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Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in
Osteocytes have recently been identified as a new regulator of bone remodeling, but the detailed mechanism of their differentiation from osteoblasts remains unclear. The purpose of this study is to identify cell cycle regulators involved in the differentiation of osteoblasts into osteocytes and determine their physiological significance. The study uses IDG-SW3 cells as a model for the differentiat
Cosmology presents students with ideas that stimulate their curiosity and brings together various concepts from STEM that call on a variety of reasoning types across multiple representational modes, involving subtleties of spacetime relations, a variety of models and evidence requiring multiple lines of high precision observations. This study investigated high school students’ levels and types of
Understanding the impact of various factors on train arrival delays is a prerequisite for effectiverailway traffic operating control and management. Existing studies analyze the train delayfactors using a single, generic regression equation, restricting their capability in accounting forheterogeneous impacts of spatiotemporal factors on arrival delays as the train travels along itsroute. The paper
Understanding the impact of various factors on train arrival delays is a prerequisite for effective railway traffic operating control andmanagement. Existing studies model the train delay prediction problems using a single, generic equation, restricting their capabilityin accounting for heterogeneous impacts of spatiotemporal factors on arrival delays as the train travels along its route. The pape
The extent to which increased liver fat content influences differences in circulating metabolites and/or lipids between low-birth-weight (LBW) individuals, at increased risk of type 2 diabetes (T2D), and normal-birth-weight (NBW) controls is unknown. The objective of the study was to perform untargeted serum metabolomics and lipidomics analyses in 26 healthy, non-obese early-middle-aged LBW men, i
Adaptive flyway management of superabundant geese is emerging as a strategy to reduce damage to agricultural crops and other ecosystem disservices, while also ensuring sustainable use and conservation objectives. Given the calls for intensified hunting as part of flyway management in Europe, we need to increase the understanding of structural, situational, and psychological factors important for g
The transformation of rainfall into runoff is one of the most important processes in hydrology. In the past few decades, a wide variety of automated or computer-based approaches have been applied to model this process. However, many such approaches have an important limitation in that they treat the rainfall-runoff process as a realization of only a few parameters of linear relationships rather th
A model based on the two‐dimensional stochastic advection‐diffusion equation is developed to forecast properties of individual rain cells in urban areas such as speed and spatial rainfall intensity. Two different modeling approaches are employed, and examples of the results are given. The first approach involves a Gaussian distribution as an analytic solution to the advection‐diffusion equation, w
Background: Anterior resection (AR) is considered the gold standard for curative cancer treatment in the middle and upper rectum. The goal of the sphincter-preserving procedure, such as AR, is vulnerable to anastomotic leak (AL) complications. Defunctioning stoma (DS) became the protective measure against AL. Often a defunctioning loop-ileostomy is used, which is associated with substantial morbid
Recent transport equity literature has proposed a sufficientarian approach to transport planning, according to which all individuals would be entitled to a minimum level of accessibility deemed adequate or sufficient. The implementation of this approach would require the adoption of an accessibility standard as a key performance indicator guiding transport investments, land use planning and servic
The paper presents ethical and legal challenges of holographic communication technologies and suggests a framework to address them. Holographic communications enable the capturing of a user’s 3D depiction via special equipment, and its high-quality transmission to another user located elsewhere, introducing a distinctive data communication experience. Their wrongful use could compromise basic huma
OBJECTIVE: Salt-inducible kinase 2 (SIK2) is abundantly expressed in adipocytes and downregulated in adipose tissue from individuals with obesity or insulin resistance. The main aims of this work were to investigate the involvement of SIKs in the regulation of glucose uptake in primary mature human adipocytes and to identify mechanisms underlying this regulation.METHODS: Primary mature adipocytes
Salt-inducible kinase 2 (SIK2) is highly expressed in white adipocytes, but downregulated in individuals with obesity and insulin resistance. These conditions are often associated with a low-grade inflammation in adipose tissue. We and others have previously shown that SIK2 is downregulated by tumor necrosis factor α (TNFα), however, involvement of other pro-inflammatory cytokines, or the mechanis
Aim: An increasing number of patients survive rectal cancer, resulting in more patients living with the side-effects of the treatment. Exploring quality of life before and after treatment enables follow-up and additional treatment to be adjusted to the patient's needs. The aim of the study was to describe the quality of life during the 24 months following diagnosis and to identify risk factors for
