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Growing concern about airborne particles in indoor environments requires fast source identification in order to apply remedial actions. A methodology for identifying sources emitting particles larger than 0.5 mu m was designed and applied. It includes: (1) visual inspection of interior surfaces in order to identify deposited particles and inspection of potential sources (equipment, materials. acti
Background: Although research has found that temperament and social support are associated with depression, these relationships have not been explored in conjunction with one another as they relate to depression using a genetically informative design. This study investigated how the association among the three constructs is mediated. Methods: The sample in this study consisted of 326 pairs of adul
This article is based on the Agent-action-Objective (AaO) axiom and assumes that intention can be discovered and made evident. But this requirement can be satisfied only under the condition that a particular individual can be identified with his style of writing. This implies that the nature of writing becomes approachable. Getting a style under control presupposes the A-component, which is discus
Despite having the same snowmelt processes, snowpacks in urban environments experience a range of conditions different from those of rural areas. Melt is intensified at some sites due to greater radiative energy. Shading, however, can reduce radiation and melt at other sites. Changes to the radiation balance and snowpack processes have been investigated. A physical snowpack model was developed and
High and low density lipoproteins (HDL and LDL) are thought to play vital roles in the onset and development of atherosclerosis; the biggest killer in the western world. Key issues of initial lipoprotein (LP) interactions at cellular membranes need to be addressed including LP deposition and lipid exchange. Here we present a protocol for monitoring the in situ kinetics of lipoprotein deposition an
An amperometric immunoanalysis system based on monoclonal antibodies immobilized on Sepharose beads and packed into a micro-immunocolumn was developed for the quantification of microcystin-LR. Microcystin-LR (MCLR) was used as a reference microcystin variant. Inside the immunocolumn, free microcystins and microcystin-horseradish peroxidase (tracer) were sequentially captured by the immobilized ant
A potentially useful approach for drug discovery is to connect gene expression profiles of disease-affected tissues ("disease signatures") to drug signatures, but it remains to be shown whether it can be used to identify clinically relevant treatment options. We analyzed coexpression networks and genetic data to identify a disease signature for type 2 diabetes in liver tissue. By interrogating a l
Vid kronisk myeloisk leukemi har målstyrd, kontinuerlig behandling med tyrosinkinashämmare lett till dramatiskt förbättrad överlevnad. Efter ett flertal år uppnås djupt molekylärt svar hos ca 50 procent av patienterna; ca 50 procent av dem kan då avbryta behandlingen utan tecken på återfall. Kontinuerlig behandling med tyrosinkinashämmare kan ge långsiktiga biverkningar. Efter patentutgång för imaChronic myeloid leukemia - a model disease for targeted therapy Chronic myeloid leukemia (CML) pioneered as the first human malignancy linked to a specific cytogenetic aberration (the Philadelphia chromosome), which led the way to specific targeted therapies with imatinib (Glivec) and later tyrosine kinase inhibitors (TKI). Continuous TKI administration, blocking the oncogenic fusion protein Bcr-A
Unbiased, “nontargeted” metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful applications to human disease. By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent biomarker of CT-defined nonalcoholic fatty liver disease (NAFL
Walking as a means of transportation is a key feature in sustainable urban design, but few studies have examined the influence of micro-level environmental features, such as vegetation and street lighting, on perceived safety and people’s choice to walk. This study applied a non-explicit approach to examine the relationship between greenery, street lighting, perceived safety, and walking in an urb
