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Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study

Aims The Environmental Determinants of Diabetes in the Young planned biomarker discovery studies on longitudinal samples for persistent confirmed islet cell autoantibodies and type 1 diabetes using dietary biomarkers, metabolomics, microbiome/viral metagenomics and gene expression. Methods This article describes the details of planning The Environmental Determinants of Diabetes in the Young biomar

Identification of a NK/T cell restricted progenitor in adult bone marrow contributing to bone marrow and thymic-dependent NK cells.

Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restriction of multipotent progenitors might take place already in the BM, we tested the

Bisexuals in relationships: uncoupling intimacy from ontology

A dominant notion that homosexuality and heterosexuality give meaning to bisexuality already exists. But no one has explored the meaning that bisexuality might accrue with regard to monosexuality. Because bisexuals were never fully recognized within queer theory, the homosexual-heterosexual binary opposition continues to be the primary understanding of difference. Further, within queer theory, the

What does not move any hearts – why should it be saved? The Denkmalpflegediskussion in Germany.

This paper is about the recent discussions (known as Denkmalpflegediskussion) on the principles and practices of state heritage management in Germany. In an expert report commissioned by the prominent German politician Antje Vollmer from Dieter Hoffmann-Axthelm, a number of fundamental criticisms were made. They concern existing practices of state heritage management, some of which are said to ali

Productivity, vitality and utility in a group of healthy professionally active individuals with nocturia

OBJECTIVES To assess the effect of nocturia on productivity, vitality and utility in a selected group of professionally active individuals with nocturia, compared with matched controls, and investigate the effect of symptom severity, to test the hypothesis that lack of sleep caused by frequent sleep interruptions could reduce an individuals' daytime energy and activity levels. SUBJECTS AND METHODS

Participation in Green Consumer Policies: Deliberative Democracy under the Wrong Conditions?

In policy debates about reducing environmental and social harms, political consumerism is often called for by actors from a broad political spectrum. This paper examines traits of deliberative democracy in cases where instruments of political consumerism (eco-labelling, certificates and standards) are developed. The empirical cases are processes surrounding eco-labelled, standardised forestry, foo