological treatments can help alleviate mood symptoms in youth with paediatric bipolar disorder (PBD), residual symptoms still commonly persist. In many cases, these symptoms seriously affect the social and psychological development of children and adolescents suffering from PBD. Complementary interventions, such as psychosocial and psychoeducational treatments, can help children an
BACKGROUND: The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS: Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 human genes in up to 72,868 patients with coronary artery disease and 120,770 controls who did not have coronary artery disease. Through DNA sequ
Background: The time spent in nursing homes (NHs) by patients with Alzheimer’s disease (AD) might be influenced by many factors, e.g., sociodemographic and clinical characteristics, rate of disease progression, and concomitant disorders. Whether different aspects of cholinesterase inhibitor (ChEI) therapy (drug agent, dose, and duration) affect time spent in NHs has not been investigated. We studi
Background: Whether and how n-3 and n-6 polyunsaturated fatty acids (PUFAs) are related to type 2 diabetes (T2D) is debated. Objectively measured plasma PUFAs can help to clarify these associations. Methods and Findings: Plasma phospholipid PUFAs were measured by gas chromatography among 12,132 incident T2D cases and 15,919 subcohort participants in the European Prospective Investigation into Canc
Burkitt lymphoma (BL) is a rare, aggressive disorder constituting 1% of all non-Hodgkin lymphoma. Diffuse large B-cell lymphoma (DLBCL) is more common, accounting for 30% of malignant lymphoma. Standard treatment for adult BL and for certain subgroups of patients with DLBCL remains to be defined due to paucity of randomised trials performed. The focus in this thesis lies on the effect of prognosti
Kännetecknande för aktiebolagsformen är aktieägarnas avsaknad av personligt ansvar. Detta skapar även förutsättningar för en intressekonflikt mellan aktiebolagets ägare och dess borgenärer där synen på samt incitamenten till såväl investeringar som risktagande kan skilja sig åt. Kapitalskyddssystemet utgör en central del av det aktiebolagsrättsliga borgenärsskyddet och kan betraktas som lagstiftarThe limited liability company is characterised by the shareholders’ lack of personal liability. This also forms the basis of a conflict between the owners of the company and the creditors of the company, whose approaches and incentives for investments as well as risk-taking may diverge. The legal capital regime constitutets a core part of creditor protection under company law and can be considered
Självskadebeteende är ett alltmer vanligt förekommande fenomen bland unga och vård är i många fall essentiellt för att lindra problemet. Självskadebeteende kan uttrycka sig på olika vis, bland annat genom att den unge medvetet utsätter sig för riskfyllda sexuella situationer. Syftet med uppsatsen är att med rättsdogmatisk metod undersöka när självdestruktivt sex utgör en grund för vård enligt Self-harm is a growing problem in our society, especially among adolescents. The purpose of this essay is to investigate under which circumstances selfdestructive sex can be considered a reason for compulsory care according to 3 § Care of Young Persons Act, LVU. The current legal conditions will be explored as well as case law. Compulsory care is intended to provide help to young people whose
När ett avtal mellan en spökskrivare (upphovsman) och en uppdragsgivare (förvärvare) ingås angående överlåtelse av namngivningsrätt, aktualiseras en av de mer intrikata juridiska frågeställningarna som berör gränslandet mellan upphovsrätt och avtalsrätt. Vid en första anblick, med utgångspunkt i vad upphovsrättslagen stadgar, verkar det inte vara möjligt för en upphovsman att totalt överlåta sin r
Rätten till avdrag för ränteutgifter begränsas genom den generella och de riktade ränteavdragsbegränsningsreglerna, däribland undantagsregeln i 24 kap. 18 § andra stycket IL. Regeln gör undantag för avdragsrätt när ränta betalas på koncerninterna lån när sådana uppkommit uteslutande eller så gott som uteslutande för att koncernen ska erhålla en väsentlig skatteförmån. Ränteavdragsbegränsningarna sThe right to deduct interest expenses is limited by the general and targeted interest deduction limitation rules, including the “exemption rule” in Chapter 24, Paragraph 18, subparagraph 2 of the Law on income tax. This rule excludes the right to deduct interest paid on intra-group loans if such loans have been made exclusively or almost exclusively for the purpose of obtaining a substantial tax b
Aldrig före 2022 har demonstranter dömts för sabotage, trots att bestämmel-sen har funnits sedan 1948. Att straffansvar för sabotage nu dömts ut mot aktivister har väckt debatt om hur lagstiftningen egentligen ska tillämpas. Även ett konstitutionellt perspektiv aktualiseras, eftersom domstolen tillämpar strafflagstiftningen på en situation där den tilltalade utövar sin grundlagsskyd-dade demonstraPrior to 2022, protesters had never faced convictions for sabotage, despite the provision existing since 1948. The imposition of criminal liability for sabotage on activists has sparked a debate on how the legislation should be applied. A constitutional perspective is also highlighted, as the court applies criminal law to a situation where the defendant is exercising their constitutionally protect
