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Insulin secretion is coupled with changes in beta-cell metabolism. To define this process, 195 putative metabolites, mitochondrial respiration, NADP(+), NADPH and insulin secretion were measured within 15 mm of stimulation of clonal INS-1 832/13 beta-cells with glucose. Rapid responses in the major metabolic pathways of glucose occurred, involving several previously suggested metabolic coupling fa

Abstract/Results. The paper discusses the results of three different studies. A study of 717 ninth grade students in eight schools located in different socio-economic environments show that students have a low degree of trust in dispute settlement forms available at school. When involved in conflicts or degrading treatment at school they avoid turning to the school for help. Students give themselv

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at

Assays detecting antigen (Ag)-specific T-cell responses in immune-mediated processes are increasingly employed to understand disease pathogenesis and "immune staging". The quantity and quality of starting peripheral blood mononuclear cell (PBMC) preparations are important factors in the performance of such assays. We therefore compared final PBMC yield and function by modifying parameters at the b

ApolipoproteinA-I (ApoA-I) is the major protein component of high-density lipoprotein (HDL), and is critical for maintenance of cholesterol homeostasis. During reverse cholesterol transport, HDL transitions between an array of subclasses, differing in size and composition. This process requires ApoA-I to adapt to changes in the shape of the HDL particle, transiting from an apolipoprotein to a myri

More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only similar to 3% of the trait variance. Here we test two overlooked sources of variation in 192,974 European ancestry women: low-frequency proteincoding variants and X-chromosome variants. Five missense/nonsense variants (in ALMS1/LAMB2/TNRC6A/TACR3/PRKAG1) are asso

In order to meet the unprecedented challenge of feeding an increasing population while curbing associated environmental impacts a fundamental change in the current food system is required. Such a shift needs an active facilitator who could set and implement the sustainability agenda in the food supply chain. Recently, it has been argued that retailers might become a vital agent of change towards s

Load demand in residential houses is a significant contributor to peak load problems experienced by utilities. The knowledge about demand variation in households is fairly limited as well as the use of various tools to analyze the demand. Many utilities have recently installed interval (hourly) metering at their residential customers. The availability of hourly data is a significant progress, howe

Critical infrastructures provide society with services that are essential for its functioning and extensive disruptions of these give rise to large societal consequences. Vulnerability analysis gives important decision information concerning improving their ability to withstand strains. To analyze vulnerabilities in infrastructures models for estimating consequences due to failures are needed. Con

The impact of European Union law on the regional and local levels in the Member States has been underestimated for a long time now. Today, however, it is clear that the impact of European Union law on these levels is important, not least as a consequence of the deregulation that has been carried out in most Member States in recent years. As local markets open up for competition, the scope of EU la

It is important that the costs and effort in making a Virtual Reality (VR) model support its purpose in the specific context in which it is used. The present research aims to clarify which properties in VR-models contribute to improved experience of aspects of the model that are relevant in the use context and which therefore improve the models’ usability in the social processes of which they are

Concerns have been raised about the marketization of science through the prevailing funding regime. However, the present article will discuss how it comes that the potentially marketable stem cell science is not more commercialized than what is currently the case. We approach this question by analysing discursive pluralism in defining the value of stem cells within a grant allocation process. More

Today, the demand for shorter lead times, shorter production runs and more diversified products is a general market trend, which puts pressure on logistics systems. When adapting to this trend, agile manufacturing becomes increasingly important. Flexible printing activities, in particular, are needed when products and packaging designs increasingly are to be adapted for niche markets. This study s

The mid-Holocene Littorina Sea transgression has been studied in sediment cores from four coastal lakes in NW Russia. The basins are situated in the same drainage system at elevations from 6.9 to 9.2 m a.s.l. Complementary parameters have been applied to identify water-level changes. Chronological models are based on AMS radiocarbon dating of bulk sediments but also wood remains and moss sedge pea