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Space Syntax theory is a methodological framework for describing and analysing the relationships between spaces and buildings. The fundamental building blocks of Space Syntax are called axial lines, which represent lines of sight from a specific point in space. These lines can then be used to quantitatively analyse the integration (or attractiveness) of an area. However, many public squares and tr

Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains unknown. Here we show that conventional Par-4 knockout (Par-4-/-) mice and adipocyte-specific Par-4 knockout (AKO) mice, but not hepatocyte-specific Par-4 knockout mice, are obese with standard chow diet. Par-4-/- and AKO mice exhibit increased ab

Leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins have been implicated as regulators of growth factor signaling; however, the possible redundancy among mammalian LRIG1, LRIG2, and LRIG3 has hindered detailed elucidation of their physiological functions. Here, we show that Lrig-null mouse embryonic fibroblasts (MEFs) are deficient in adipogenesis and bone morphogenetic protein (B

Women tend to have lower interest in engineering as compared to men, which previous research has shown is partly explained by gender differences in self-efficacy, social belongingness and communal career goals. Therefore, to attract more women to engineering, effective interventions are needed that target these factors. In this study, we evaluated an industry-designed intervention for high school

Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which encodes a Janus kinase with critical roles in type-Ι interferon (IFN-Ι) mediated intracellular signalling. To study the role of TYK2 in β-cell development and response to IFNα, we generated TYK2 knockout human iPSCs and directed

Most cross-cultural studies on management control have compared Anglo-Saxon firms to Asian firms, leaving us with limited understanding of potential variations between developed Western societies. This study addresses differences and similarities in a wide variety of management control practices in Anglo-Saxon (Australia, English Canada), Germanic (Austria, non-Walloon Belgium, Germany) and Nordic

Objectives. The aim of this systematic review was to describe interventions which promote safe patient handling and movement (PHM) among workers in healthcare by reviewing the literature on their effectiveness for work and health-related outcomes. Methods. Databases were searched for studies published during 1997–2018. Measures were operationalized broadly, capturing outcomes of work and health. O

Backgroundamong the 1–1.5 billion persons with hypertension globally only, 20–30% have controlled blood pressure (BP). The most important problem identified is non-adherence to treatment, i.e., failure to change lifestyle and to take prescribed medication. Knowledge about the reasons for this is limited.ObjectivesThe aim of the study was to explore people's experiences of having hypertension.Desig

The presentation and underlying pathophysiology of type 2 diabetes (T2D) is complex and heterogeneous. Recent studies attempted to stratify T2D into distinct subgroups using data-driven approaches, but their clinical utility may be limited if categorical representations of complex phenotypes are suboptimal. We apply a soft-clustering (archetype) method to characterize newly diagnosed T2D based on

This report presents the findings from a pre-study concerning the opportunities and challenges of digitalization and automation in bridge design. The project approach is divided into three parts: 1) a short review of the relevant literature, 2) investigations concerning bridge industry perspectives (with focus on bridge consultants), and 3) the identification of future research needs based on part

Multi-nucleotide variants (MNVs), defined as two or more nearby variants existing on the same haplotype in an individual, are a clinically and biologically important class of genetic variation. However, existing tools typically do not accurately classify MNVs, and understanding of their mutational origins remains limited. Here, we systematically survey MNVs in 125,748 whole exomes and 15,708 whole

This article discusses the politics of “direct- action” against fossil fuels put forward by climate justice movements, focusing in particular on the tactic of the blockade. Drawing on the conceptual toolkit of Urban Political Ecology, the argument moves from a critique of the consensual regime of climate change governance to highlight conflict and dissent as central forces for the transformation o

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via mRNA targeting, playing important roles in the pancreatic islets. We aimed to identify molecular pathways and genomic regulatory regions associated with altered miRNA expression due to glycemic status, which could contribute to the development of type 2 diabetes (T2D). To this end, miRNAs were identified by a combinatio

Research on personality traits predicting life outcomes has typically been investigated using the Big Five factors and only occasionally their facets. However, recent research suggests that the use of items (reflecting personality nuances) can account for more predictive variance. The aim of the present study was to examine the predictive validity for various life outcomes comparing the hierarchic

This paper analyzes incomes and income inequality in Stockholm from 1870 to 1970. The paper builds on a new dataset of 38,022 randomly sampled Stockholm residents 1870–1950, with information on income, occupation, age, gender, and household composition. This is complemented by the Census of 1930 and a Statistics Sweden sample for 1960 and 1970. Incomes were very unequally distributed between 1870

In this article we discuss the notions of social sustainability and universal design by reflecting on a particular type of architectural element in common space, namely the “social staircases” that serve as multifunctional spaces beyond mere transportation, aiming at social interaction. Through empirical examples, including a detailed analysis of a newly built housing project in Sweden, renowned f

Walking and cycling are considered sustainable transport modes, promoted as a means to reduce car traffic. In the scientific literature, they have mostly been investigated separately, but should be considered jointly to enable a modal shift. Both daytime and dark conditions need to be studied, to improve understanding of how environmental features are affected by temporal variation. A conceptual m

Positive teacher-student and student-student relationships are among the most significant factors contributing to learning, motivation, wellbeing, and graduation rates in higher education. Trust is commonly understood as a key element for the development and sustenance of positive educational relationships, yet relatively little empirical research investigates trust in higher education classrooms.