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The gut microbiota is associated with human health and disease. Here we conducted a genome-wide association study of host genetic factors influencing gut microbiota composition in 12,652 individuals from the Trøndelag Health Study (HUNT), with replication in Nordic cohorts (n = 16,017–21,976). We identified 12 reproducible SNP–species associations across six genomic loci, including known (LCT, ABO

Somatostatin, produced by pancreatic islet δ cells, is a key intra-islet paracrine factor that regulates the secretion of the glucoregulatory hormones insulin and glucagon from β cells and α cells, respectively. Here, we show that glutamate and glucagon released by α cells cooperatively activate neighbouring δ cells through AMPA and glucagon receptors, thereby enabling spatiotemporal feedback cont

Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Braz

In Norwegian, a weak quantifier or a scalar adjective with a positive value may combine with a definite noun and thereby form an attenuating NPI. These phrases, which I call predicative definite NPIs, are exceptional as nominal phrases, since they do not accept a prenominal definiteness marker despite their overall definiteness, and they are exceptional as attenuating NPIs, since they are templati

OBJECTIVE : To identify predictors of later study withdrawal among participants active in The Environmental Determinants of Diabetes in the Young (TEDDY) for 1 year. METHODS : Multiple logistic regression was used to discriminate 3,042 children active in TEDDY for the first 3 years from 432 children who withdrew in Years 2 or 3. Predictor variables were tested in blocks-demographic, maternal lifes

This experimental study adapts a usage-based perspective on L2 acquisition (Bybee 2008; Ellis 2008) and focuses on the production of French subject-verb (SV) agreement in number (singular vs. plural). Previous studies show that the acquisition of this agreement is a long and gradual process in L2 French (Bartning & Schlyter 2004; Prévost 2009; Michot 2015). This study examines the influence of

The lack of treatments during the recent Ebola and Zika outbreaks dramatically exposed the vulnerability of the global health system and the dire consequences thereof. But even where therapies against infectious diseases had been available, an additional threat has gained world-wide attention: antimicrobial resistance (AMR). A growing number of microbial organisms are becoming resistant to availab

Förevarande framställning avhandlar Lagrådet och dess granskningsverksamhet. De lagförslag som utformats i enlighet med Lagrådets rekommendation håller en mycket hög kvalité. Lagstiftningen blir precis, enhetlig, förenlig med gällande rätt och med de rättsstatliga principerna. Förslaget till en ny läkemedelslag utgör ett exempel på lagstiftning som gjorts förenlig med gällande rätt, närmare bestä

Uppsatsens övergripande syfte är att strukturera och systematisera hur svensk rätt hanterar bodelningsavtal som har ingåtts på felaktiga antaganden. Ett bodelningsavtal är en produkt av två rättsområden: familjerätten och förmögenhetsrätten. Familjerätten tillhör privaträtten och innehåller regler som styr enskilda individers privatliv. Förmögenhetsrätten handlar om ekonomi och hur enskilda indivi

Consumer goods can be delivered in a number of different ways. One important and very interesting method is the use of e-commerce to deliver the groceries to the consumer. Distribution of consumer goods, especially groceries, poses a number of challenges to the use of e-commerce. Challenges that must be solved in order to find a justified solution. This paper will present and discuss a new researc